Abstract
Bioassay-guided fractionation ofCrataegus pinnatifida (Rosaceae) gave two cytotoxic ursane-type triterpenes which were identified as uvaol (1) and ursolic acid (2) by physicochemical and spectroscopic methods. 3-Oxo-ursolic acid (3) was synthesized from ursolic acid (2) by Jones method. The cytotoxic activities of these compounds were tested against murine L1210 and human cancer cell lines (A549, SK-OV-3, SK-MEL-2, XF498, and HCT15)in vitro. Compounds1 and2 showed moderate cytotoxicities against L1210, whereas they showed weak activities against human cancer cell lines. However, compound3 exhibited potent cytotoxic activities both in murine and in human cancer cell lines.
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Min, B.S., Kim, Y.H., Lee, S.M. et al. Cytotoxic triterpenes fromCrataegus pinnatifida . Arch Pharm Res 23, 155–158 (2000). https://doi.org/10.1007/BF02975505
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DOI: https://doi.org/10.1007/BF02975505