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Cellular and molecular aspects of myelin protein gene expression

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Abstract

The cellular and molecular aspects of myelin protein metabolism have recently been among the most intensively studied in neurobiology. Myelination is a developmentally regulated processinvolving the coordination of expression of genes encoding both myelin proteins and the enzymes involved in myelin lipid metabolism. In the central nervous system, the oligodendrocyte plasma membrane elaborates prodigious amounts of myelin over a relatively short developmental period. During development, myelin undergoes characteristic biochemical changes, presumably correlated with the morphological changes during its maturation from loosely-whorled bilayers to the thick multilamellar structure typical of the adult membrane.

Genes encoding four myelin proteins have been isolated, and each of these specifies families of polypeptide isoforms synthesized from mRNAs derived through alternative splicing of the primary gene transcripts. In most cases, the production of the alternatively spliced transcripts is developmentally regulated, leading to the observed protein compositional changes in myelin. The chromosomal localizations of several of the myelin protein genes have been mapped in mice and humans, and abnormalities in two separate genes appear to be the genetic defects in the murine dysmyelinating mutants,shiverer andjimpy. Insertion of a normal myelin basic protein gene into theshiverer genome appears to correct many of the clinical and cell biological abnormalities associated with the defect. Most of the dysmyelinating mutants, including those in which the genetic defect is established, appear to exhibit pleiotropy with respect to the expression of other myelin genes.

Post-translational events also appear to be important in myelin assembly and metabolism. The major myelin proteins are synthesized at different subcellular locations and follow different routes of assembly into the membrane. Prevention of certain post-translational modifications of some myelin proteins can result in the disruption of myelin structure, reminiscent of naturally occurring myelin disorders. Studies on the expression of myelin genes in tissue culture have shown the importance of epigenetic factors (e. g., hormones, growth factors, and cell-cell interactions) in modulating myelin protein gene expression. Thus, myelinogenesis has proven to be very useful system in which to examine cellular and molecular mechanisms regulating the activity of a nervous system-specific process.

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Abbreviations

bp:

Base pair(s)

cDNA:

Complementary DNA

CNP:

2′,3′-cyclic nucleotide 3′-phosphodiesterase

CNS:

Central nervous system

DM20:

25 kdalton myelin proteolipid protein

GC:

Galactosyl Ceramide

GM4 :

Sialosylgalactosylceramide

MAG:

Myelin associated glycoprotein

MBP:

Myelin basic protein

nt:

Nucleotide(s)

PAGE:

Polyacrylamide gel electrophoresis

PLP:

(30 kdalton myelin) proteolipid protein

PNS:

Peripheral nervous system

RIA:

Radioimmunoassay

SCD:

Subacute combined degeneration

SDS:

Sodium dodecyl sulfate

T3 :

Triiodothyronine

References

  • Adams D. H. and Osborne J. (1973) A developmental study of the relationship between the protein components of rat CNS myelin.Neurobiol. 3, 91–112.

    CAS  Google Scholar 

  • Agamanolis D. P., Victor M., Harris J. W., Hines J. D., Chester E. M., and Kark J. A. (1978) An ultrastructural study of subacute combined degeneration of the spinal cord in vitamin B12-deficient rhesus monkeys.Neuropath. Exp. Neurol. 37, 273–299.

    CAS  Google Scholar 

  • Agrawal H. C., Agrawal D., and Jenkins R. P. (1986) Immunochemical evidence for phosphorylation of a new 23 K basic protein in rat brain myelin.Neurochem. Res. 11, 375–382.

    PubMed  CAS  Google Scholar 

  • Agrawal H. C., Burton R. M., Fishman M. A., Mitchell R. F., and Prensky A. L. (1972) Partial characterization of a new myelin protein component.J. Neurochem. 19, 2083–2089.

    PubMed  CAS  Google Scholar 

  • Agrawal H. C. and Hartman B. K. (1980)Proteins of the Nervous System, second ed., Bradshaw, R. A. and Schneider, D. M., eds., Raven Press, NY, pp. 145–169.

    Google Scholar 

  • Agrawal H. C., O'Connell K., Randle C. L., and Agrawal D. (1982a) Phosphorylation in vivo of four basic proteins of rat brain myelin.Biochem. J. 201, 39–47.

    PubMed  CAS  Google Scholar 

  • Agrawal H. C., Randle C. L., and Agrawal D. (1981) In vivo phosphorylation of two myelin basic proteins of developing rabbit brain.J. Biol. Chem. 256, 12243–12246.

    PubMed  CAS  Google Scholar 

  • Agrawal H. C., Randle C. L., and Agrawal D. (1982b) In vivo acylation of rat brain myelin proteolipid protein.J. Biol. Chem. 257, 4588–4592.

    PubMed  CAS  Google Scholar 

  • Almazan G., Honegger P., and Matthieu J.-M. (1985) Triiodothyronine stimulation of oligodendroglial differentiation and myelination. A developmental study.Dev. Neurosci. 7, 45–54.

    PubMed  CAS  Google Scholar 

  • Amur S. G., Shanker G., Cochran J. M., Ved H. S., and Pieringer R. A. (1986) Correlation between inhibition of myelin basic protein (arginine) methyltransferase by sinefungin and lack of compact myelin formation in cultures of cerebral cells from embryonic mice.J. Neurosci. Res. 16, 367–376.

    PubMed  CAS  Google Scholar 

  • Amur S. G., Shanker G. and Pieringer R. A. (1984) Regulation of myelin basic protein (arginine) methyltransferases by thyroid hormone in myelinogenic cultures of cells dissociated from embryonic mouse brain.J. Neurochem. 43, 494–498.

    PubMed  CAS  Google Scholar 

  • Arquint M., Roder J., Chia L.-S., Down J., Wilkinson D., Bayley H., Braun P., and Dunn R. (1987) Molecular cloning and primary structure of myelinassociated glycoprotein.Proc. Natl. Acad. Sci. USA 84, 600–604.

    PubMed  CAS  Google Scholar 

  • Balazs R., Brooksbank B. W. L., Davison A. N., Eayrs J. T., and Wilson D. A. (1969) The effect of neonatal thyroidectomy on myelination in the rat brain.Brain Res. 15, 219–232.

    PubMed  CAS  Google Scholar 

  • Balazs R., Brooksbank B. W. L., Patel A. J., Johnson A. L., and Wilson D. A. (1971) Incorporation of [35S] sulfate into brain constituents during development and the effect of thyroid hormone in myelination.Brain Res. 30, 273–293.

    PubMed  CAS  Google Scholar 

  • Baldwin G. S. and Carnegie P. R. (1971) Specific enzymic methylation of an arginine in the experimental allergic encephalomyelitis protein from human myelin.Science 171, 579–581.

    PubMed  CAS  Google Scholar 

  • Banik N. L., Davison A. N., Ramsey R. B., and Scott T. (1974) Protein composition in developing human brain myelin.Dev. Psychobiol. 7, 539–549.

    PubMed  CAS  Google Scholar 

  • Banik N. L. and Smith M. E. (1977) Protein determinants of myelination in different regions of developing rat central nervous system.Biochem. J. 162, 247–255.

    PubMed  CAS  Google Scholar 

  • Bansal G., Martenson R. E., Leveille P., and Campagnoni A. T. (1987) Characterization of a novel monoclonal anti-myelin basic protein antibody: use in immunoblotting and immunohistochemical studies.J. Neuroimmunol. 15, 279–294.

    PubMed  CAS  Google Scholar 

  • Bansal R. and Pfeiffer S. E. (1985) Developmental expression of 2′,3′-cyclic nucleotide 3′-phospho-hydrolase in dissociated fetal rat brain cultures and rat brain.J. Neurosci. Res. 14, 21–34.

    PubMed  CAS  Google Scholar 

  • Barbarese E., Braun P. E., and Carson J. H. (1977) Identification of prelarge and presmall basic proteins in mouse myelin and their structural relationship to large and small basic proteins.Proc. Natl. Acad. Sci. USA 74, 3360–3364.

    PubMed  CAS  Google Scholar 

  • Barbarese E., Carson J. H., and Braun P. E. (1978) Accumulation of the four myelin basic proteins in mouse brain during development.J. Neurochem. 31, 779–782.

    PubMed  CAS  Google Scholar 

  • Barbarese E., Nielson M. L., and Carson J. H. (1983) The effect of theshiverer mutation on myelin basic protein expression in homozygous and heterozygous mouse brain.J. Neurochem. 40, 1680–1686.

    PubMed  CAS  Google Scholar 

  • Barbarese E. and Pfeiffer S. E. (1981) Developmental regulation of myelin basic protein in dispersed cultures.Proc. Natl. Acad. Sci. USA 78, 1953–1957.

    PubMed  CAS  Google Scholar 

  • Bartlett W. P., Knapp P. E., and Skoff R. P. (1987) Medium conditioned by normal brain cells rescuesjimpy oligodendrocytes in vitro.J. Neurochem 48, S43.

    Google Scholar 

  • Bartlett W. P. and Skoff R. P. (1986) Expression of thejimpy gene in the spinal cords of heterozygous female mice. I. An early myelin deficit followed by compensation.J. Neurosci. 6, 2801–2812.

    Google Scholar 

  • Baumann N. (1980)Neurological Mutations Affecting Myelination. Inserm Symposium 14, Elsevier, Amsterdam, 565 pp.

    Google Scholar 

  • Benjamins J. A., Gray M., and Morell P. (1976) Metabolic relationships between myelin subfractions: entry of proteins.J. Neurochem. 27, 571–575.

    PubMed  CAS  Google Scholar 

  • Benjamin J. A., Jones, M., and Morell, P. (1975) Appearance of newly synthesized protein in myelin of young rats.J. Neurochem. 24, 1117–1122.

    Google Scholar 

  • Benjamins J. A. and Morell P. (1978) Proteins of myelin and their metabolism.Neurochem. Res. 3, 137–174.

    PubMed  CAS  Google Scholar 

  • Benjamins J. A., Skoff R. P., and Beyer K. (1984) Biochemical expression of mosaicism in female mice heterozygous for thejimpy gene.J. Neurochem. 42, 487–492.

    PubMed  CAS  Google Scholar 

  • Benjamins J. A., Studzinski D. M., and Skoff R. P. (1986) Biochemical correlates of myelination in brain and spinal cord of mice heterozygous for thejimpy gene.J. Neurochem. 47, 1857–1863.

    PubMed  CAS  Google Scholar 

  • Berlet H. H. and Volk B. (1980) Studies of human myelin proteins during old age.Mech. Aging Dis. 14, 211–222.

