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Effect of long-term nickel ingestion on insulin binding and antilipolytic response in rat adipocytes

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Abstract

Male Wistar rats of the third generation of rats drinking 200 μg Ni2+/mL as NiCl2 in their drinking water were studied. Basal plasma glucose and insulin levels were unchanged. Epididymal adipocytes from Ni2+-fed rats showed an increased insulin binding with a slight increase in apparent insulin affinity (ED50: Ni2+-fed rats 2.8×10−9 M and controls 5×10−9 M) with no change in insulin receptor numbers (Ni2+-fed rats 143,000±12,000 (6) receptors/cell and controls 126,000±13,000 (5)). Moreover, a decreased sensitivity to the antilipolytic response of insulin was also observed in adipocytes from Ni2+-fed rats. These events could represent actions of Ni2+ both at the receptor and post-receptor insulin levels. Several possible mechanisms involved in the process are suggested.

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Authors and Affiliations

  1. Department of Biochemistry, Faculty of Medicine and C.S.I.C., Faculty of Pharmacy, Complutense University, E-28040, Madrid, Spain

    Pilar Mayor, Rafael Cabrera, Bartolomé Ribas & Consuelo Calle

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  1. Pilar Mayor
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  2. Rafael Cabrera
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  3. Bartolomé Ribas
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  4. Consuelo Calle
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Mayor, P., Cabrera, R., Ribas, B. et al. Effect of long-term nickel ingestion on insulin binding and antilipolytic response in rat adipocytes. Biol Trace Elem Res 22, 63–70 (1989). https://doi.org/10.1007/BF02917417

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  • DOI: https://doi.org/10.1007/BF02917417

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