Summary
The importance of zinc in human health and disease has been reviewed by reporting data from the recent literature. The role of zinc in human nutrition, general health, skin diseases, acrodermatitis enteropathica, reproductive physiology and pathophysiology, pregnancy, non-insulin-dependent diabetes mellitus as well as atherosclerosis is discussed. The consequences of zinc deficiency and toxicity are also illustrated.
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References
Aggett P. J. A.: Zinc and pregnancy — Postgrad. Doct. Midd. East10, 10, 1987.
Appelbaum P. C., Shulman G., Chambers N. L., Simon N. V., Granados J. L., Fairbrother P. F., Naeye R. L.: Studies on the growth inhibitory properties of amniotic fluid from two United States population groups — Amer. J. Obstetr. Gynecol.147, 579, 1983.
Arquilla E., Packer S., Tarmas W., Miyamoto S.: The effect of zinc on insulin metabolism — Endocrinology103, 1440, 1978.
Arquilla E., Thiene P., Brugman T., Ruess W., Sugiyama R.: Effect of zinc on the conformation of antigenic determination of insulin — Biochem. J.175, 289, 1978.
Baer M. T., King J. C., Tamura T., Margen S.: Acne in zinc deficiency — Arch. Dermatol.114, 1093, 1978.
Battaglia F. C.: The comparative physiology of fetal nutrition — Amer. J. Obstetr. Gynecol.148, 850, 1984.
Bor N. M., Seyer V., Oner G., Ozhagaros K.: Zinc deficiency in erythema multiforme and treatment with zinc sulfate — Haccetepe Bull. Med. Surg. (Ankara)12, 51, 1979.
Brody M.: Treatment of chronic furunculosis with zinc — Lancetii, 1358, 1977.
Buamah P. K., Russel M., Bates G., Ward A. M., Skiller A. W.: Maternal zinc status: a determination of central nervous system malformation — Brit. J. Obstetr. Gynaecol.91, 788, 1984.
Cadar A. O., Babacau E., Arcasey A., Erten U.: Effects of nutrition on serum zinc concentration during pregnancy in Turkish women — Amer. J. clin. Nutr.33, 542, 1980.
Clayton B. E.: Clinical chemistry of trace elements — Advanc. clin. Chem.21, 147, 1980.
Daviss N. T.: Effect of phytic acid in mineral availability. In:Vahoung G. V., Kritchevsky D. (Eds): Dietary fibres in health and disease. Plenum Press, New York, 1982.
Ford L. C., Kashar W., Singer K. L., DeLange R. J., Lebhertz T. B., Alexander G.: Antibacterial activity of amniotic fluid β lysin and the influence of zinc ions — Brit. J. Obstetr. Gynaecol.89, 1, 1982.
Gordon E. F., Gordon R. C., Passal D. B.: Zinc metabolism: basic, clinical and behavioral aspects — J. Pediatr.99, 341, 1981.
Graves K., Kestanabaum T., Kalivas J.: Hereditary acrodermatitis enteropathica in an adult — Arch. Dermatol.116, 562, 1980.
Greenberg S. B. et al.: Inhibition ofChlamydia trachomatis growth in McCoy, HeLa and human prostate cells by zinc — Antimicrob. Agents Chemother.27, 1, 1985. Quoted in: Med. Digest 12, 41, 1986.
Hambidge K. M., Kres N. F., Jacobs M. A., Favies A., Guyette L., Ikle D. N.: Nutritional status during pregnancy, a longitudinal study — Amer. J. clin. Nutr.37, 429, 1983.
Hansson O.: Acrodermatitis enteropathica: report of two cases with a hypothesis concerning the pathogenesis of the disease — Acta derm.-venereol. (Stockh.)43, 465, 1963.
Ikeda M., Arata J., Isaka H.: Erosive pustular dermatosis of the scalp successfully treated with oral zinc sulphate — Brit. J. Dermatol.105, 742, 1980.
Indian Council of Medical Research Hyderabad: Annual Report, 1975; p. 117.
Jablonska S., Wolowa F.: Zinc sulphate and alopecia totalis — Brit. J. Dermatol.106, 485, 1981.
Jameson S.: Effect of zinc deficiency in human reproduction — Acta med. scand.192 (Suppl.), 89, 1976.
Kelsay J. L.: Effect of diet fibre on bowel function and trace mineral balance of human subjects — Cereal Chem.58, 2, 1981.
Kinlaw W. B., Levine A. S., Morley J. E., Silvis S. E., McClain C. J.: Abnormal zinc metabolism in type II diabetes mellitus — Amer. J. Med.75, 273, 1983.
Klevay L. M.: Diets deficient in copper and zinc — Med. Hypoth. (Engl. Edn)5, 1323, 1979.
Klevay L. M.: Interaction of copper and zinc in cardiovascular disease — Ann. N.Y. Acad. Sci.355, 140, 1980.