    CAS  Google Scholar 

  • Bernier L., Alvarez F., Norgard E. M., Raible D. W., Mentaberry A., Schembri J. G., Sabatini D. D., and Colman D. R. (1987) Molecular cloning of a 2′, 3′-cyclic nucleotide 3′-phosphodiesterase: mRNAs with different 5′ ends encode the same set of proteins in nervous and lymphoid tissues.J. Neurosci. (in press).

  • Bhat N. R., Sarlieve L. L., Subba Rao G., Pieringer R. A. (1979) Investigations on myelination in vitro: Regulation by thyroid hormone in cultures of dissociated brain cells from embryonic mice.J. Biol. Chem. 254, 9342–9344.

    PubMed  CAS  Google Scholar 

  • Bhat N. R., Shanker G., and Pieringer R. A. (1981a) Investigations on myelination in vitro: regulation of 2′, 3′-cyclic nucleotide 3′ phosphohydrolase by thyroid hormone in cultures of dissociated brain cells from embryonic mice.J. Neurochem. 37, 695–701.

    PubMed  CAS  Google Scholar 

  • Bhat N. R., Subba Rao G., and Pieringer R. A. (1981b) Investigations on myelination in vitro: Regulation of sulfolipid synthesis by thyroid hormone in cultures of dissociated brain cells from embryonic mice.J. Biol. Chem. 256, 1167–1171.

    PubMed  CAS  Google Scholar 

  • Bhat S., Barbarese E., and Pfeiffer S. E. (1981c) Requirement for non-oligodendrocyte cell signals for optimal myelinogenic gene expression in long-term cultures of purified rat oligodendrocytes.Proc. Natl. Acad. Sci. USA 78, 1283–1287.

    PubMed  CAS  Google Scholar 

  • Bhat S. and Pfeiffer S. E. (1985) Subcellular distribution and developmental expression of cholesterol ester hydrolases in fetal rat brain cultures.J. Neurochem. 45, 1356–1362.

    PubMed  CAS  Google Scholar 

  • Bhat S. and Pfeiffer S. (1986) Stimulation of oligodendrocytes by extracts from astrocyte-enriched cultures.J. Neurosci. Res. 15, 19–27.

    PubMed  CAS  Google Scholar 

  • Billings-Gagliardi S. and Adcock L. (1981) Hypomyelinated mutant mice IV: Peripheral myelin injp msd.Brain Res. 225, 309–317.

    PubMed  CAS  Google Scholar 

  • Billings-Gagliardi S., Adcock L. H., Lamperti E. D., Schwing-Stanhope G., and Wolf M. K. (1983) Myelination ofjp, jp msd,andqk axons by normal glia in vitro: Ultrastructural and autoradiographic evidence.Brain Res. 268, 255–266.

    PubMed  CAS  Google Scholar 

  • Billings-Gagliardi S., Adcock L. H., Schwing G. B., and Wolf M. K. (1980) Hypomyelinated mutant mice II. Myelination in vitro.Brain Res. 200, 135–150.

    PubMed  CAS  Google Scholar 

  • Billings-Gagliardi S., Wolf M. K., Kirschner D. A., and Kerner A. L. (1986)Shiverer-jimpy double mutant mice II. Morphological evidence supports reciprocal intergenic suppression.Brain Res. 374, 54–62.

    PubMed  CAS  Google Scholar 

  • Bizzozero O. A., McGarry J. F., and Lees M. B. (1986) Acylation of rat brain myelin proteolipid protein with different fatty acids.J. Neurochem. 47, 772–778.

    PubMed  CAS  Google Scholar 

  • Bizzozero O. A., McGarry J. F., and Lees M. (1987a) Acylation of isolated myelin proteolipid protein.J. Neurochem. 48, S33.

    Google Scholar 

  • Bizzozero O. A., McGarry J. F., and Lees M. B. (1987b) Acylation of endogenous myelin proteolipid protein with different acyl-CoAs.J. Biol. Chem. 262, 2138–2145.

    PubMed  CAS  Google Scholar 

  • Bizzozero O. A., Soto E. F., and Pasquini J. M. (1983) Myelin proteolipid protein.Neurochem. Int. 5, 729–736.

    CAS  Google Scholar 

  • Bizzozero O. A., Soto E. F., and Pasquini J. M. (1984) Simultaneous entry of palmitic acid into proteolipid protein in different myelin subfractions of rat brain.Neurochem. Int. 6, 659–664.

    CAS  Google Scholar 

  • Bologa L. (1985) Oligodendrocytes, key cells in myelination and target in demyelinating diseases.J. Neurosci. Res. 14, 1–20.

    PubMed  CAS  Google Scholar 

  • Bologa L., Aizenman Y., Chiapelli F., and deVellis J. (1986) Regulation of myelin basic protein in oligodendrocytes by a soluble neuronal factor.J. Neurosci. Res. 15, 521–528.

    PubMed  CAS  Google Scholar 

  • Bourre J. M., Jacque C., Delassale A., Nguyen-Largros J., Dumont O., Lachapelle F., Raoul M., Alvarez C., and Baumann N. (1980) Density profile and basic protein measurements in the myelin range of particulate material from normal developing mouse brain and from neurological mutants.J. Neurochem. 35, 458–464.

    PubMed  CAS  Google Scholar 

  • Braun P. E. and Radin N. S. (1969) Interactions of lipids with a membrane structural protein from myelin.Biochemistry 8, 4310–4318.

    PubMed  CAS  Google Scholar 

  • Breitbart R. E., Andreadis A., and Nadal-Ginard B. (1987) Alternative splicing: a ubiquitous mechanism for the generation of multiple protein isoforms from single genes.Ann. Rev. Biochem. 56, 467–495.

    PubMed  CAS  Google Scholar 

  • Brostoff S. and Eylar E. H. (1971) Localization of methylated arginine in the A1 protein from myelin.Proc. Nat. Acad. Sci. USA 68, 765–769.

    PubMed  CAS  Google Scholar 

  • Brostoff S., Greenfield S., and Hogan E. L. (1977) The differentiation of synthesis from incorporation of basic protein inquaking mutant mouse myelin.Brain Res. 120, 517–520.

    PubMed  CAS  Google Scholar 

  • Cammer W. (1982) Partial deficiencies in the myelin proteins of developing mice heterozygous for theshiverer mutation.Dev. Genet. 3, 155–163.

    CAS  Google Scholar 

  • Cammer W., Sacchi R., Kahn S., and Sapirstein V. (1985) Oligodendroglial structures and distribution shown by carbonic anhydrase immunostaining in the spinal cords of developing normal andshiverer mice.J. Neurosci. Res. 14, 303–316.

    PubMed  CAS  Google Scholar 

  • Cammer W. and Zimmerman Jr., T. R. (1983) Distribution of myelin-associated enzymes and myelin proteins into membrane fractions from the brains of adultshiverer and control (+/+) mice.Brain Res. 265, 73–80.

    PubMed  CAS  Google Scholar 

  • Campagnoni A. T. (1985) Molecular biology of myelination: gene expression of myelin basic protein.Gene Expression in Brain, (Zomzely-Neurath C. and Walker W. A., eds.), John Wiley, pp. 205–233.

  • Campagnoni A. T., Campagnoni C. W., Bourre J.-M., Jacque C., and Baumann N. (1984) Cell-free synthesis of myelin basic proteins in normal and dysmyelinating mutant mice.J. Neurochem. 42, 733–739.

    PubMed  CAS  Google Scholar 

  • Campagnoni A. T., Campagnoni C. W., Dutton G. R., and Cohen J. (1976) A regional study of developing rat brain: the accumulation and distribution of proteolipid proteins.J. Neurobiol. 7, 313–324.

    PubMed  CAS  Google Scholar 

  • Campagnoni A. T., Campagnoni C. W., Huang A. L., and Sampugna J. (1972) Developmental changes in the basic proteins of normal andjimpy mouse brain.Biochem. Biophys. Res. Commun. 46, 700–707.

    PubMed  CAS  Google Scholar 

  • Campagnoni A. T., Carey G. D., and Yu Y.-T. (1960) In vitro synthesis of the myelin basic proteins: subcellular site of synthesis.J. Neurochem. 34, 677–686.

    Google Scholar 

  • Campagnoni A. T. and Hunkeler M. J. (1980) Synthesis of the myelin proteolipid protein in the developing mouse brain.J. Neurobiol. 11, 355–364.

    PubMed  CAS  Google Scholar 

  • Campagnoni A. T., Hunkeler M. J., and Moskaitis J. E. (1987a) Translational regulation of myelin basic protein synthesis.J. Neurosci. Res. 17, 102–110.

    PubMed  CAS  Google Scholar 

  • Campagnoni A. T., Sorg B. A., Roth H. J., Kronquist K., Newman S. L., Kitamura K., Campagnoni C. W., and Crandall B. F. (1987b) Expression of myelin protein genes in the developing brain.J. Physiol. (Paris) (in press).

  • Campagnoni C. W., Carey G. D., and Campagnoni A. T. (1978) Synthesis of myelin proteins in the developing mouse brain.Arch. Biochem. Biophys. 190, 118–125.

    PubMed  CAS  Google Scholar 

  • Carnegie P. R. (1971) Properties, structure, and possible neuroreceptor role of the encephalitogenic protein of human brain.Nature 229, 25–28.

    PubMed  CAS  Google Scholar 

  • Carnegie P. R., Dunkley P. P., Kemp B. E., and Murray A. W. (1974) Phosphorylation of selected serine and threonine residues in myelin basic protein by endogenous and exogenous protein kinases.Nature 249, 147–150.

    PubMed  CAS  Google Scholar 

  • Carnow T. B., Carson J. H., Brostoff S. W., and Hogan E. L. (1984) Myelin basic protein gene expression inquaking, jimpy, andmyelin synthesis-deficient mice.Dev. Biol. 106, 38–44.

    PubMed  CAS  Google Scholar 

  • Carson J. H., Nielson M. L., and Barbarese E. (1983) Developmental regulation of myelin basic protein expression in mouse brain.Dev. Biol. 96, 485–492.

    PubMed  CAS  Google Scholar 

  • Chan D. S. and Lees M. B. (1974) Gel electrophoresis studies of bovine brain white matter proteolipid and myelin proteins.Biochemistry 13, 2704–2712.

    PubMed  CAS  Google Scholar 

  • Chanderkar L. P., Paik W. K., and Kim S. (1986) Studies on myelin basic protein-methylation during mouse brain development.Biochem. J. 240, 471–479.

    PubMed  CAS  Google Scholar 

  • Chernoff G. (1981)Shiverer: an autosomal recessive mutant mouse with myelin deficiency.J. Hered. 72, 128.

    PubMed  CAS  Google Scholar 

  • Colman D. R., Kreibich G., Frey A. B., and Sabatini D. D. (1982) Synthesis and incorporation of myelin polypeptides into CNS myelin.J. Cell Biol. 95, 598–608.

