Abstract
The EtOAc soluble fraction from the stem ofSorghum bicolor showed a strong free radical scavenging activity. Five major compounds were isolated from this fraction. They were identified by spectral data as methyl ferulate (1), methylp-hydroxycinnamate (2),p-hydroxybenzal-dehyde (3), tricin (4), and quercetin 3,4’-dimethyl ether (5). Among these compounds,1 exhibited a strong, free radical scavenging activity on 1, 1-diphenyl-2-picrylhydrazyl (DPPH) with an IC50 value of 0.7 μM. We further studied the effects of these isolated compounds on the lipid peroxidation in rat liver microsomes induced by non-enzymatic method. All five compounds showed anti-lipid peroxidation activity (IC50 values of 0.5, 0.4, 0.3 and 0.3 μM, respectively).
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Kwon, Y.S., Kim, C.M. Antioxidant constituents from the stem ofSorghum bicolor . Arch Pharm Res 26, 535–539 (2003). https://doi.org/10.1007/BF02976877
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DOI: https://doi.org/10.1007/BF02976877