Abstract
Polysaccharide fractions were prepared fromForsythia Corea by several different extraction schedules. The fractions obtained were designated as ForCo A, ForCo B and ForCo C respectively. ForCo C was further purified through Sephadex G 200 column chromatography and obtained two subfractions (Coreana A, Coreana B). ForCo C showed marked antitumor activity against sarcoma 180 and its activity was dose-dependent. Coreana A, purified from ForCo C, showed somewhat higher antitumor activity. ForCo C increased the number of circulating leucocytes and peritoneal exudate cells, but didn't show any significant effects on the phagocytic activity and total serum protein level. Chemical analysis showed that ForCo C was composed of glucose, galactose, xylose and arabinose. A close relationship between antitumor activities and polysaccharide contents was observed. These results indicate strongly that antitumor active principle ofForsythia Corea is polysaccharide.
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Moon, CK., Park, KS., Lee, SH. et al. Effects of antitumor polysaccharides fromForsythia Corea on the immune function (I). Arch. Pharm. Res. 8, 31–38 (1985). https://doi.org/10.1007/BF02897563
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DOI: https://doi.org/10.1007/BF02897563