    PubMed  CAS  Google Scholar 

  • Crang A. J. and Jacobson W. (1982) The relationship of myelin basic protein (arginine) methyltransferase to myelination in mouse spinal cord.J. Neurochem. 39, 244–247.

    PubMed  CAS  Google Scholar 

  • Csiza C. K. and de Lahunta A. (1979) Myelin deficiency (md): a neurological mutant in the Wistar rat.Am. J. Pathol. 95, 215–219.

    PubMed  CAS  Google Scholar 

  • Dautigny A., Alliel P. M., d'Auriol L., Pham Dinh D., Nussbaum J.-L., Galibert F., and Jolles P. (1985) Molecular cloning and nucleotide sequence of a cDNA clone coding for rat brain myelin proteolipid.FEBS Lett. 188, 33–36.

    PubMed  CAS  Google Scholar 

  • Dautigny A., Alliel P. M., Nussbaum J. L., and Jolles P. (1983) Cell-free synthesis of rat brain myelin proteolipids and their identification by immunoprecipitation.Biochem. Biophys. Res. Comm. 110, 432–437.

    PubMed  CAS  Google Scholar 

  • Dautigny A., Mattei M.-G., Morello D., Alliel P. M., Pham-Dinh D., Amar L., Arnaud D., Simon D., Mattei J.-F., Guenet J.-L., Jolles P., and Avner P. (1986) The structural gene coding for myelin associated proteolipid protein is mutated injimpy mice.Nature 321, 867–869.

    PubMed  CAS  Google Scholar 

  • deFerra F., Engh H., Hudson L., Kamholz J., Puckett C., Molineaux S., and Lazzarini R. A. (1985) Alternative splicing accounts for the four forms of myelin basic protein.Cell 43, 721–727.

    CAS  Google Scholar 

  • Deibler G. E., Krutzsch C. H., and Kies M. W. (1986) A new form of myelin basic protein found in human brain.J. Neurochem. 47, 1219–1225.

    PubMed  CAS  Google Scholar 

  • Delassale A., Zalc B., Lachapelle R., Raoul M., Collier P., and Jacque C. (1981) Regional distribution of myelin basic protein in the CNSquaking, jimpy, and normal mice during development and aging.J. Neurosci. Res. 6, 303–313.

    Google Scholar 

  • DesJardins K. C. and Morell P. (1983) Phosphate group modifying myelin basic proteins are metabolically labile; methyl groups are stable.J. Cell Biol. 97, 438–446.

    PubMed  CAS  Google Scholar 

  • Diehl H.-J., Schaich M., Budzinski R.-M., and Stoffel W. (1986) Individual exons encode the integral membrane domains of human myelin proteolipid protein.Proc. Natl. Acad. Sci. USA 83, 9807–9811.

    PubMed  CAS  Google Scholar 

  • Doolittle D. P., Baumann N., and Chernoff G. (1981) Allelism of two myelin deficiency mutations in the mouse.J. Hered. 72, 285.

    PubMed  CAS  Google Scholar 

  • Doolittle D. P. and Schweikart K. M. (1977) Myelin deficient, a new neurological mutant in the mouse.J. Hered. 68, 331–332.

    PubMed  CAS  Google Scholar 

  • Drummond R. J. (1979) Purification of 2′,3′-cyclic nucleotide 3′-phosphohydrolase from bovine brain by immunoaffinity chromatography: further biochemical characterization of the protein.J. Neurochem. 33, 1143–1150.

    PubMed  CAS  Google Scholar 

  • Drummond R. J. and Dean G. (1980) Comparison of 2′:3′-cyclic nucleotide 3′-phosphodiesterase and the major component of the Wolgram protein W1.J. Neurochem. 35, 1155–1165.

    PubMed  CAS  Google Scholar 

  • Druse M. J., Brady R. O., and Quarles R. H. (1974) Metabolism of a myelin-associated glycoprotein in developing rat brain.Brain Res. 76, 423–434.

    PubMed  CAS  Google Scholar 

  • Dubois-Dalcq M., Behar T., Hudson L., and Lazzarini R. A. (1986a) Emergence of three myelin proteins in oligodendrocytes cultured without neurons.J. Cell Biol. 102, 384–392.

    PubMed  CAS  Google Scholar 

  • Dubois-Dalcq M., Kacher B., Hudson L., Behar T., and Lazzarini R. (1986b) The biology of differentiating oligodendrocytes in culture.Trans. Amer. Soc. Neurochem. 17, 256.

    Google Scholar 

  • Dunkley P. R. and Carnegie P. R. (1974) Amino acid sequence of the smaller basic protein from rat brain myelin.Biochem. J. 141, 243–255.

    PubMed  CAS  Google Scholar 

  • Dupouey P., Jacque C., Bourre J. M., Cessilin F., Privat H., and Baumann N. (1979) Immunochemical studies of myelin basic protein inShiverer mouse devoid of major dense line of myelin.Neurosci. Lett. 12, 113–118.

    PubMed  CAS  Google Scholar 

  • Eicher E. M. and Hoppe P. C. (1973) Use of chimeras to transmit lethal genes in the mouse and to demonstrate allelism of the two X-linked male lethal genesjp andmsd.J. Exp. Zool. 183, 181–184.

    PubMed  CAS  Google Scholar 

  • Einstein E., Dalal K. B., and Csejtey J. (1970) Biochemical maturation of the central nervous system. II. Protein and proteolytic enzyme changes.Brain Res. 18, 35–49.

    PubMed  CAS  Google Scholar 

  • Endo T. and Hidaka H. (1980) Ca2+—calmodulin dependent phosphorylation of myelin isolated from rabbit brain.Biochem. Biophys. Res. Comm. 97, 553–558.

    PubMed  CAS  Google Scholar 

  • Eng L. F., Chao F. C., Gerstl B., Pratt D., and Tavaststjerna M. G. (1968) The maturation of human white matter myelin fractionation of the myelin membrane proteins.Biochemistry 7, 4455–4465.

    PubMed  CAS  Google Scholar 

  • Eylar E. H. (1970) Amino acid sequence of the basic protein of the myelin membrane.Proc. Natl. Acad. Sci. USA 67, 1425–1431.

    PubMed  CAS  Google Scholar 

  • Fagg G. E. (1979) Thequaking mouse: regional variations in the content and protein composition of myelin isolated from the central nervous system.Neurosci. 4, 973–978.

    CAS  Google Scholar 

  • Fahim S. and Riordan J. R. (1986) Lipophilin (PLP) gene in X-linked myelin disorders.J. Neurosci. Res. 16, 303–310.

    PubMed  CAS  Google Scholar 

  • Flynn T. J., Deshmukh D. S., and Pieringer R. A. (1977) Effect of altered thyroid function on galactosyl diacylglycerol metabolism in myelinating rat brain.J. Biol. Chem 252, 5864–5870.

    PubMed  CAS  Google Scholar 

  • Folch J. and Lees M. (1951) Proteolipides, a new type of tissue lipoprotein.J. Biol. Chem. 191, 807–817.

    PubMed  CAS  Google Scholar 

  • Frail D. E. and Braun P. E. (1984) Two developmentally regulated messenger RNAs differing in their coding region may exist for the myelin-associated glycoprotein.J. Biol. Chem. 259, 14857–14862.

    PubMed  CAS  Google Scholar 

  • Frail D. E. and Braum P. E. (1985) Abnormal expression of the myelin-associated glycoprotein in the central nervous system of dysmyelinating mutant mice.J. Neurochem. 45, 1071–1075.

    PubMed  CAS  Google Scholar 

  • Friedman E., Nilaver G., Carmel P., Perlow M., Spatz L., and Latov N. (1986) Myelination by transplanted fetal and neonatal oligodendrocytes in a dysmyelinating mutant.Brain Res. 387, 142–146.

    Google Scholar 

  • Friedrich Jr. V. L. (1974) The myelin deficit inquakingi mice.Brain Res. 82, 168–178.

    PubMed  Google Scholar 

  • Gagnon J., Finch P. R., Wood D. D., and Moscarello M. A. (1971) Isolation of a highly purified myelin protein.Biochemistry 10, 4756–4763.

    PubMed  CAS  Google Scholar 

  • Gandy G., Jacobson W., and Sidman R. (1973) Inhibition of a transmethylation reaction in the central nervous system—an experimental model for subacute combined degeneration of the cord.J. Physiol. (Lond) 233, 1P-3P.

    CAS  Google Scholar 

  • Gansmuller A., Lachapelle F., Baron-Van Evercooren A., Hauw J. J., Baumann N., and Gumpel M. (1986) Transplantations of newborn CNS fragments into the brain ofshiverer mutant mice: extensive myelination by transplanted oligodendrocytes.Dev. Neurosci. 8, 197–207.

    PubMed  CAS  Google Scholar 

  • Gardinier M. V. and Macklin W. B. A comparison of PLP gene expression injp andjp msd mice (submitted).

  • Gardinier M. V., Macklin W. B., Diniak A. J., and Deininger P. L. (1986) Characterization of myelin proteolipid mRNAs in normal andjimpy mice.Mol. Cell. Biol. 6, 3755–3762.

    PubMed  CAS  Google Scholar 

  • Garwood M. M., Gilbert W. R., and Agrawal H. C. (1983) In vivo acylation of proteolipid protein and DM-20 in myelin and myelin subfractions of developing rat brain: immunoblot identification of acylated PLP and DM-20.Neurochem. Res. 8, 649–659.

    PubMed  CAS  Google Scholar 

  • Ginalski-Winkelman H., Guillermina A., and Matthieu J.-M. (1983) In vitro myelin basic protein synthesis in the PNS and CNS of myelin deficient (mld) mutant mice.Brain Res. 277, 386–388.

    Google Scholar 

  • Greenfield S., Brostoff S., and Hogan E. (1977) Evidence for defective incorporation of proteins in myelin of thequaking mutant mouse.Brain Res. 120, 507–515.

    PubMed  CAS  Google Scholar 

  • Greenfield S., Norton W. T., and Morell P. (1971)Quaking mouse: Isolation and characterization of myelin protein.J. Neurochem. 18, 2219–2128.

    Google Scholar 

  • Greenfield S., Williams N. I., White M., Brostoff S. W., and Hogan E. L. (1979) Proteolipid protein: synthesis and assembly intoquaking mouse myelin.J. Neurochem. 32, 1647–1651.

    PubMed  CAS  Google Scholar 

  • Gumpel M., Baumann N., Raoul M., and Jacque C. (1983) Myelination of the central nervous system axons by oligodendrocytes from neural tissue transplanted into newborn mice brains.Neurosci. lett. 37, 307–312.

