Summary
In light of the recent finding of the S-100 antigen in satellite cells of the rat adrenal medulla, we looked for S-100-labelled cells in both the normal human adrenal medulla and in pheochromocytomas. Immunostaining enabled us to detect S-100-labelled satellite cells by both light and electron microscopy in a significant number of pheochromocytomas and, as expected, in the normal human adrenal medulla.
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References
Bignami A, Dahl D (1977) Specificity of the glial fibrillary acidic protein for astroglia. J Histochem Cytochem 25: 466–469
Brown WJ, Barajas L, Waisman J, De Quattro V (1972) Ultrastructural and biochemical correlates of adrenal and extra-adrenal pheochromocytoma. Cancer 29: 744–759
Cervos-Navarro J, Bayer JM, Kaser H (1973) Ultrastrukturelle Differenzierung der Phaochromocytome. Virchows Arch [Pathol Anat] 361: 51–69
Cocchia D, Miani N (1980) Immunocytochemical localization of the brain-specific S-100 protein in the pituitary gland of adult rat. J Neurocytol. 9: 771–782
Cocchia D, Michetti F (1981) S-100 antigen in satellite cells of the adrenal medulla and the superior cervical ganglion of the rat. An immunochemical and immunocytochemical study. Cell Tissue Res 215: 103–112
Cocchia D, Michetti F, Donato R (1981) Immunochemical and immunocytochemical localization of S-100 antigen in normal human skin. Nature 294: 85–87
Coupland RE (1965) Electron microscopic observation on the structure of the rat adrenal medulla. II. Normal innervation. J Anat 99: 255–272
Dahl D, Chi NH, Miles LE, Nguyen BT, Bignami A (1982) Glial fibrillary acidic (GFA) protein in Schwann cells: fact or artifact. J Histochem Cytochem 30: 912–918
Edgar DB, Barde YA, Thoenen H (1979) Induction of fibre outgrowth and choline acetyltransferase in PC 12 pheochromocytoma cells by conditioned media from glial cells and organ extracts. Exp Cell Res 121: 353–361
Fujita T (1981) Paraneuron, its current implications. In: Kanno T (ed) Paraneurons, their features and function. Excerpta Medica, Amsterdam, pp 3–9
Grimelius L (1968) A silver stain for alfa2 cells in human pancreatic islets. Acta Soc Med Upsalien 73: 243–270
Ishikawa H, Nogami H, Shirasawa N (1983) Novel clonal strains from adul rat anterior pituitary producing S-100 protein. Nature 303: 711–713
Iwanaga T, Fujita T (1984) Sustentacular cells in the fetal human adrenal medulla are immunoreactive with antibodies to brain S-100 protein. Cell Tissue Res 236: 733–735
Kondo H, Iwanaga T, Nakajima T (1982) Immunocytochemical study on the localization of neuron-specific enolase and S-100 protein in the carotid body of rats. Cell Tissue Res 227: 291–295
Lauriola L, Michetti F, Stolfi VM, Tallini G, Cocchia D (1984a) Detection by S-100 immunolabelling of interdigitating reticulum cells in human thymomas. Virchows Arch [Cell Pathol] 45: 187–195
Lauriola L, Cocchia D, Sentinelli S, Maggiano N, Maira G, Michetti F (1984b) Immunohistochemical detection of folliculo-stellate cells in human pituitary adenomas. Virchows Arch [Cell Pathol] 47: 189–197
Lundberg JM, Hamberge B, Schultzberg M, Hokfelt T, Granberg PO, Efendic S, Terenius L, Goldstein M, Luft R (1979) Enkefalin- and somatostatin-like immunoreactivities in human adrenal medulla and pheochromocytoma. Proc Natl Acad Sci [USA] 76: 4079–4083
Michetti F, Dell’Anna E, Tiberio G, Cocchia D (1983) Immunochemical and immunocytochemical study of S-100 Protein in rat adipocytes. Brain Res 262: 352–356
Nakajima T, Yamaguchi H, Takahashi K (1980) S-100 protein in folliculostellate cells of the rat pituitary anterior lobe. Brain Res 191: 523–531
Pearse AGE (1976) Neurotransmission and the APUD concept. In: Coupland RE, Fujita T (eds) Chromaffin, enterochromaffin and related cells, Elsevier, Amsterdam, pp 147–154
Stefansson K, Wollman RL, Moore BW, Arnason BGW (1982a) S-100 protein in human chondrocytes. Nature 295: 63–64
Stefansson K, Wollman RL, Moore BW (1982b) Distribution of S-100 protein outside the central nervous system. Brain Res 234: 309–317
Sternberger LA, Hardy PH, Cuculis JJ, Mejer HG (1970) The unlabelled antibody enzym method of immunochemistry. Preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. J Histochem Cytochem 18: 315–333
Takahashi K, Yamaguchi H, Ishizechi J, Nakajima T, Nakazato Y (1981) Immunohistochemical and immunoelectron microscopic localization of S-100 protein in the interdigitating reticulum cells of the human lymph node. Virchows Arch [Cell Pathol] 37: 125–135
Unsicker K (1973) Fine structure and innervation of the avian adrenal gland. II. Cholinergic innervation of adrenal chromaffin cells. Z Zellforsch 145: 417–442
Unsicker K (1976) Chromaffin, small granule-containing and ganglion cells in the adrenal gland of reptiles. A comparative ultrastructural study. Cell Tissue Res 165: 477–508
Ziegler W, Hofmann HD, Unsicker K (1983) Rat adrenal non-chromaffin cells contain a neurite outgrowth-promoting factor immunologically different from nerve growth factor. Dev Brain Res 7: 353–357
Zomzely-Neurath CE, Walker WA (1980) Nervous system-specific proteins: 14-3-2 protein, neuron-specific enolase, and S-100 protein. In: Bradshaw RA, Schneider DM (eds) Proteins of the nervous system. Raven Press, New York, pp 1–57
Zuckerman JE, Herschman HR, Levine L (1970) Appearance of a brain-specific antigen (the S-100 protein) during human foetal development. J Neurochem 17: 247–251
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This work was supported partially by grant of the CNR-Progetto Finalizzato “Oncologia”
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Lauriola, L., Maggiano, N., Sentinelli, S. et al. Satellite cells in the normal human adrenal gland and in pheochromocytomas. Virchows Archiv B Cell Pathol 49, 13–21 (1985). https://doi.org/10.1007/BF02912081
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DOI: https://doi.org/10.1007/BF02912081