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Evaluation of zinc in the regulation of serum T3 and T4 levels and hepatic functions in carbontetrachloride-intoxicated rats

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Abstract

Circulating tri-iodothyronine (T3) and thyroxine (T4) concentrations were determined after 6 wk of zinc treatment to carbontetrachloride (CCl4) intoxicated male albino rats. Concentrations of T3 were observed to be significantly depressed following CCl4 treatment alone. On the contrary, no significant change was noticed in the concentrations of T4 when compared to controls. However, zinc administration to hepatotoxic animals resulted in restoring the T3 activity to within normal limits, thus indicating the indirect effects of zinc on the regulation of thyroid hormone concentrations. The activities of all the serum and hepatic marker enzymes were found to be significantly elevated following CCl4 treatment. However, following zinc supplementation to these intoxicated animals, the levels of the marker enzymes decreased significantly when compared to the CCl4-treated animals. A similar trend was seen in the case of lipid peroxidation following zinc treatment.

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References

  1. A. S. Prasad,Ann. Rev. Pharmacol. Toxicol. 20, 393 (1979).

    Article  Google Scholar 

  2. B. L. Vallee, W. E. C. Wacker, A. L. Barthalomay, and E. D. Robin,N. Engl. J. Med. 255, 403 (1956).

    PubMed  CAS  Google Scholar 

  3. M. Chvapil, J. N. Ryan, S. L. Elias and Y. M. Peng,Exp. Mol. Pathol. 19, 186 (1973).

    Article  PubMed  CAS  Google Scholar 

  4. T. F. Slater and B. C. Sawyer,Biochem. J. 123, 315 (1971).

    Google Scholar 

  5. A. Goel and D. Dhawan,Med. Sci. Res. 19, 113 (1991).

    Google Scholar 

  6. I. J. Chopra, D. H. Solomaon, G. W. Hepner and A. A. Morgestein,Ann. Int. Med. 90, 905 (1979).

    PubMed  CAS  Google Scholar 

  7. G. W. Hepner and I. J. Chopra,Arch. Int. Med. 189, 1117 (1979).

    Article  Google Scholar 

  8. I. J. Chopra, D. H. Solomon, U. Chopra, R. T. Young and G. N. Chuteco,J. Clin. Endocrin. Metab. 39, 501 (1974).

    CAS  Google Scholar 

  9. P. G. Walfish, H. Orrego, Y. Israel, J. Blake and H. Kalant,Ann. Int. Med. 91, 1 (1979).

    Google Scholar 

  10. S. M. Karandikar, G. V. Joglekar, G. K. Chitale and J. H. Balwani,Acta. Pharmacol. et Toxicol. 20, 274 (1963).

    CAS  Google Scholar 

  11. H. Anttinen, L. Ryhanen, U. Puistola, A. A. Arranto and A. Oikarinen,Gastroenterology 86, 532 (1984).

    PubMed  CAS  Google Scholar 

  12. I. D. P. Wooton, Microanalysis, in:Medical Biochemistry, E. J. Kings, ed., London, Churchill, p. 101 (1984).

    Google Scholar 

  13. S. Reitman and S. Frankel,Am. J. Clin. Pathol. 28, 56 (1957).

    PubMed  CAS  Google Scholar 

  14. T. C. Pederson, J. A. Buege and S. D. Aust,J. Biol. Chem.,248, 7134 (1973).

    PubMed  CAS  Google Scholar 

  15. O. H. Lowry, N. J. Rosebrough, A. L. Farr and R. F. Randall,Br. J. Biol. Chem. 193, 265 (1951).

    CAS  Google Scholar 

  16. C. J. McClean and J. Sule,Zinc deficiency in the alcoholic alcoholism (S. Winter, Ed.), Academic Press, NY, p. 5 (1983).

    Google Scholar 

  17. A. M. Kahn and R. S. Ozeran,Gastroenterology 53, 193 (1967).

    CAS  Google Scholar 

  18. R. E. Theirs and B. L. Vallee,J. Biol. Chem. 226, 911 (1957).

    Google Scholar 

  19. K. Melen, B. Hultberg, I. Haegerstrand, I. Isaksson, B. Joelsson, and S. Bengmark,Enzyme 33, 84 (1985).

    PubMed  CAS  Google Scholar 

  20. R. O. Recknagel,Pharmacol. Rev. 19, 145 (1967).

    PubMed  CAS  Google Scholar 

  21. H. Varley, in:Enzymes practical clinical Biochemistry, Delhi, Arnold Heinemann Publishers, p. 31 (1969).

    Google Scholar 

  22. T. Adzet, J. Camarasa and J. C. Laguna,J. Nat. Prod. 50, 612 (1987).

    Article  PubMed  CAS  Google Scholar 

  23. J. R. Hayes, L. W. Condie and J. F. Borzelleca,Fund. Appl. Toxicol. 7, 454 (1986).

    Article  CAS  Google Scholar 

  24. Y. Israel, P. G. Walfish, H. Orrego, J. Blake and H. Kalant,Gastroenterology 76, 116 (1979).

    PubMed  CAS  Google Scholar 

  25. I. J. Chopra,Endocrinology 101, 453 (1977).

    Article  PubMed  CAS  Google Scholar 

  26. S. Nomura, C. S. Pittman, T. B. Chambers, H. Hambers, M. W. Buck and T. Shimizu,J. Clin. Invest. 56, 643 (1975).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Biophysics, Panjab University, 160-014, Chandigarh, India

    A. Goel & D. Dhawan

  2. Department of Nuclear Medicine, Oswal Cancer Hospital, Ludhiana, India

    S. Kheruka

Authors
  1. A. Goel
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  2. D. Dhawan
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  3. S. Kheruka
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Goel, A., Dhawan, D. & Kheruka, S. Evaluation of zinc in the regulation of serum T3 and T4 levels and hepatic functions in carbontetrachloride-intoxicated rats. Biol Trace Elem Res 41, 59–68 (1994). https://doi.org/10.1007/BF02917217

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  • DOI: https://doi.org/10.1007/BF02917217

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