    PubMed  CAS  Google Scholar 

  • Gumpel M., Lachapelle F., Jacque C., and Baumann N. (1985) Central nervous tissue transplantation into mouse brain: differentiation of myelin from transplanted oligodendrocytes.Neuronal Grafting in the Mammalian CNS, (Bjorklund A. and Stenevi U., eds.), Elsevier, Amsterdam.

    Google Scholar 

  • Hammerberg C. and Klein J. (1975) Linkage relationships of markers on chromosome 17 of the house mouse.Genet. Res. 26, 203–213.

    PubMed  CAS  Google Scholar 

  • Hertz L., Chaban G., and Hertz E. (1980) Abnormal metabolic response to excess potassium in astrocytes from thejimpy mouse, a convulsing neurological mutant.Brain Res. 181, 482–487.

    PubMed  CAS  Google Scholar 

  • Hogan E. L. and Greenfield S. (1984) Animal models of genetic disorders of myelin,Myelin, second edition, Morell P., ed., Plenum, NY, pp. 489–534.

    Google Scholar 

  • Holley J. A. and Yu R. K. (1987) Localization of glycoconjugates recognized by the HNK-1 antibody in mouse and chick embryos during early neural development.Dev. Neurosci. 9, 105–119.

    PubMed  CAS  Google Scholar 

  • Hudson L. D., Berndt J. A., Puckett C., Kozak C. A. and Lazzarini R. A. (1987) Aberrant splicing of proteolipid protein mRNA in the dysmyelinatingjimpy mutant mouse.Proc. Natl. Acad. Sci. USA 84, 1454–1458.

    PubMed  CAS  Google Scholar 

  • Inoue Y., Mikoshiba K., Yokoyama M., Inoue K., Terashima T., Nomura T., and Tsukada Y. (1986) Alteration of the primary pattern of central myelin in chimaeric environment—study ofshiverer; wild-typechimaeras.Dev. Brain Res. 26, 239–247

    Google Scholar 

  • Inoue Y., Nakamura R., Mikoshiba K., and Tsukada Y. (1981) Fine structure of the central myelin sheath in the myelin deficient mutantshiverer mouse, with special reference to the pattern of myelin formation by oligodendroglia.Brain Res. 219, 85–94.

    PubMed  CAS  Google Scholar 

  • Inuzuka T., Johnson D., and Quarles R. H. (1987) Myelin-associated glycoprotein in the central and peripheral nervous system ofquaking mice.J. Neurochem. 49, 597–602.

    PubMed  CAS  Google Scholar 

  • Jacque C., Delassalle A., Raoul M., and Baumann N. (1983) Myelin basic protein deposition in the optic and sciatic nerves of dysmyelinating mutantsquaking, jimpy, trembler, MLD, andshiverer during development.J. Neurochem. 41, 1335–1340.

    PubMed  CAS  Google Scholar 

  • Jacque C., Privat A., Dupouey P., Bourre J. M., Bird T., and Baumann N. (1978)Shiverer mouse: a dysmyelinating mutant with absence of major dense line and basic protein in myelin.Proc. Eur. Soc. Neurochem. 1, 131.

    Google Scholar 

  • Kahn S., Tansey F. A., and Cammer W. (1986) Biochemical and immunocytochemical evidence for a deficiency of normal interfascicular oligodendroglia in the CNS of the dysmyelinating mutant (md) rat.J. Neurochem. 47, 1061–1065.

    PubMed  CAS  Google Scholar 

  • Kamholz J., deFerra F., Puckett C., and Lazzarini R. (1986) Identification of three forms of human myelin basic protein by cDNA cloning.Proc. Natl. Acad. Sci. USA. 83, 4962–4966.

    PubMed  CAS  Google Scholar 

  • Kanfer J., Parenty M., Goujet-Zalc C., Monge M., Bernier L., Campagnoni A. T., Dautigny A., and Zalc B. Developmental expression of myelin proteolipid, basic protein and 2′, 3′-cyclic nucleotide 3′-phosphodiesterase transcripts in different rat brain regions. (Submitted).

  • Karin N. J. and Waehnneldt T. V. (1985) Biosynthesis and insertion of Wolfgram protein into optic nerve membranes.Neurochem. Res. 10, 897–907.

    PubMed  CAS  Google Scholar 

  • Keen P., Osborne R. H., and Pehrson U. M. M. (1976) Respiration and metabolic compartmentation in brain slices from a glia-deficient mutant, thejimpy mouse.J. Physiol. (Lond.) 245, 22–33.

    Google Scholar 

  • kerlero de Rosbo N., Carnegie P. R., Bernard C. C. A., Linthicum D. S. (1984) Detection of various forms of brain myelin basic protein in vertebrates by electroimmunoblotting.Neurochem. Res. 9, 1359–1369.

    PubMed  CAS  Google Scholar 

  • Kerner A.-L. and Carson J. H. (1984) Effect of thejimpy mutation on expression of myelin proteins in heterozygous and hemizygous mouse brain.J. Neurochem. 43, 1706–1715.

    PubMed  CAS  Google Scholar 

  • Kerner A.-L. and Carson J. H. (1986)Shiverer-jimpy double mutant mice. I. Biochemical evidence for reciprocal intergenic suppression.Brain Res. 374, 45–53.

    PubMed  CAS  Google Scholar 

  • Kim S., Tuck M., Ho L., Campagnoni A. T., Barbarese E., Knobler R. L., Lublin F. D., Chanderkar L. P., and Paik W. K. (1986) Myelin basic proteinspecific protein methylase I activity inshiverer mutant mouse brain.J. Neurosci. Res. 16, 357–365.

    PubMed  CAS  Google Scholar 

  • Kim S., Tuck M., Kim M., Campagnoni A. T., and Paik W. (1984) Studies of myelin basic proteinspecific protein methylase I in various dysmyelinating mutant mice.Biochem. Biophys. Res. Comm. 123, 468–474.

    PubMed  CAS  Google Scholar 

  • Kimura M., Inoko H., Katsuki M., Ando A., Sato T., Hirose T., Takashima H., Inayama S., Okano H., Takamatsu K., Mikoshiba K., Tsukada Y., and Watanabe I. (1985) Molecular genetic analysis of myelin-deficient mice:shiverer mutant mice show deletion in gene(s) coding for myelin basic protein.J. Neurochem. 44, 692–696.

    PubMed  CAS  Google Scholar 

  • Knapp P. E., Skoff R. P., and Redstone D. W. (1986) Oligodendroglial cell death injimpy mice: an explanation for the myelin deficit.J. Neurosci. 6, 2813–2822.

    PubMed  CAS  Google Scholar 

  • Kobayashi T., Nakaza T., Negami A., Nakamura S., and Yamamura H. (1984) Phosphorylation of myelin basic protein by glycogen phosphorylase kinase.FEBS Lett. 169, 224–228.

    PubMed  CAS  Google Scholar 

  • Konat G. (1981) Intracellular translocation of newly synthesized myelin proteins in the rat brain stem slices.Exp. Neurol. 73, 254–266.

    PubMed  CAS  Google Scholar 

  • Konat G., Gantt G., and Hogan E. L. (1986) Acylation of myelin proteolipid protein in subcellular fractions of rat brainstem.Neurochem. Int. 9, 545–549.

    CAS  Google Scholar 

  • Kozak M. (1981) Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes.Nuc. Acids Res. 9, 5233–5252.

    CAS  Google Scholar 

  • Kronquist K. E., Crandall B. E., Macklin W. B., and Campagnoni A. T. (1987) Expression of myelin proteins in the developing human spinal cord: cloning and sequencing of human proteolipid protein cDNA.J. Neurosci. Res. 18, 395–401.

    PubMed  CAS  Google Scholar 

  • Kruse F., Keihauer G., Faissner A., Timpl R., and Schachner M. (1985) The J1 glycoprotein-A novel nervous system cell adhesion molecule of the L2/HNK1 family.Nature 316, 146–148.

    PubMed  CAS  Google Scholar 

  • Kruse F., Mailhammer R., Wernecke H., Faissner A., Sommer I., Gordis C. and Schachner M. (1984) Neural cell adhesion molecules and myelin-associated glycoprotein share a common carbohydrate moiety recognized by monoclonal antibodies L2 and HNK-1.Nature,311, 153–155.

    PubMed  CAS  Google Scholar 

  • Kurihara T., Fowler A. V., and Takahashi Y. (1987) cDNA cloning and amino acid sequence of bovine brain 2′,3′-cyclic-nucleotide 3′-phosphodiesterase.J. Biol. Chem. 262, 3256–3261.

    PubMed  CAS  Google Scholar 

  • Kurihara T., Nussbaum J. L., and Mandel P. (1969) 2′,3′-Cyclic nucleotide 3′ phosphohydrolase in the brain of the “jimpy” mouse, a mutant with deficient myelination.Brain Res. 13, 401–403.

    PubMed  CAS  Google Scholar 

  • Kurihara T., Nussbaum J. L., and Mandel P. (1970) 2′-3′-Cyclic nucleotide 3′phosphoydrolase in brains of mutant mice with deficient myelination.J. Neurochem. 17, 993–997.

    PubMed  CAS  Google Scholar 

  • Kurihara T. and Tsukada Y. (1967) The regional and subcellular distribution of 2′,3′-cyclic nucleotide 3′-phosphohydrolase in the central nervous system.J. Neurochem. 14, 1167–1174.

    PubMed  CAS  Google Scholar 

  • Kurihara T. and Tsukada Y. (1968) 2′,3′-cyclic nucleotide 3′-phosphohydrolase in the developing chick brain and spinal cord.J. Neurochem. 15, 827–832.

    PubMed  CAS  Google Scholar 

  • Lachapelle F., Gumpel M., Baulac M., Jacque C., Duck P., and Baumann N. (1983, 1984). Transplantation of CNS fragments into the brain ofshiverer mutant mice: Extensive myelination by transplanted oligodendrocytes 1. Immunohistochemical studies.Dev. Neurosci. 6, 325–334.

    PubMed  Google Scholar 

  • Lai C., Brow M. A., Nave K.-A., Noronha A. B., Quarles R. H., Bloom F. E., Milner R. J., and Sutcliffe J. G. (1987) Two forms of 1B236/myelin-associated glycoprotein, a cell adhesion molecule for postnatal neural development, are produced by alternative splicing.Proc. Natl. Acad. Sci. USA 84, 4227–4341.

    Google Scholar 

  • Lee H. W., Kim S., and Paik W. K. (1977) S-adenosylmethionine: protein-arginine methyltransferase: purification and mechanism of the enzyme.Biochemistry 16, 78–85.

    PubMed  CAS  Google Scholar 

  • Lees M. B. (1982) Proteolipids.Scand. J. Immunol. 15, 147–166.

