Abstract
The analysis of biochemical parameters in 162 patients with various neoplastic disorders along with 50 normal subjects showed significant rise in serum alkaline phosphatase and lactate dehydrogenase as compared to normal subjects. 21 patients with other monoclonal gammopathies which include infection and immunological diseases were also studied. Parameters such as serum calcium, uric acid, total protein, albumin and globulin were also analyzed in 42 (26%) cases of multiple myeloma, 27 (17%) cases of gastro-intestinal malignancies, 22 (14%) cases of urogenital malignancies, 11 (6%) cases of carcinoma breast, 4 (2%) cases of bone tumors, 21 (12%) cases of other monoclonal gammopathies, including 7 (4%) cases of infection and 14 (8%) cases of immunological diseases. The results indicate use of enzymes alkaline phosphatase and lactate dehydrogenase in neoplastic disorders.
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Dimopoulos, M.A., Barlogie, B., Smith, T.L. and Alexanian, R. (1991) High serum lactate dehydrogenase level as a marker for drug resistance and short survival in multiple myeloma. Ann. Intern. Med. 115, 931–935.
Kornberg, A. and Polliack, A. (1980) Serum lactate dehydrogenase level in acute leukemia; marked elevations in lymphoblastic leukemia. Blood 56, 351–355.
Taylor, R.E., Duncan, W. and Horn, D.B. (1986) Lactate dehydrogenase as a marker for testicular germ cell tumors. Eur. J. Cancer. Clin. Oncol. 22, 647–653.
Schilling, R.F., McKnight, B., Crowley, J.J. (1982) Prognostic value of serum lactic dehydrogenase level in Hodgkins disease. J. Lab Clin. Med. 99, 382–387.
Chen, Y.H., Magalhaes, M.C. (1990) Hypoalbuminemia in patients with multiple myeloma. Arch. Intern. Med. 150, 605–610.
Levine, A.M. and Rosenberg, S.A. (1979) Alkaline phosphatase levels in osteosarcoma tissue are related to prognosis. Cancer 44, 2291–2293.
Singh, N.K., Gupta, R.M., Patra, H., Sharma, M. and Sanyal, B. (1984–85) Multiple myeloma: A Clinicopathological and Roentgenographic study of 44 cases. Indian J. Cancer 21, 184–187.
Putnam, F.W. and Udin, B. (1953) Proteins in multiple myeloma. I. Physiochemical study of serum proteins. Journal of Biological Chemistry. 202, 727–743.
Mundy, G.R., Bertolini, D.R. (1986) Bone destruction and hypercalcemia in plasma cell myeloma. Semin Oncol. 13, 291–299.
Cherng, N.C., Asal, N.R., Kuebler, J.P., Lee, E.T. and Solanki, D. (1991) Prognostic factors in multiple myeloma. Cancer 67, 3150–3155.
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Nigam, B., Joshi, S.P., Nagar, S. et al. Some biochemical markers in various neoplasms: A multivariate analysis. Indian J Clin Biochem 11, 124–128 (1996). https://doi.org/10.1007/BF02896429
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DOI: https://doi.org/10.1007/BF02896429