Abstract
Thirty-two patients were entered into a double blind trial of antiemetic support in patients being treated with cisplatin. Patients were allocated to receive either oral nabilone (1 mg 8 hourly) or intravenous metoclopramide (1 mg kg−1 3 hourly) in random order over 4 courses. There was no difference between the two treatments in the overall incidence or severity of vomiting, although a subgroup of patients enjoyed a substantial reduction in episodes of vomiting whilst receiving metoclopramide. Side-effects were predictable from the pharmacology of the drugs.
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Crawford, S.M., Buckman, R. Nabilone and metoclopramide in the treatment of nausea and vomiting due to cisplatinum: A double blind study. Med. Oncol. & Tumor Pharmacother. 3, 39–42 (1986). https://doi.org/10.1007/BF02934575
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DOI: https://doi.org/10.1007/BF02934575