    Google Scholar 

  • Lees M. B. and Macklin W. B. (19880 Myelin proteolipid protein,Functional and Clinical Aspects of Neuronal and Glial Proteins, Neurobiological Research, vol. 2, (Marangos P. J., Campbell I., and Cohen R. M., eds) Academic Press, pp. 267–294.

  • Lees M. B. and Paxman S. A. (1974) Myelin proteins from different regions of the central nervous system.J. Neurochem. 23, 825–831.

    PubMed  CAS  Google Scholar 

  • Lees M. B. and Sapirstein V. S. (1983) Myelin-associated enzymes.Handbook of Neurochemistry, vol. 4, (2nd ed.), Lajtha A., ed., Plenum NY, pp 435–460.

    Google Scholar 

  • Lepage P., Helynck G., Chu J.-Y., Luu B., Sorokine O., Trifilieff E., and Van Dorsselaer A. (1986) Purification and characterization of minor brain proteolipids: use of fast atom bombardmentmass spectrometery for peptide sequencing.Biochimie 68, 669–686.

    PubMed  CAS  Google Scholar 

  • Lerner P., Campagnoni A. T., and Sampugna J. (1974) Proteolipids in the developing brains of normal mice and myelin deficient mutants.J. Neurochem. 22, 163–170.

    PubMed  CAS  Google Scholar 

  • Lyon M. F. (1972) X-chromosome inactivation and developmental patterns in mammals.Biol. Rev. 47, 1–35.

    PubMed  CAS  Google Scholar 

  • Mack S. R. and Szuchet S. (1981) Synthesis of myelin glycosphingolipids by isolated oligodendrocytes in tissue culture.Brain Res. 214, 180–185.

    PubMed  CAS  Google Scholar 

  • Macklin W. B., Campagnoni C. W., Deininger P. L., and Gardinier M. V. (1987) Structure and expression of the mouse myelin proteolipid protein gene.J. Neurosci. Res. 18, 383–394.

    PubMed  CAS  Google Scholar 

  • Macklin W. B., Oberfield E., Lees M. B. (1983, 1984) Electroblot analysis of rat myelin proteolipid protein and basic protein during development.Dev. Neurosci. 6, 161–168.

    PubMed  Google Scholar 

  • Macklin W. B. and Pfeiffer S. E. (1983) Myelin proteolipid: Time course in primary cultures of fetal rat brain.Trans. Am. Soc. Neurochem. 14, 212.

    Google Scholar 

  • Macklin W. B. and Weill C. L. (1985) Appearance of myelin proteins during development in the chick central nervous system.Dev. Neurosci. 7, 170–178.

    PubMed  CAS  Google Scholar 

  • Macklin W. B., Weill C. L., and Deininger P. L. (1986) Expression of myelin proteolipid and basic protein mRNAs in cultured cells.J. Neurosci. Res. 16, 203–217.

    PubMed  CAS  Google Scholar 

  • Magno-Sumbilla C. and Campagnoni A. T. (1977) Factors affecting the electrophoretic analysis of myelin proteins: application to changes occurring during brain development.Brain Res. 126, 131–148.

    PubMed  CAS  Google Scholar 

  • Martenson R. E., Deibler G. E., Kies M. W., McKneally S. S., Shapira R., and Kibler R. F. (1972) Differences between the two myelin basic proteins of the rat central nervous system: a deletion in the smaller protein.Biochim Biophys. Acta 263, 193–203.

    PubMed  CAS  Google Scholar 

  • Martenson R. E., Law M. J., and Deibler G. E. (1983) Identification of multiple in vivo phosphorylation sites in rabbit myelin basic protein.J. Biol. Chem. 258, 930–937.

    PubMed  CAS  Google Scholar 

  • Martini R. and Schachner M. (1986) Immunoelectron microscopic localization of neural cell adhesion molecules (L1,N-CAM, and MAG) and their shared carbohydrate epitope and myelin basic protein in developing sciatic nerve.J. Cell. Biol. 103, 2439–2448.

    PubMed  CAS  Google Scholar 

  • Marton L. S. and Stefansson K. (1984) Developmental alterations in molecular weights of proteins in the human central nervous system that react with antibodies against myelin-associated glycoprotein.J. Cell Biol. 99, 1642–1646.

    PubMed  CAS  Google Scholar 

  • Mattei M. G., Alliel P. M., Dautigny A., Passage E., Pham-Dinh D., Mattei J. F., and Jolles P. (1986) The gene encoding for the major brain proteolipid (PLP) maps on the q-22 band of the human X chromosome.Hum. Genet. 72, 352–353.

    PubMed  CAS  Google Scholar 

  • Matthieu J.-M. (1978) Proteins from sciatic-nerve myelin inquaking andjimpy mice.Biochem J. 173, 989–991.

    PubMed  CAS  Google Scholar 

  • Matthieu J.-M., Almazan G., and Waehneldt T. V. (1983, 1984) Intrinsic myelin proteins are normally synthesized in vitro in themyelin-deficient (mld) mutant mouse.Dev. Neurosci. 6, 246–250.

    PubMed  Google Scholar 

  • Matthieu J.-M., Brady R. O., and Quarles R. H. (1974) Developmental change in a myelin-associated glycoprotein: comparative study in rodents.Dev. Biol. 37, 146–152.

    PubMed  CAS  Google Scholar 

  • Matthieu J.-M., Ginalski H., Friede R. L., and Cohen S. R. (1980) Low myelin basic protein levels and normal myelin in peripheral nerves of myelin deficient mutant mice (mld).Neurosci. 5, 2315–2320.

    CAS  Google Scholar 

  • Matthieu J.-M., Ginalski-Winkelmann H., and Jacque C. (1981) Similarities and dissimilarities between two myelin deficient mutant mice,shiverer andmld.Brain Res. 214, 219–222.

    PubMed  CAS  Google Scholar 

  • Matthieu J.-M., Honegger P., Favrod P., Gautier P., and Dolivo M. (1979) Biochemical characterization of myelin fractions isolated from rat brain aggregating cell cultures.J. Neurochem. 32, 869–881.

    PubMed  CAS  Google Scholar 

  • Matthieu J.-M., Roch J.-M., Omlin F. X., Rambaldi I., Almazan G., and Braun P. E. (1986) Myelin instability and oligodendrocyte metabolism inmyelin-deficient mutant mice.J. Cell Biol. 103, 2673–2682.

    PubMed  CAS  Google Scholar 

  • Matthieu J.-M., Widmer S., and Herschkowitz N. (1973) Biochemical changes in mouse brain composition during myelination.Brain Res. 55, 391–402.

    PubMed  CAS  Google Scholar 

  • McCarthy K. D. and deVellis J. (1980) Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissues.J. Cell Biol. 85, 890–902.

    PubMed  CAS  Google Scholar 

  • McGarry R. C., Helfand S. L., Quarles R. H., and Roder J. C. (1983) Recognition of myelin-associated glycoprotein by the monoclonal antibody HNK-1.Nature 306, 376–378.

    PubMed  CAS  Google Scholar 

  • McMorris F. A., Kim S. U., and Sprinkle T. J. (1984) Intracellular localization of 2′,3′-cyclic nucleotide 3′-phosphohydrolase in rat oligodendrocytes and C6 glioma cells, and effect of cell maturation and enzyme induction on localization.Brain Res. 292, 123–131.

    PubMed  CAS  Google Scholar 

  • Meier C. and Bischoff A. (1975) Oligodendroglial cell development injimpy mice and controls: an electron-microscopic study in the optic nerve.J. Neurolog. Sci. 26, 517–528.

    CAS  Google Scholar 

  • Meier C. and MacPike A. D. (1970) A neurological mutation (msd) of the mouse causing a deficiency of myelin synthesis.Exp. Brain Res. 10, 512–525.

    PubMed  CAS  Google Scholar 

  • Mentaberry A., Adesnik M., Atchison M., Norgard E. M., Alvarez F., Sabatini D. D., and Colman D. R. (1986) Small basic proteins of myelin from central and peripheral nervous systems are encoded by the same gene.Proc. Natl. Acad. Sci. USA 83, 1111–1114.

    PubMed  CAS  Google Scholar 

  • Mikoshiba K., Aoki E., and Tsukada Y. (1980a) 2′–3′-cyclic nucleotide 3′-phosphohydrolase activity in the central nervous system of a myelin deficient mutant (shiverer).Brain Res. 192, 195–204.

    PubMed  CAS  Google Scholar 

  • Mikoshiba K., Kohasaka S., Hayakawa T., Takamatsu K., and Tsukada Y. (1985) Immunohistochemical localization of 2′,3′-cyclic nucleotide 3′-phosphodiesterase and myelin basic protein in the central nervous system of thejimpy and the normal mouse.J. Neurochem. 44, 686–691.

    PubMed  CAS  Google Scholar 

  • Mikoshiba K., Nagaike K., Aoki E., and Tsukada Y. (1979) Biochemical and immunohistochemical studies on dysmyelination ofquaking mutant mice in vivo and in vitro.Brain Res. 177, 287–299.

    PubMed  CAS  Google Scholar 

  • Mikoshiba K., Nagaike K., and Tsukada Y. (1980) Subcellular distribution and developmental change of 2′,3′-cyclic nucleotide 3′-phosphohydrolase in the central nervous system of themyelin-deficient shiverer mutant mice.J. Neurochem. 35, 465–470.

    PubMed  CAS  Google Scholar 

  • Mikoshiba K., Yokoyama Y., Inoue Y., Takamatsu K., Tsukada Y., and Nomura T. (1982) Oligodendrocyte abnormalities inshiverer mouse mutant are determined in primary chimaeras.Nature 299, 357–359.

    PubMed  CAS  Google Scholar 

  • Milner R. J., Lai C. Nave K.-A., Lenior D., Ogata J., and Sutcliffe J. G. (1985) Nucleotide sequences of two mRNAs for rat brain myelin proteolipid protein.Cell 42, 931–939.

    PubMed  CAS  Google Scholar 

  • Miskimins R. and Yu R. K. (1986) Developmental expression of myelin basic protein mRNA in a hypermyelinating mouse.J. Neurosci. Res. 16; 219–225.

    PubMed  CAS  Google Scholar 

  • Miyake M. (1975) Methylases of myelin basic protein and histone in rat brain.J. Neurochem. 24, 909–915.

    PubMed  CAS  Google Scholar 

  • Miyamoto E. and Kakiuchi S. (1974) In vitro and in vivo phosphorylation of myelin basic protein by exogenous and endogenous adenosine 3′∶5′-monophosphate-dependent protein kinases in brain.J. Biol. Chem. 249, 2769–2777.

    PubMed  CAS  Google Scholar 

  • Miyamoto E., Kakiuchi S., and Kakimoto Y. (1974) In vitro and in vivo phosphorylation of myelin basic protein by cerebral protein kinase.Nature 249, 150–151.

