Summary
In the light of recent findings concerning the presence of S-100 antigen in folliculo-stellate cells of the rat adenohypophysis, we investigated the possible presence of S-100-labelled cells in both the normal human adenohypophysis and in pituitary adenomas. Immunostaining enabled us to detect, with both light and electron microscopy, the presence of S-100-labelled folliculo-stellate cells in a significant number of pituitary adenomas, mostly growth-hormone secreting, and, as expected, in the normal human adenohypophysis.
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Cocchia D, Miani N (1980) Immunocytochemical localization of the brain-specific S-100 protein in the pituitary gland of adult rat. J Neurocytol 9:771–782
Cocchia D, Michetti F, Donato R (1981) Immunochemical and immunocytochemical localization of S-100 antigen in normal human skin. Nature 294:85–87
Farquhar MG (1957) “Corticotrophs” of the rat adenohypophysis as revealed by electronmicroscopy. Anat Rec 127:291
Fukuda T (1973) Agranular stellate cells (so-called follicular cells) in human fetal and adult adenohypophysis and in pituitary adenoma. Virchows Arch [Pathol Anat] 359:19–30
Horvath E, Kovacs K, Penz G, Ezrin C (1974) Origin, possible function and fate of “follicular cells” in the anterior lobe of the human pituitary. Am J Pathol 77:199–212
Ishikawa H, Nogami H, Shirasawa N (1983) Novel clonal strains from adult rat anterior pituitary producing S-100 protein. Nature 303:711–713
Kagayama M (1965) The follicular cells in the pars distalis of the dog pituitary gland: an electron microscopic study. Endocrinology 77:1053–1060
Lauriola L, Michetti F, Stolfi VM, Tallini G, Cocchia D (1984) Detection by S-100 immunola- belling of interdigitating reticulum cells in human thymomas. Virchows Arch [Cell Pathol] 45:187–195
Michetti F, Dell’Anna E, Tiberio G, Cocchia D (1983) Immunochemical and immunocytochemical study of S-100 protein in rat adipocytes. Brain Res 262-352–356
Moore BW (1965) A soluble protein characteristic of the nervous system. Biochem Biophys Res Commun 19:739–744
Nakajima T, Yamaguchi H, Takahashi K (1980) S-100 protein in folliculo-stellate cells of the rat pituitary anterior lobe. Brain Res 191:523–531
Salazar H (1968) Ultrastructural evidence for the existence of a nonsecretory sustentacular cell in human adenohypophysis. Anat Rec 160:419–420
Shirasawa N, Kihara H, Yamaguchi S, Yoshimura F (1983) Pituitary folliculo-stellate cells immunostained with S-100 protein antiserum in postnatal, castrated and thyroidectomized rats. Cell Tissue Res 231:235–249
Stefansson K, Wollman RL, Moore BW, Arnason BGW (1982) S-100 protein in human chondrocytes. Nature 295:63–64
Sternberger LA, Hardy PhJr, Cuculis JJ, Meyer HG (1970) The unlabelled antibody enzyme method of immunochemistry. Preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes. J Histochem Cytochem 18:315–333
Takahashi K, Yamaguchi H, Ishizechi J, Nakajima T, Nakazato J (1981) Immunohistochemical and immunoelectron microscopic localization of S-100 protein in the interdigitating reticu- lum cells of the human lymph node. Virchows Arch [Cell Pathol] 37:125–235
Velasco ME, Roessmann U, Gambetti P (1982) The presence of glial fibrillary acidic protein in the human pituitary gland. J Neuropathol Exp Neurol 41:150–163
Yagishita S, Itoh Y, Nakazima S, Suzuki N, Hirata K, Yamashita T (1984) Folliculo-stellate cell adenoma of the pituitary. A light and electromicroscopic study. Acta Neuropathol [Berl] 62:340–344
Yoshimura F, Soji T, Sato S, Yokoyama M (1977) Development and differentiation of rat pituitary follicular cells under normal and some experimental conditions with special refer- ence to an interpretation of renewal cell system. Endocrinology 24:435–449
Zuckerman JE, Herschmann HR, Levine L (1970) Appearance of a brain-specific antigen (the S-100 protein) during human foetal development. J Neurochem 17:247–251
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Lauriola, L., Cocchia, D., Sentinelli, S. et al. Immunohistochemical detection of folliculo-stellate cells in human pituitary adenomas. Virchows Archiv B Cell Pathol 47, 189–197 (1984). https://doi.org/10.1007/BF02890202
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DOI: https://doi.org/10.1007/BF02890202