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Comparison between total and ultrafiltrable serum zinc as test to diagnose zinc deficiency in infants and children

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Abstract

Total Serum Zinc (TSZn) and albumin were determined, and low molecular weight serum Zn measured by radiochemical Ultra-Filtration (UFSZn) in healthy Dutch infants and children, and in samples obtained from those with diseases that are expected to alter TSZn.

Our control TSZn values, 10.2±3.5 μmol/L, were low compared to those reported in the literature. Variation in serum albumin could not explain this: No correlation of TSZn with serum albumin was found (p>0.5). Likely explanations are the nonfasting state and the stress owing to hospital surroundings at the time of sampling. A range of other influences not registered may be active and are discussed. No significant age-dependence was found (p<0.8). Boys over 9 yr of age showed higher TSZn compared with girls of the same age (p<0.08). In a separate experiment a 17% decrease in TSZn was demonstrated by food intake (eggs). These results support the opinion that TSZn is of little value to measure Zn status. There was no discrimination in TSZn between healthy subjects and patients.

Our UFSZn values, 0.28±0.13 μmol/L in the controls as well as in the patients, were correlated with TSZn and therefore not a suitable alternative for the measurement of TSZn as parameter to determine the Zn status. The UFSZn was not correlated with serum albumin (p>0.7). UFSZn values were higher in infants (p<0.01), no sex dependence was found. We conclude that TSZn as well as UFSZn are of limited clinical relevance.

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References

  1. B. L. Vallee,J. Inher. Metab. Dis. 6(suppl.),1, 31 (1983).

    Article  PubMed  CAS  Google Scholar 

  2. A. Klug and D. Rhodes,Trends Biochem. Sci. 12, 464 (1987).

    Article  CAS  Google Scholar 

  3. M. S. Lee,Science 245, 635 (1989).

    Article  PubMed  CAS  Google Scholar 

  4. R. Berfenstam,Acta Paediatr. 41(suppl.), 87 (1952).

    Article  Google Scholar 

  5. H. H. Hellwege,Monatschr. Kinderheilk. 119, 37 (1971).

    CAS  Google Scholar 

  6. K. Kasperek, L. E. Feinendegen, I. Lombeck, and H. J. Bremer,Eur. J. Pediatr. 126, 199 (1977).

    Article  PubMed  CAS  Google Scholar 

  7. R. Laitinen, E. Vuori, S. Dahlström, and H. V. Äkerblom,Ped. Res. 25, 323 (1989).

    Article  CAS  Google Scholar 

  8. R. Laitinen,Biol. Trace Elem. Res. 25, 71 (1990).

    Article  PubMed  CAS  Google Scholar 

  9. S. M. Pilch, and R. Senti (eds.),Assessment of the zinc nutritional status of the U.S. population based on data collected in the second national health and nutrition examination survey, 1976–1980. Life Sciences Research Office, FASEB, Bethesda MD (1984).

    Google Scholar 

  10. T. Hongo, T. Suzuki, T. Ohba, K. Karita, Y. Dejima, J. Yoshinaga, M. Togo, H. Ishida, H. Suzuki, and E. Hisatsune,J. Nutr. Sci. Vitaminol. 38, 177 (1992).

    PubMed  CAS  Google Scholar 

  11. H. Fauré, A. Favier, M. Tripier, and J. Arnaud,Biol. Trace Elem. Res. 24, 25 (1990).

    Article  PubMed  Google Scholar 

  12. J. C. Van Wieringen, M. J. Roede, and J. M. Wit,Tijdschr. Kindergeneesk. 53, 147 (1985).

    Google Scholar 

  13. K. E. C. De Haan, C. J. De Groot, C. J. A. Van den Hamer, and H. Boxma,Clin. Chim. Acta 170, 111 (1987).

    Article  PubMed  Google Scholar 

  14. R. C. Whitehouse, A. S. Prasad, and Z. T. Cossack,Clin. Chem. 29, 1974 (1983).

    PubMed  CAS  Google Scholar 

  15. E. L. Giroux, D. Durieux, and P. Schechter,Bioinorg. Chem. 5, 211 (1976).

    Article  PubMed  CAS  Google Scholar 

  16. M. Persigehl, A. Höck, K. Kasperek, E. Land, and L. E. Feinendegen,Zeitschr. Klin. Chem. Klin. Biochem. 12, 171 (1974).

    CAS  Google Scholar 

  17. D. McMaster, E. McCrum, C. C. Patterson, M. McKerr, D. O'Reilly, A. E. Evans, and A. H. G. Love,Am. J. Clin. Nutr. 56, 440 (1992).

    PubMed  CAS  Google Scholar 

  18. C. E. Casey, P. A. Walravens, and K. M. Hambidge,Am. J. Clin. Nutr. 34, 1443 (1981).

    PubMed  CAS  Google Scholar 

  19. A. S. Prasad,J. Am. Coll. Nutr. 4, 591 (1985).

    PubMed  CAS  Google Scholar 

  20. B. E. Walker, I. Bone, B. H. Mascie-Taylor, and J. Kelleher,Int. J. Vit. Nutr. Res. 49, 413 (1979).

    CAS  Google Scholar 

  21. M. E. Markowitz, J. F. Rosen, and M. Mizruchi,Am. J. Clin. Nutr. 41, 689 (1985).

    PubMed  CAS  Google Scholar 

  22. H. Ohno, K. Yamashita, R. Doi, K. Yamamura, T. Kondo, and N. Taniguchi,J. Appl. Physiol. 58(5) 1453 (1985).

    PubMed  CAS  Google Scholar 

  23. J. C. Wallwork,Biol. Trace Elem. Res. 12, 335 (1987).

    Article  CAS  Google Scholar 

  24. M. T. Baer, and J. C. King,Am. J. Clin. Nutr. 39, 556 (1984).

    PubMed  CAS  Google Scholar 

  25. J. P. Van Wouwe, H. H. Van Gelderen, and J. H. Bos,Eur. J. Pediatr. 146, 293 (1987).

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics, Drechtsteden Hospital “Jacobus”, Langeweg 336, 3331 LZ, Zwijndrecht, the Netherlands

    Jacobus P. Van Wouwe & Ilse Waser

  2. Department of Radiochemistry, Interfaculty Reactor Institute, Delft University of Technology, Delft, the Netherlands

    Jacobus P. Van Wouwe

Authors
  1. Jacobus P. Van Wouwe
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  2. Ilse Waser
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Van Wouwe, J.P., Waser, I. Comparison between total and ultrafiltrable serum zinc as test to diagnose zinc deficiency in infants and children. Biol Trace Elem Res 40, 203–211 (1994). https://doi.org/10.1007/BF02950793

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  • DOI: https://doi.org/10.1007/BF02950793

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