    PubMed  CAS  Google Scholar 

  • Molineaux S. M., Engh H., deFerra F. Hudson L. and Lazzarini R. A. (1986) Recombination within the myelin basic protein gene created the dysmyelinatingshiverer mouse mutant.Proc. Natl. Acad. Sci. USA 83, 7542–7546.

    PubMed  CAS  Google Scholar 

  • Monge M., Kadiiski D., Jacque C. M., and Zalc B. (1986) Oligodendroglial expression and deposition of four major myelin constituents in the myelin sheath during development: an in vivo study.Dev. Neurosci. 8, 222–235.

    PubMed  CAS  Google Scholar 

  • Morell P., Greenfield S., Costantino-Ceccarini E., and Wisniewski H. (1972) Changes in the protein composition of mouse brain myelin during development.J. Neurochem. 19, 2545–2554.

    PubMed  CAS  Google Scholar 

  • Morell P., Lipkind R., and Greenfield S. (1973) Protein composition of myelin from brain and spinal cord of several species.Brain Res. 58, 510–514.

    PubMed  CAS  Google Scholar 

  • Morell P. (1984)Myelin, Plenum, NY, 545 pp

    Google Scholar 

  • Morello D., Dautigny A., Pham-Dinh D., and Jolles P. (1986) Myelin proteolipid protein (PLP and DM-20) transcripts are deleted injimpy mutant mice.EMBO J. 5, 3489–3493.

    PubMed  CAS  Google Scholar 

  • Murray N. and Steck A. J. (1984) Impulse conduction regulates myelin basic protein phosphorylation in rat optic nerve.J. Neurochem. 43, 243–248.

    PubMed  CAS  Google Scholar 

  • Naismith A. L., Hoffman-Chudzik E., Tsui L.-C., and Riordan J. R. (1985) Study of the expression of myelin proteolipid protein (lipophilin) using a cloned complementary DNA.Nucl. Acids Res. 13, 7413–7425.

    PubMed  CAS  Google Scholar 

  • Nave K.-A., Lai C., Bloom F. E., Milner R. J. (1986)Jimpy mutant mouse: a 74 base deletion in the mRNA for myelin proteolipid protein and evidence for a primary defect in RNA splicing.Proc. Natl. Acad. Sci. USA 83, 9264–9268.

    PubMed  CAS  Google Scholar 

  • Nave K.-A., Lai C., Bloom F. E., and Milner R. J. (1987a) Splice site selection in the proteolipid protein (PLP) gene transcript and primary structure of the DM-20 protein of CNS myelin.Proc. Natl. Acad Sci. USA 84, 5665–5669.

    PubMed  CAS  Google Scholar 

  • Nave K.-A., Lai C., Bloom F. E., and Milner R. J. (1987b)Jimpy mutant mice have a genetic defect in splicing of the proteolipid protein (PLP) DM-20 gene transcript.J. Neurochem.,48, S130.

    Google Scholar 

  • Newcombe J., Glynn P., and Cuzner M. L. (1982) The immunological identification of brain proteins on cellulose nitrate in human demyelinating disease.J. Neurochem. 38, 267–274.

    PubMed  CAS  Google Scholar 

  • Newman S. L., Kitamura K., and Campagnoni A. T. (1987a) Identification of a cDNA coding for a fifth form of myelin basic protein in mouse.Proc. Natl. Acad. Sci. USA 84, 886–890.

    PubMed  CAS  Google Scholar 

  • Newman S. L., Kitamura K., Roth H. J., Kronquist K., Kerlero de Rosbo N., Crandall B. F., and Campagnoni A. T. (1987b) Differential expression of the myelin basic protein genes in mouse and human.J. Neurochem. 48, S27.

    Google Scholar 

  • Niebroj-Dobosz I., Fidzianska A., Rafalowska J., and Sawicka E. (1980) Correlative biochemical and morphological studies of myelination in human ontogenesis. I. Myelination in spinal cord.Acta Neuropathol. 49, 145–152.

    PubMed  CAS  Google Scholar 

  • Noble M. and Murray K. (1984) Purified astrocytes promote the in vitro division of a biopotential glial progenitor cell.EMBO J. 3, 2243–2247.

    PubMed  CAS  Google Scholar 

  • Norton W. T. (1984)Oligodendroglia, Plenum, NY, 370 pp.

    Google Scholar 

  • Norton W. T. and Cammer W. (1984) Isolation and characterization of myelin.Myelin, second edition Morell P., ed., Plenum, NY pp. 147–195.

    Google Scholar 

  • Nussbaum J. L. and Mandel P. (1973) Brain proteolipids in neurological mutant mice.Brain Res. 61, 295–310.

    PubMed  CAS  Google Scholar 

  • Nussbaum J. L., Nussbaum F. R., Gensburger C., Aracet E., de los Monteros M. T., Roussel G., and Labourdette G. (1983) Detection of Wolfgram W1 protein, myelin basic proteins and proteolipids in cultured oligodendrocytes by the electro-immunoblotting method.Neurosci. Lett. 40, 111–117.

    PubMed  CAS  Google Scholar 

  • Okano H., Miura M., Moriguchi A. Ikenaka K., Tsukada Y., and Mikoshiba K. (1987) Inefficient transcription of the myelin basic protein gene possibly causes hypomyelination in myelin-deficient mutant mice.J. Neurochem. 48, 470–476.

    PubMed  CAS  Google Scholar 

  • Olafson R. W., Drummond G. I., and Lee J. F. (1969) Studies on 2′,3′-cyclic nucleotide-3′-phosphohydrolase from brain.Can. J. Biochem. 47, 961–966.

    PubMed  CAS  Google Scholar 

  • Omlin F. X. and Anders J. J. (1983) Abnormal cell relationships injimpy mice: electron microscopic and immunocytochemical findings.J. Neurocyt. 12, 767–784.

    CAS  Google Scholar 

  • Paik W. K. and Kim S. (1975) Protein methylation: chemical, enzymological, and biological significance.Adv. Enzymol. 42, 227–286.

    PubMed  CAS  Google Scholar 

  • Park G.-H., Chanderkar L. P., Paik W. K., and Kim S. (1986) Myelin basic protein inhibits histone-specific protein methylase I.Biochem. Biophys. Acta 874, 30–36.

    PubMed  CAS  Google Scholar 

  • Peters A., Palay S. L., and Webster H. deF. (1970)The Fine Structure of the Nervous System. The Cells and their Processes. Harper and Row, NY, 198 pp.

    Google Scholar 

  • Pfeiffer S. E. (1984) Oligodendrocyte development in culture systemsOligodendroglia Norton W. T., ed., Plenum, NY, pp. 233–298.

    Google Scholar 

  • Pfeiffer S. E., Barbarese E., and Bhat S. (1981a) Glial cell lines.Functionally Differentiated Cell Lines. Liss, NY, pp. 141–154.

    Google Scholar 

  • Pfeiffer S. E., Barbarese E., and Bhat S. (1981b) Non-coordinate regulation of myelinogenic parameters in primary cultures of dissociated fetal rat brain.J. Neurosci. Res. 6, 369–380.

    PubMed  CAS  Google Scholar 

  • Poduslo J. F., Quarles R. H., and Brady R. O. (1976) External labeling of galactose in surface membrane glycoproteins of the intact myelin sheath.J. Biol. Chem. 251, 153–158.

    PubMed  CAS  Google Scholar 

  • Popko B., Puckett C., Lai E., Shine H. D., Readhead C., Takahashi N., Hunt III S. W., Sidman R. L., and Hood L. (1987) Myelin deficient mice: expression of myelin basic protein and generation of mice with varying levels of myelin.Cell 48, 713–721.

    PubMed  CAS  Google Scholar 

  • Privat A., Jacque C., Bourre J. M., Dupouey P., and Baumann N. (1979) Absence of the major dense line in myelin of the mutant mouseSheverer.Neurosci. Lett. 12, 107–112.

    PubMed  CAS  Google Scholar 

  • Privat A., Valat J., Lachappelle F., Baumann N., and Fulcrand J. (1982) Radioautographic evidence for the protracted proliferation of glial cells in the central nervous system ofjimpy mice.Dev. Brain Res. 2, 411–416.

    Google Scholar 

  • Quarles R. H. (1979) Glycoproteins in myelin and myelin related membranes,Myelin Chemistry and Biology, Hashim G., ed., Liss Inc., NY., pp 55–77.

    Google Scholar 

  • Quarles R. H. (1983, 1984) Myelin-associated glycoprotein in development and disease.Dev. Neurosci. 6, 285–303.

    PubMed  CAS  Google Scholar 

  • Quarles R. H., Barbarash G. R., Figlewicz D. A., and McIntyre L. J. (1983) Purification of partial characterization of the myelin-associated glycoprotein from adult rat brain.Biochim. Biophys. Acta 757, 140–143.

    PubMed  CAS  Google Scholar 

  • Raff M. C., Abney E. R., and Fok-Seang J. (1985) Reconstitution of a developmental clock in vitro: a critical role for astrocytes in the timing of oligodendrocyte differentiation.Cell 42, 61–69.

    PubMed  CAS  Google Scholar 

  • Raff M. C., Miller R. H., and Noble M. (1983) A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium.Nature 303, 390–396.

    PubMed  CAS  Google Scholar 

  • Readhead C., Popko B., Takahashi N., Shine H. D., Saavedra R. A., Sidman R. L., and Hood L. (1987) Expression of a myelin basic protein gene in transgenicshiverer mice: correction of the dysmyelinating phenotype.Cell 48, 703–712.

    PubMed  CAS  Google Scholar 

  • Roach A., Boylan K., Horvath S., Prusiner S. B., and Hood L. (1983) Characterization of cloned cDNA representing rat myelin basic protein: absence of expression in brain ofshiverer mutant mice.Cell 34, 799–806.

    PubMed  CAS  Google Scholar 

  • Roach A., Takahashi N., Pravtcheva D., Ruddle F. and Hood L. (1985) Chromosomal mapping of mouse myelin basic protein gene and structure and transcription of the partially deleted gene inshiverer mutant mice.Cell 42, 149–155.

    PubMed  CAS  Google Scholar 

  • Roch J.-M., Brown-Luedi M., Cooper B. J., and Matthieu J.-M. (1986) Mice heterozygous for themld mutation have intermediate levels of myelin basic protein mRNA and its translation products.Mol. Brain Res. 1, 137–144.

    CAS  Google Scholar 

  • Rome L. H., Bullock P. N., Chiappelli F., Cardwell M., Adinolfi A. M., and Swanson D. (1986) Synthesis of a myelin-like membrane by oligodendrocytes in culture.J. Neurosci. Res. 15, 49–65.