Krieger J. N., Reins M. F.: Zinc sensitivity inTrichomonas vaginalis: in vitro studies and clinical implications — J. infect. Dis.146, 341, 1982.
McMichael A. J., Dreasti I. E., Gibson G. I., Hartsborne J. M., Buckley R. A., Colley D. P.: Prospective study of maternal serum zinc levels and pregnancy outcome — Early human Develop.7, 59, 1982.
Meadows N. J., Smith M. F., Keeling P. W. N., Ruse W., Day T., Scopes J. W., Thompson R. P. H.: Zinc and small babies — Lancetii, 1135, 1981.
Michaelsson G.: Zinc therapy in acrodermatitis enteropathica — Acta derm.-venereol. (Stockh.)54, 377, 1974.
Michaelsson G.: Oral zinc in acne — Acta derm.-venereol. (Stockh.)60 (Suppl. 89), 87, 1980.
Mukherjee A. B., Sandstead H. H., Ratnaparkhi M. V., Johnson C. K., Milno B., Stolling H. P.: Maternal zinc, iron, folic acid and protein nutriture and outcome of human pregnancy — Amer. J. clin. Nutr.40, 496, 1984.
Orentreich N.: A clinical evaluation of two shampoos in the treatment of seborrheic dermatitis — J. Soc. cosmet. Chem.23, 189, 1972.
Prasad A. S.: Zinc deficiency in human subjects — Progr. clin. biol. Res.77, 165, 1981.
Prasad A. S., Oberleas D. (Eds): Trace elements in human health and disease. Academic Press, New York, 1976; vol. I and II.
Pryce-Smith D., Simpson R. I. D.: Taste of zinc — Lancetii, 1162, 1984. Quoted in: Midd. East Hlth 10, 49, 1986.
Sandstead H. H.: Zinc, copper and cholesterol — J. Amer. med. Ass.245, 1528, 1980.
Sandström B., Avidsson B., Lederblad A., Björn-Rasmussen E.: Zinc absorption from composition of meals. I. The significance of wheat extraction rate, zinc, calcium and protein content in meals based on bread — Amer. J. clin. Nutr.33, 739, 1980.
Savin J. A.: Skin diseases: the link with zinc — Brit. med. J.289, 1476, 1984.
Scane T. M., Hawkins D. F.: Antimicrobial activity in human amniotic fluid: relationship to zinc and phosphate — Brit. J. Obstetr. Gynaecol.91, 342, 1984.
Scott D. A., Fisher A. M.: The insulin and zinc content of normal and diabetic pancreas — J. clin. Invest.17, 725, 1938.
Shrank A.: Skin problems in infancy — Postgrad. Doct. Midd. East11, 46, 1987.
Simmer K., Thompson R. P. H.: Maternal zinc and intrauterine growth retardation — Clin. Sci.68, 395, 1985.
Solomon N. W.: On the assessment of zinc and copper nutriture in man — Amer. J. clin. Nutr.32, 856, 1979.
Solomon N. W.: Studies on the bioavailability of zinc in humans: effects of heme and non-heme iron on the absorption of zinc — Amer. J. clin. Nutr.34, 475, 1981.
Synder F. H., Buehler E. V., Winek C. L.: Safe evaluation of zinc 2-pyridinethiol-l-oxide in a shampoo formulation — Toxicol. appl. Pharmacol.7, 425, 1965.
Tuttle S., Aggett P. J. A., Campbell D., McGillivray I.: Zinc and copper nutrition in human pregnancy: a longitudinal study in normal primigravidae and primigravidae at risk of delivering a growth-retarded baby — Amer. J. clin. Nutr.41, 1032, 1985.
Weisman K.: Zinc metabolism and the skin. In:Rook A., Savin J. (Eds): Recent advances in dermatology. Churchill and Livingstone, Edinburgh, 1980; p. 109.
Weisman K., Wadskov S., Mikhelson H., Iknudsen L., Christenson K., Storgaard L.: Acquired zinc dermatosis in man — Arch. Dermatol.114, 1509, 1978.
Willmott F., Say J., Downey D., Hooklam A.: Zinc and recalcitrant trichomoniasis — Lanceti 1053, 1983.
Wolman S. L., Anderson G. H., Marliss E. D., Jeejeebhoy K. M.: Zinc in total parenteral nutrition: requirements and metabolic effects — Gastroenterology76, 458, 1979.
Zimmerman A. W., Dunham B. S., Nochimson D. J., Kaplam B. M., Clive J. M., Kunkel S. L.: Zinc transport in pregnancy — Amer. J. Obstetr. Gynecol.149, 523, 1984.
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Wahid, M.A., Fathi, S.A.H. & Aboul-Khair, M.R. Zinc in human health and disease. La Ricerca Clin. Lab. 18, 9–16 (1988). https://doi.org/10.1007/BF02918814
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DOI: https://doi.org/10.1007/BF02918814