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Labelling and metabolism of methionine-methyl-11C

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Abstract

Carbon 11 which is a 20.4 minutes half life isotope emitting positrons was used for methionine labelling on the methyl group by action of 11C-methyl-iodide on DL or L homocysteine. With the method described, 20 to 30 mCi of 11C-methyl-methionine (Specific activity 50 mCi/μM) may be obtained within 25 minutes. The 20 Mev proton beam used for 11C production was 10 μA. The metabolism of 11C methionine studied on mice shows a high uptake in pancreas and to a smaller extent in brain. On humans sequential images were obtained at the head level which allowed measurement of the uptake of the radio-labelled compound in the brain so as to study the radioactivity curve in different parts of the organ.

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References

  • Blau, M., Manske, R.F., Bender, M.A.: Clinical experience with 75Se-selenomethionine for pancreas visualisation. J. Nucl. Med. 3, 202 (1962)

    Google Scholar 

  • Herrera, N.E., Gonzalez, R., Schwartz, R., et al.: 75Se methionine as a diagnostic agent in malignant lymphoma. A preliminary communication. J. Nucl. Med. 6, 355–359 (1965)

    Google Scholar 

  • Israelstam, D.M., Sargent, T., Finley, N.N. et al.: Abnormal methionine metabolism in schizophrenia and depressive states. A preliminary report. J. Psychiat. Res. 7, 185–190 (1970)

    Google Scholar 

  • Marazano, C., Maziere, M., Comar, D.: Synthesis of methyl iodide-11C and formaldehide-11C. (To be published)

  • Matthysse, S., Lipinski, J.: Biochemical aspects of schizophrenia. Annual Review of medicine, selected topics in the clinical sciences. 26, 551–565 (1975)

    Google Scholar 

  • Oldendorf, W.H., Sisson, W.B., Silverstein, A.: Brain uptake of selenomethionine-75Se. Arch. Neurol. 24, 524–528 (1971)

    Google Scholar 

  • Oldendorf, W.H.: Brain uptake of radiolabelled amino-acids, amines and hexoses after arterial injection. Amer. J. Physiol. 221, 1629–1639 (1971)

    Google Scholar 

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Authors and Affiliations

  1. Commissariat à l'Energie Atomique-Départment de Biologie, Service Hospitalier Frédéric Joliot, 91406, Orsay, France

    Dominique Comar, Jean-Claude Cartron, Mariannick Maziere & Christian Marazano

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  1. Dominique Comar
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  2. Jean-Claude Cartron
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  3. Mariannick Maziere
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  4. Christian Marazano
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Comar, D., Cartron, JC., Maziere, M. et al. Labelling and metabolism of methionine-methyl-11C. Eur J Nucl Med 1, 11–14 (1976). https://doi.org/10.1007/BF00253260

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  • DOI: https://doi.org/10.1007/BF00253260

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