    PubMed  CAS  Google Scholar 

  • Rosenfeld J. and Friedich Jr. V. L. (1986) Oligodendrocyte production and myelin recovery in heterozygousjimpy mice: an autoradiographic study.Int. J. Dev. Neurosci. 4, 179–187.

    PubMed  CAS  Google Scholar 

  • Roth H. J., Hunkeler M. J., and Campagnoni A. T. (1985) Expression of myelin basic protein genes in several dysmyelinating mouse mutants during early postnatal brain development.J. Neurochem. 45, 572–580.

    PubMed  CAS  Google Scholar 

  • Roth H. J., Kronquist K. E., Kerlero de Rosbo N., Crandall B. F., and Campagnoni A. T. (1987) Evidence for the expression of four myelin basic protein variants in the developing human spinal cord through cDNA cloning.J. Neurosci. Res. 17, 321–328.

    PubMed  CAS  Google Scholar 

  • Roth H. J., Kronquist K., Pretorius P. J., Crandall P. J., Crandall B. F., and Campagnoni A. T. (1986) Isolation and characterization of a cDNA coding for a novel human 17.3 K myelin basic protein (MBP) variant.J. Neurosci. Res. 16, 227–238.

    PubMed  CAS  Google Scholar 

  • Sakellaridis N., Mangoura D., and Vernadakis A. (1986) Effects of neuron-conditioned medium and fetal calf serum content on glial growth in dissociated cultures.Dev. Brain Res. 27, 31–41.

    CAS  Google Scholar 

  • Salzer J. L., Holmes W. P., and Colman D. R. (1987) The amino acid sequences of the myelin-associated glycoproteins: homology to the immunoglobulin gene superfamily.J. Cell Biol. 104, 957–965.

    PubMed  CAS  Google Scholar 

  • Sarlieve L. L., Fabre M., Susz J., and Matthieu J.-M. (1983) Investigations on myelin in vitro: IV. “Myelin-Like” or premyelin structures in cultures of dissociated brain cells from 14–15 day-old embryonic mice.J. Neurosci. Res. 10, 191–210.

    PubMed  CAS  Google Scholar 

  • Sarlieve L. L., Farooqui A. A., Rebel G., and Mandel P. (1976) Arylsulphatase A and 2′,3′-cyclic nucleotide 3′-phosphohydrolase activities in the brains of myelin deficient mutant mice.Neurosci. 1, 519–522.

    CAS  Google Scholar 

  • Saxe D. F., Takahashi N., Hood L., and Simon M. I. (1985) Localization of the human myelin basic protein gene (MBP) to region 18q22→qter byin situ hybridization.Cytogenet. Cell Genet. 39, 246–249.

    PubMed  CAS  Google Scholar 

  • Scott J. M., Wilson P., Dinn J. J., Weir D. G. (1981) Pathogenesis of subacute combined degeneration: a result of methyl group deficiency.Lancet II, 334–337.

    Google Scholar 

  • Shanker G., Amur S. G., and Pieringer R. A. (1985) Investigations on myelinogenesis in vitro: A study of the critical period at which thyroid hormone exerts its maximum regulatory effect on the developmental expression of two myelin associated markers in cultured brain cells from embryonic mice.Neurochem. Res. 10, 617–625.

    PubMed  CAS  Google Scholar 

  • Shanker G., Campagnoni A. T., and Pieringer R. A. (1987) Investigations on myelinogenesis in vitro: Developmental expression of myelin basic protein mRNA and its regulation by thyroid hormone in primary cerebral cell cultures from embryonic mice.J. Neurosci. Res. 17, 220–224.

    PubMed  CAS  Google Scholar 

  • Shanker G. and Pieringer R. A. (1983) Effect of thyroid hormone on the synthesis of sialosyl galactosylceramide (GM4) in myelinogenic cultures of cells dissociated from embryonic mouse brain.Develop. Brain Res. 6, 169–174.

    CAS  Google Scholar 

  • Shanker G., Rao G. S., and Pieringer R. A. (1984) Investigations on myelinogenesis in vitro: Regulation of 5′-nucleotidase activity by thyroid hormone in cultures dissociated cells from embryonic mouse brain.J. Neurosci. Res. 11, 263–270.

    PubMed  CAS  Google Scholar 

  • Shashoua V. E., Jungalwala C. B., Chou D. K. H., and Moore M. E. (1986) Sulfated glucuronyl glycoconjugates in ependymins of fish and human CSF.Trans. Am. Soc. Neurochem. 17, 148.

    Google Scholar 

  • Sheedlo H. J. and Siegel G. J. (1986) Myelinassociated glycoprotein (MAG) in the CNS of adultshiverer (Shi/Shi) mice.J. Neurosci. Res. 16, 629–641.

    PubMed  CAS  Google Scholar 

  • Sidman R. L., Conover D. S., and Carson J. H. (1985)Shiverer gene maps near the distal end of chromosome 18 in the house mouse.Cytogenet. Cell Genet. 39, 241–245.

    PubMed  CAS  Google Scholar 

  • Sidman R. L., Dickie M. M., and Appel S. H. (1964) Mutant mice (quaking andjimpy) with deficient myelination in the central nervous system.Science 144, 309–310.

    PubMed  CAS  Google Scholar 

  • Singh H. and Pfeiffer S. E. (1985) Myelin-associated galactolipids in primary cultures from dissociated fetal rat brain: biosynthesis, accumulation, and cell surface expression.J. Neurochem. 45, 1371–1381.

    PubMed  CAS  Google Scholar 

  • Skoff R. P. (1976) Myelin deficit in thejimpy mouse may be due to cellular abnormalities in astroglia.Nature 264, 560–562.

    PubMed  CAS  Google Scholar 

  • Skoff R. P. (1982) Increased proliferation of oligodendrocytes in the hypomyelinated mouse mutant—jimpy.Brain Res. 248, 19–31.

    PubMed  CAS  Google Scholar 

  • Skoff R. P. and Nowicki-Montgomery I. (1981) Expression of mosaicism in females heterozygous forjimpy.Brain Res. 212, 175–181.

    PubMed  CAS  Google Scholar 

  • Skoff R. P., Price D., and Stocks A. (1976a) Electron microscopic autoradiographic studies of gliogenesis in rat optic nerve. I. Cell proliferation.J. Comp. Neurol. 169, 291–312.

    PubMed  CAS  Google Scholar 

  • Skoff R. P., Price D., and Stocks A. (1976b) Electron microscopic autoradiographic studies of gliogenesis in rat optic nerve. II. Time of origin.J. Comp. Neurol. 169, 313–333.

    PubMed  CAS  Google Scholar 

  • Small D. H. and Carnegie P. R. (1982) In vivo methylation of an arginine in chicken myelin basic protein.J. Neurochem. 38, 184–190.

    PubMed  CAS  Google Scholar 

  • Small D. H., Carnegie P. R., and Anderson R. McD. (1981) Cycloleucine-induced vacuolation of myelin is associated with inhibition of protein methylation.Neurosci. Lett. 21, 287–292.

    PubMed  CAS  Google Scholar 

  • Smith M. E. (1968) The turnover of myelin in the adult rat.Biochim. Biophys. Acta 164, 285–293.

    PubMed  CAS  Google Scholar 

  • Sorg B. J. A., Agrawal D., Agrawal H. C., and Campagnoni A. T. (1986) Expression of myelin proteolipid protein and basic protein in normal and dysmyelinating mutant mice.J. Neurochem. 46, 379–387.

    PubMed  CAS  Google Scholar 

  • Sorg B. J. A., Smith M. M., and Campagnoni A. T. (1987) Developmental expression of the myelin proteolipid protein and basic protein mRNAs in normal and dysmyelinating mutant mice.J. Neurochem. 49, 1146–1154.

    PubMed  CAS  Google Scholar 

  • Sparkes R. S., Mohandas T., Heinzmann C., Roth H. J., Klisak I., and Campagnoni A. T. (1987) Assignment of the myelin basic protein gene to human chromosome 18q22-qter.Hum. Genet. 75, 147–150.

    PubMed  CAS  Google Scholar 

  • Sprinkle T. J., Grimes M. J., and Eller A. G. (1980a) Isolation of 2′,3′-cyclic nucleotide 3′-phosphodiesterase from human brain.J. Neurochem. 34, 880–887.

    PubMed  CAS  Google Scholar 

  • Sprinkle T. J., Wells M. R., Garver F. A., and Smith B. D. (1980b) Studies on the Wolfgram high molecular weight CNS myelin proteins: relationship to 2′,3′-cyclic nucleotide 3′-phosphodiesterase.J. Neurochem. 35, 1200–1208.

    PubMed  CAS  Google Scholar 

  • Sprinkle T. J., Zaruba M. E., and McKhann G. M. (1978) Activity of 2′,3′-cyclic-nucleotide 3′-phosphodiesterase in regions of rat brain during development: quantitative relationship to myelin basic protein.J. Neurochem. 30, 309–314.

    PubMed  CAS  Google Scholar 

  • Steck A. J. and Appel S. H. (1974) Phosphorylation of myelin basic protein.J. Biol. Chem. 249, 5416–5420.

    PubMed  CAS  Google Scholar 

  • Steck A. J., Siegrest P., and Herschkowitz N. (1976) Phosphorylation of myelin basic protein by vaccinia virus cores.Nature 263, 436–438.

    PubMed  CAS  Google Scholar 

  • Sternberger N. H. (1984) Patterns of oligodendrocyte function seen by immunocytochemistry,Oligodendroglia, Norton W. T., ed., Plenum NY, pp 125–173.

    Google Scholar 

  • Sternberger N. H., Itoyama Y., Kies M. W., and Webster H. deF. (1978a) Immunocytochemical method to identify basic protein in myelin-forming oligodendrocytes of newborn rat CNS.J. Neurocytol. 7, 251–263.

    PubMed  CAS  Google Scholar 

  • Sternberger N. H., Itoyama Y., Kies M. W., and Wegbster H. DeF. (1978b) Myelin basic protein demonstrated immunocytochemically in oligodendroglia prior to myelin sheath formation.Proc. Natl. Acad. Sci. USA 75, 2521–2524.

    PubMed  CAS  Google Scholar 

  • Sternberger N. H., Quarles R. H., Itoyama Y., and Webster H. deF. (1979) Myelin-associated glycoprotein demonstrated immunocytochemically in myelin and myelin-forming cells of developing rat.Proc. Natl. Acad. Sci. USA 76, 1510–1514.

    PubMed  CAS  Google Scholar 

  • Stoffel W., Schroder W., Hillen H., and Deutzmann R. (1982) Analysis of the primary structure of the strongly hydrophobic brain myelin proteolipid apoprotein (lipophilin) isolation and amino acid sequence determination of proteolytic fragments. Hoppe-Seyler's Z.Physiol. Chem. 363, 1117–1131.

