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Synthesis of C4-modified acanthoic acid analogs and their biological evaluation as nitric oxide inhibitors

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Abstract

Synthesis and biological evaluation of a series of C4-modified acanthoic acid analogs are reported. Among them, the analog 7 and 10 exhibit potent cellular inhibitory activity in NO inhibition assay.

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Authors and Affiliations

  1. College of Pharmacy, Seoul National University, 151-742, Seoul, Korea

    Kwang-Ok Lee, Kyung-Hoon Min & Young-Ger Suh

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  1. Kwang-Ok Lee
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  2. Kyung-Hoon Min
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  3. Young-Ger Suh
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Correspondence to Young-Ger Suh.

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Lee, KO., Min, KH. & Suh, YG. Synthesis of C4-modified acanthoic acid analogs and their biological evaluation as nitric oxide inhibitors. Arch Pharm Res 28, 648–651 (2005). https://doi.org/10.1007/BF02969352

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  • DOI: https://doi.org/10.1007/BF02969352

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