Abstract
Cytotoxic bioassay-guided fractionation of methanol extract of Angelicae Sinensis Radix led to the isolation of a new dimericZ-ligustilide, named neodiligustilide (1), together with three known compounds,Z-ligustilide (2), 11(S),16(R)-dihydroxy-octadeca-9Z, 17-dien-12, 14-diyn-1-yl acetate (3), and 3(R), 8(S)-falcarindiol (4). Among them, 2 showed the strongest cytotoxicity against L1210 and K562 cell lines with IC50 values of 2.27 ± 0.10 and 4.78 ± 0.18 μM, respectively, while 1 showed moderate cytotoxicity with IC50 values of 5.45 ±0.19 and 9.87 ±0.14 μM. Two polyacetylenes, 3 and 4, showed cytotoxicity only against L1210 cell line with IC50 values of 2.60 ± 0.90 and 2.87 ± 0.49 μM, respectively.
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Chen, Q.C., Lee, J., Jin, W. et al. Cytotoxic constituents from Angelicae Sinensis radix. Arch Pharm Res 30, 565–569 (2007). https://doi.org/10.1007/BF02977650
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DOI: https://doi.org/10.1007/BF02977650