    CAS  Google Scholar 

  • Stoffyn P. and Folch-pi J. (1971) On the type of linkage binding fatty acids present in brain white matter proteolipid apoprotein.Biochem. Biophys. Res. Comm. 44, 157–161.

    PubMed  CAS  Google Scholar 

  • Stoner G. L. (1984) Predicted folding of beta-structure in myelin basic protein.J. Neurochem. 43, 433–447.

    PubMed  CAS  Google Scholar 

  • Sulakhe P. V., Petrali E. H., Davis E. R., and Thiessen B. J. (1980) Calcium ion stimulated endogenous protein kinase catalyzed phosphorylation of basic proteins in myelin subfraction aand myelin-like membrane fraction from rat brain.Biochemistry 19, 5363–5371.

    PubMed  CAS  Google Scholar 

  • Sutcliffe J. G.,(1987) The genes for myelin.Trends in Genetics 3, 73–76.

    CAS  Google Scholar 

  • Sutcliffe J. G., Milner R. J., Shinnick T. M., and Bloom F. E. (1983) Identifying the protein products of brain-specific genes with antibodies to chemically synthesized peptides.Cell 33, 671–682.

    PubMed  CAS  Google Scholar 

  • Szuchet S., Polak P. E., and Yim S. H. (1986) Mature oligodendrocytes cultured in the absence of neurons recapitulate the ontogenic development of myelin membranes.Dev. Neurosci. 8, 208–221.

    PubMed  CAS  Google Scholar 

  • Szuchet S., Stefansson K., Wollmann R. L., Dawson G., and Arnason B. G. W. (1980) Maintenance of isolated oligodendrocytes in long-term culture.Brain Res. 200, 151–164.

    PubMed  CAS  Google Scholar 

  • Szuchet S. and Yim S. H. (1984) Characterization of a subset of oligodendrocytes separated on the basis of selective adherence properties.J. Neurosci. Res. 11, 131–144.

    PubMed  CAS  Google Scholar 

  • Szuchet S., Yim S. H., and Monsma S. (1983) Lipid metabolism of isolated oligodendrocytes maintained in long-term culture mimics events associated with myelinogenesis.Proc. Natl. Acad. Sci. USA 80, 7019–7023.

    PubMed  CAS  Google Scholar 

  • Takahashi N., Roach A., Teplow D. B., Prusiner S. B., and Hood L. (1985) Cloning and characterization of the myelin basic protein gene from mouse: one gene can encode both 14 kd and 18.5 kd MBPs by alternate use of exons.Cell 42, 139–148.

    PubMed  CAS  Google Scholar 

  • Temple S. and Raff M. C. (1985) Differentiation of a bipotential glial progenitor cell in single cell microculture.Nature 313, 223–225.

    PubMed  CAS  Google Scholar 

  • Temple S. and Raff M. C. (1986) Clonal analysis of oligodendrocyte development in culture: Evidence for a developmental clock that counts cell divisions.Cell 44, 773–779.

    PubMed  CAS  Google Scholar 

  • Tennekoon G. I., Cohen S. R., Price D. L., and McKhann G. M. (1977) Myelinogenesis in optic nerve: a morphological, autoradiographic, and biochemical analysis.J. Cell Biol. 72, 604–616.

    PubMed  CAS  Google Scholar 

  • Townsend L. E., Agrawal D., Benjamins J. A., and Agrawal H. C. (1982) In vitro acylation of rat brain myelin proteolipid protein.J. Biol. Chem. 257, 9745–9750.

    PubMed  CAS  Google Scholar 

  • Townsend L. E. and Benjamins J. A. (1983) Effects of monensin on posttranslational processing of myelin proteins.J. Neurochem. 40, 1333–1339.

    PubMed  CAS  Google Scholar 

  • Trapp B. D. and Quarles R. H. (1982) Presence of the myelin-associated glycoprotein correlates with alterations in the periodicity of peripheral myelin.J. Cell Biol. 92, 877–882.

    PubMed  CAS  Google Scholar 

  • Trapp B. D., Quarles R. H., and Griffin J. W. (1984) Myelin-associated glycoprotein and myelinating Schwann cell-axon interaction in chronic B,B′-immunodipropinnitrile neuropathy.J. Cell Biol. 98, 1272–1278.

    PubMed  CAS  Google Scholar 

  • Trifilieff E., Luu B., Nussbaum J. L., Roussel G., Espinosa de los Monteros A., Sabatier J. M., and Van Rietschoten J. (1986) A specific immunological probe for the major myelin proteolipid: confirmation of a deletion in DM-20.FEBS Letters 198, 235–239.

    PubMed  CAS  Google Scholar 

  • Trifilieff E., Skalidis G., Helynck C., Lepage P., Sorokine O., Van Dorsselaer A., and Luu B. (1985) Structural data about the myelin proteolipid of apparent molecular weight 20 kdalton (DM-20).C. R. Acad. Sci. (III), 241–246.

    Google Scholar 

  • Turner R. S., Jen Chou C.-H., Mazzei G. J., Dembure P., and Kuo J. F. (1984) Phospholipid-sensitive calcium-dependent protein kinase preferentially phosphorylates serine-115 of bovine myelin basic protein.J. Neurochem. 43, 1257–1264.

    PubMed  CAS  Google Scholar 

  • Ulmer J. B. and Braun P. E. (1984) In vivo phosphorylation of myelin basic proteins in developing mouse brain: evidence that phosphorylation is an early event in myelin formation.Dev. Neurosci. 6, 345–355.

    CAS  Google Scholar 

  • Ulmer J. B. and Braun P. E. (1986a) In vivo phosphorylation of myelin basic proteins: age-related differences in32P incorporation.Dev. Biol. 117, 493–501.

    PubMed  CAS  Google Scholar 

  • Ulmer J. B. and Braun P. E. (1986b) In vivo phosphorylation of myelin basic proteins: single and double isotope incorporation in developmentally related myelin fractions.Dev. Biol. 117, 502–510.

    PubMed  CAS  Google Scholar 

  • Vartanian T., Szuchet S., Dawson G., and Campagnoni A. T. (1986) Oligodendrocyte adhesion activates protein kinase C-mediated phosphorylation of myelin basic protein.Science 234, 1395–1398.

    PubMed  CAS  Google Scholar 

  • Waehneldt T. V. (1975) Ontogenetic study of a myelin-derived fraction with 2′∶3′-cyclic nucleotide 3′-phosphohydrolase activity higher than that of myelin.Biochem. J. 151, 435–437.

    PubMed  CAS  Google Scholar 

  • Walravens P. and Chase H. P. (1969) Influence of thyroid hormone in formation of myelin lipids.J. Neurochem. 16, 1477–1484.

    PubMed  CAS  Google Scholar 

  • Webster H. deF., Palkovits C. G., Stoner G. L., Favilla J. T., Frail D. E., and Braun P. E. (1983) Myelin-associated glycoprotein: electron microscopic immunocytochemical localization in compact developing and adult central nervous system myelin.J. Neurochem. 41, 1469–1479.

    PubMed  CAS  Google Scholar 

  • Wernicke J. F. and Volpe J. J. (1986) Glial differentiation in dissociated cell cutures of neonatal rat brain: noncoordinate and density-dependent regulation of oligodendroglial enzymes.J. Neurosci. Res. 15, 39–47.

    PubMed  CAS  Google Scholar 

  • Wisniewski H. and Morell P. (1971)Quaking mouse: ultrastructural evidence for arrest of myelino-genesis.Brain Res. 29, 63–73.

    PubMed  CAS  Google Scholar 

  • Willard H. F. and Riordan J. R. (1985) Assignment of the gene for myelin proteolipid, protein to the X chromosome: implications for X-linked myelin disorders.Science 230, 940–942.

    PubMed  CAS  Google Scholar 

  • Wolf M. K. and Holden A. B. (1969) Tissue culture analysis of the inborn defect of CNS myelination injimpy mice.J. Neuropathol. Exp Neuro. 28, 195–213.

    CAS  Google Scholar 

  • Wolf M. K., Kardon G. B., Adcock L. H., and Billings-Gagliardi S. (1983) Hypomyelinated mutant mice. V. Relation betweenjp msd andjp reexamined on identical genetic backgrounds.Brain Res. 271, 121–129.

    PubMed  CAS  Google Scholar 

  • Wolf M. K., Schwing G. B., Adcock L. H., and Billings-Gagliardi S. (1981) Hypomyelinated mutant mice. III. Increased myelination in mutant cerebellum co-cultured with normal optic nerve.Brain Res. 206, 193–197.

    PubMed  CAS  Google Scholar 

  • Wolfgram F. (1966) A new proteolipid fraction of the nervous system—Isolation and amino acid analyses.J. Neurochem. 13, 461–470.

    PubMed  CAS  Google Scholar 

  • Wood P. and Bunge R. P. (1984) The biology of the oligodendrocyte,Oligodendroglia, Norton W. T., ed., Plenum, NY, pp 1–46.

    Google Scholar 

  • Wu N.-C. and Ahmad F. (1984) Calcium- and cyclic AMP-regulated protein kinases of bovine central nervous system.Biochem. J. 218, 923–932.

    PubMed  CAS  Google Scholar 

  • Yanagisawa K., Duncan I. D., Hamang J. P., and Quarles R. H. (1986) Myelin-deficient rat: analysis of myelin proteins.J. Neurochem. 47, 1901–1907.

    PubMed  CAS  Google Scholar 

  • Yanagisawa K. and Quarles R. H. (1986)Jimpy mice: quantitation of myelin-associated glycoprotein and other proteins.J. Neurochem. 47, 322–325.

    PubMed  CAS  Google Scholar 

  • Yim S. H., Szuchet S., and Polak P. E. (1986) Cultured oligodendrocytes: a role for cell-substratum interaction in phenotypic expression.J. Biol. Chem. 261, 11808–11815.

    PubMed  CAS  Google Scholar 

  • Yu Y.-T. and Campagnoni A. T. (1982) In vitro synthesis of the four mouse myelin basic proteins: evidence for the lack of a metabolic relationship.J. Neurochem. 39, 1559–1568.

    PubMed  CAS  Google Scholar 

  • Zeller N. K., Hunkeler M. J., Campagnoni A. T., Sprague J., and Lazzarini R. A. (1984) Characterization of mouse myelin basic protein messenger RNAs with a myelin basic protein cDNA clone.Proc. Natl. Acad. Sci. USA 81, 18–22.

    PubMed  CAS  Google Scholar 

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Campagnoni, A.T., Macklin, W.B. Cellular and molecular aspects of myelin protein gene expression. Mol Neurobiol 2, 41–89 (1988). https://doi.org/10.1007/BF02935632

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