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Hypertensive and Toxicological Study of Citric Acid and Other Constituents fromTagetes patula Roots

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Abstract

Study of the effects of the methanolic extract ofTagetes patula roots on blood pressure led to the isolation of well known citric (1) and malic acid (7) as hypotensive, and pyridine hydrochloride (4) as hypertensive constituents of the plant along with a new constituent, 2-hydroxy, 5-hydroxymethyl furan (9). Citric acid and malic acid caused 71% and 43% fall in Mean Arterial Blood Pressure (MABP) of rats at the doses of 15 mg/kg and 30mg/kg respectively while pyridine hydrochloride produced 34% rise in the MABP of rats at the dose of 30mg/kg. LD50 and LD100 of citric acid in mice have been determined as 545 mg/kg and 1000 mg/kg, respectively.

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Authors and Affiliations

  1. Dr. HMI Institute of Pharmacology and Herbal Sciences, Hamdard University, 74600, Karachi, Pakistan

    Rubeena Saleem, Mohammad Ahmad, Aneela Naz, Humaira Siddiqui, Syed Iqbal Ahmad & Shaheen Faizi

  2. HEJ Research Institute of Chemistry, University of Karachi, 75270, Karachi, Pakistan

    Aneela Naz, Humaira Siddiqui & Shaheen Faizi

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  1. Rubeena Saleem
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  2. Mohammad Ahmad
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  3. Aneela Naz
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  4. Humaira Siddiqui
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  5. Syed Iqbal Ahmad
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  6. Shaheen Faizi
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Correspondence to Rubeena Saleem.

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Saleem, R., Ahmad, M., Naz, A. et al. Hypertensive and Toxicological Study of Citric Acid and Other Constituents fromTagetes patula Roots. Arch Pharm Res 27, 1037–1042 (2004). https://doi.org/10.1007/BF02975428

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  • DOI: https://doi.org/10.1007/BF02975428

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