Abstract
An oriental herbal combination (BDX-1) was isolated fromAchyranthes bidentata andAtractylodes japonica. We previously tested the clinical effectiveness of BDX-1 in rheumatoid arthritis (RA) patients and found that it has a beneficial therapeutic effect. Here, we provide experimental evidence for the effectiveness of BDX-1 on RA in murine models. The oral administration of BDX-1 was found to markedly inhibit collagen-induced arthritis, adjuvant-induced arthritis, and zymosan-induced inflammation. It also inhibited carrageenan-induced acute edema and acetic acid-induced writhing response. In addition, the biological activity of BDX-1 was found to be strongly increased by fermentation. Our results suggest that BDX-1 could be useful for the treatment of rheumatoid arthritis.
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Han, SB., Lee, C.W., Yoon, L.D. et al. Prevention of arthritic inflammation using an oriental herbal combination BDX-1 isolated fromAchyranthes bidentata andAtractylodes japonica . Arch Pharm Res 28, 902–908 (2005). https://doi.org/10.1007/BF02973875
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DOI: https://doi.org/10.1007/BF02973875