Summary
Although chronic progressive nephropathy and proteinuria are well-known to affect old laboratory rats, the occurrence of tubular metaplasia of Bowman’s capsule (TM) in aging rats has received little attention. We report here that old (24–26 months) male, but not female Sprague-Dawley rats show a high incidence of TM which is significantly (P<0.01) correlated with the levels of glomerular sclerosis and intracellular deposits of iron in the tubular epithelium. The incidence of these changes was not correlated with serum testosterone levels, which showed a significant age-related reduction in males. The reported findings suggest that the aging male Sprague-Dawley rat is a useful animal model to investigate the pathogenesis of TM and related morphologic changes in hematuric humans.
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References
Berg BN (1965) Spontaneous nephrosis with proteinuria, hyperglo-bulinemia and hypercholesterolemia in the rat. Proc Soc Exp Biol Med 119:417–420
Bolton W, Benton F, Maclay G, Sturgill B (1976) Spontaneous glomerular sclerosis in aging Sprague-Dawley rats. Am J Pathol 85:277–300
Brenner PF, Guerrero R, Cekan Z, Diczfalusy E (1973) Radioim-munoassay method for six steroids in human plasma. Steroids 22:775–794
Burek JD, Duprat P, Owen R, Peter CP, van Zwieten MJ (1988) Spontaneous renal disease in laboratory animals. Int Rev Exp Pathol 30:231–319
Kanel GC, Peters RL (1984) Glomerular tubular reflux. A morphological renal lesion associated with the hepatorenal syndrome. Hepatology 4:242–246
Luna LG, Ishak K (1967) A method for staining bile cannaliculi. Am J Med Techn 33:459–466
Nachman RL (1962) Metaplasia of parietal capsular epithelium of renal glomerulus. Arch Pathol 73:60–64
Owen RA, Heywood R (1986) Age-related variations in renal structure and function in Sprague-Dawley rats. Toxicol Pathol 14:158–167
Reidbord HE (1968) Metaplasia of the parietal layer of Bowman’s capsule. Am J Clin Pathol 50:240–242
Valdes AJ, Zhang J (1987) Intraglomerular tubular epithelial cells. Arch Pathol Lab Med 111:189–191
Ward AM (1970) Tubular metaplasia in Bowman’s capsule. J Clin Pathol 23:472–474
Zollinger HV, Mihatsch MJ (1978) Renal pathology in biopsy. Springer, New York, p 10
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Castelletto, L., Goya, R.G. Sex-related incidence of tubular metaplasia in Bowman’s capsule of aging rats. Virchows Archiv B Cell Pathol 59, 79–82 (1990). https://doi.org/10.1007/BF02899390
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DOI: https://doi.org/10.1007/BF02899390