Abstract
Twenty seven plant extracts were selected on the basis of ancient literature search for rheumatoid arthritis or similar syndrome. Methanol extract of each plant was prepared and administered orally to rats everyday at a dose of 200 mg/kg/day. Experimental arthritis was induced by subplantar injection of heat-killedMycobacterium butyricum to right hind paw of rats. This treatment provoked swelling of the treated paw in two phases, acute primary swelling and secondary arthritic swelling. An inhibition of secondary swelling was considered to be antiarthritic activity. Several plant methanol extracts such asAkebia quinata (caulis),Ephedra sinica (herba) andSophorae subprostrata (radix) were found to show significant inhibitory activity against secondary swelling at the dose tested. Our results strongly suggested an antiarthritic potential of these plant extracts.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References Cited
Bomalaski, J. S. and Clark, M. A., Phospholipase A2 and arthritis.Arthritis and Rheumatism 36, 190–198 (1993).
Duwiejua, M., Zeitlein, J. J., Waterman, P. G., Chapman, J., Mhango, G. J. and Provan, G. J., Anti-inflammatory activity of resins from some species of the plant family Burseraceae.Planta Med., 59, 12–16 (1993).
Gu, W-Z., Brandwein, R. and Banerjee, S., Inhibition of type II collagen induced arthritis in mice by an immunosuppressive extract ofTripterygium wilfordii Hook f.,J. Rheumatol., 19, 682–688 (1992).
Higuchi, R. and Kawasaki, T., Pericarp saponins ofAkebia quinata Decne. I. Glycosides of hedragenin and oleanolic acid.Chem. Pharm. Bull., 24, 1021–1032 (1976a).
Higuchi, R. and Kawasaki, T., Pericarp saponins ofAkebia quinata Decne. II. Arjunolic and norajunolic acids, and their glycosides.Chem. Pharm. Bull., 24, 1314–1323 (1976b).
Hikino H., Konno, C., Takata, H., Yamada, Y., Yamada, C., Ohizuma, Y., Sugio, K. and Fujimura, H., Anti-inflammatory principles of Aconitum roots.J. Pharmacobiodyn., 3, 514–523 (1980).
Huh, Z., inDong-Eu-Bo-Gam (1613), Namsangdang, Seoul, 1966.
Ikuda, A. and Itokawa, H., 30-Noroleanane saponins from callus tissues ofAkebia quinata.Phytochem, 28, 2663–2665 (1989).
Kim, H. P., Glucocorticoids: Anti-inflammation and immonosuppression.Kor. Biochem. News, 10, 246–251 (1990).
Kubo, M., Matsuda, H., Tanaka, M., Kimura, Y., Okuda, H., Higashino, M., Tani, T., Namba, K. and Arichi, S., Studies ofScutellaria radix. VII. Anti-arthritic and anti-inflammatory actions of methanolic extract and flavonoid components fromScutellaria radix.Chem. Pharm. Bull., 32, 2724–2729 (1984).
Lee, S. J., Shin, E. J., Son, K. H., Chang, H. W., Kang, S. S. and Kim, H. P., Anti-inflammatory activity of the major constituents ofLonicera japonica.Arch. Pharm. Res., 18, 133–135 (1995).
Lee, S. J., Son, K. H., Chang, H. W., Kang, S. S. and Kim, H. P., Anti-inflammatory activity ofLonicera japonica. Phytotherapy Res., in press (1997).
Meade, E. A., Smith, W. L. and DeWitt, L., Differential inhibitor of prostaglandin endoperoxidase synthase (cyclooxygenase) isozymes by aspirin and other nonsteroidal anti-inflammatory drugs.J. Biol. Chem., 268, 6610–6614 (1993).
Newbould, B. B., Chemotherapy of arthritis induced in rats by mycobacterial adjuvant.Br. J. Pharmacol., 21, 127–136 (1963).
Perez, R. M., Perez, S., Zavala, M. A. and Salaza, M., Anti-inflammatory activity of the bark ofHipporatea excela.J. Echnopharmacol., 47, 85–90 (1995).
Sedgwick, A. D. and Willoughby, D. A., Animal models for testing drugs on inflammatory and hypersensitivity reactions, in Maureen Dale and Foreman (eds.)Textbook of immunopharmacology, Black well Sci. Pub., Oxford, 1989, pp. 253–261.
Son, K. H., Jung, K. Y., Chang, H. W., Kim, H. P. and Kang, S. S., Triterpenoid saponins from the aerial parts ofLonicera japonica.Phytochem., 35, 1005–1008 (1994).
Sugita, T., Ueno, M., Furukawa, O., Murakami, T., Takata, I. and Tosa, T., Effect of a novel anti-rheumatic drug, TA-383, on type II collagen-induced arthritis-Suppressive effect of TA-383 on interleukin 6 production.Int. J. Immunopharmacol., 15, 515–519 (1993).
Tang, W. and Eisenbrand, G.,Chinese drugs of plant origin. Springer-Verlag, Berlin, 1992, pp. 931–943.
Waltz, D. T., Dimartino, M. J. and Misher, A., Adjuvant-induced arthritis in rats. II. Drug effects on physiologic, biochemical and immunologic parameters.J. Pharm. Exp. Ther., 178, 223–231 (1971).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kim, S.Y., Son, K.H., Chang, H.W. et al. Inhibitory effects of plant extracts on adjuvant-induced arthritis. Arch. Pharm. Res. 20, 313–317 (1997). https://doi.org/10.1007/BF02976192
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02976192