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Technetium 94m-labeled methoxyisobutyl isonitrile: Dosimetry and resting cardiac imaging with positron emission tomography

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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

Development of a positronemitting form of technetium has allowed the imaging of technetium radiopharmaceuticals with positron emission tomography (PET). We used94mTc to compare the distribution of the myocardial perfusion agent sestamibi at rest with the conventional PET perfusion tracer13N-labeled ammonia (13N-ammonia).

Methods and Results

Dosimetry calculations were performed with the known wholebody distribution of99mTc-labeled sestamibi. Dynamic PET imaging of13N-ammonia and94mTc-labeled sestamibi (94mTc-sestamibi) for 32 minutes was performed in eight patients with previous myocardial infarction. Initial myocardial and extramyocardial distribution of94mTc-sestamibi was compared with that of13N-ammonia by qualitative and quantitative analysis. Quantitative comparison of the two tracers was performed with region-of-interest analysis and circumferential profiles. Qualitatively, the cardiac distribution of the tracers was similar in normal and infarcted myocardium. A decrease in the definition of the epicardial and endocardial borders of the heart was seen with94mTc-sestamibi, presumably because of the lower dose of radionuclide injected. Quantitatively, there was no difference in infarct size, defined prospectively as tracer activity less than 20% of maximum activity for the section, between the two tracers. Circumferential profile analysis with 12-degree radial sections similarly demonstrated no difference in regional cardiac distribution of the tracers.

Conclusions

These results revealed no significant difference in myocardial uptake compared with13N-ammonia suggesting that the myocardial uptake of sestamibi correlates with that of myocardial perfusion.

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Authors and Affiliations

  1. William S. Middleton Veterans Administration Hospital, University of Wisconsin Positron Emission Tomography Center, USA

    Charles K. Stone, Bradley T. Christian, Robert J. Nickles & Scott B. Perlman

  2. Departments of Medicine (Cardiology Section), Radiology (Nuclear Medicine Section), and Medical Physics, University of Wisconsin-Madison Medical School, Madison, Wis.

    Charles K. Stone, Bradley T. Christian, Robert J. Nickles & Scott B. Perlman

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  1. Charles K. Stone
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  2. Bradley T. Christian
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  3. Robert J. Nickles
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  4. Scott B. Perlman
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Additional information

Supported by National Institutes of Health grant R29 HL47003 (FIRST Award). Presented in part at the Forty-second Annual Scientific Sessions of the American College of Cardiology, March 1993.

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Stone, C.K., Christian, B.T., Nickles, R.J. et al. Technetium 94m-labeled methoxyisobutyl isonitrile: Dosimetry and resting cardiac imaging with positron emission tomography. J. Nucl. Cardiol. 1, 425–433 (1994). https://doi.org/10.1007/BF02961596

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  • DOI: https://doi.org/10.1007/BF02961596

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