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Unlocking the therapeutic potential of cinchonains: a comprehensive review

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Abstract

Cinchonains are a group of naturally occurring flavonolignans that exhibit a plethora of biological activities. This comprehensive review provides a critical analysis of the research on cinchonains and their related compounds, aiming to describe their various biological activities, including but not limited to, cytotoxicity, antioxidant, anti-inflammatory, antimicrobial, neuroprotective, antidiabetic, and anticancer activities. The occurrence and distribution of cinchonains in plants, their biosynthesis pathways, bioavailability, toxicity, and clinical investigations are also discussed. By synthesizing information from scientific literature, we present an informative and accessible overview of cinchonains' potential as a source of new therapeutics and highlight the importance of continued research on cinchonains and their related compounds to unlock their possible therapeutic merits.

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Authors and Affiliations

  1. AgroBioSciences Program, College for Agriculture and Environmental Science, Mohammed VI Polytechnic University, 43150, Ben Guerir, Morocco

    Nidal Fahsi, Ismail Mahdi, Hassan Annaz, Gabin Thierry M. Bitchagno & Mansour Sobeh

  2. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt

    Mona F. Mahmoud

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  1. Nidal Fahsi
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  2. Ismail Mahdi
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  3. Hassan Annaz
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  6. Mansour Sobeh
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NF, IM, HA and GTMB reviewed the literature and wrote the original draft of the manuscript. MFM revised the manuscript. MS revised the manuscript, designed, and conceived the work.

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Correspondence to Mansour Sobeh.

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Fahsi, N., Mahdi, I., Annaz, H. et al. Unlocking the therapeutic potential of cinchonains: a comprehensive review. Phytochem Rev (2024). https://doi.org/10.1007/s11101-024-09949-5

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