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Genomic alterations in low-grade, anaplastic astrocytomas and glioblastomas

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Pathology & Oncology Research

Abstract

To extend our understanding of potential stepwise genetic alterations that may underlie tumor progression from low-grade astrocytomas to glioblastomas, histopathologic and comparative genomic hybridization analyses were performed on tumor specimens from 68 primary lesions, including 40 glioblastomas, 10 anaplastic and 18 low-grade astrocytomas. The number of aberrations per case increased towards the higher grade tumors (grade II: 1.66±1.49; grade III: 2.80±1.68; grade IV: 3.02±1.07; F=6.955, p=0.002). A gain of 7/7q was common and the most frequently seen aberration in low-grade astrocytomas, whereas loss of 10q was the most frequently seen anomaly in anaplastic astrocytomas and glioblastomas. Chromosome 7p amplification was only detected in glioblastomas. Chromosome 10/10q deletion and combination of lp, 19q and 17p deletions were specific to high-grade astrocytic tumors. Sequences of chromosome 7 and 10 seem to have pivotal roles in the biology of human gliomas. The genomic copy deletions of chromosomes lp and 19q might provide an alternative mechanism in the genesis of astrocytomas.

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Authors and Affiliations

  1. Department of Neurosurgery, Osmangazi University, Eskisehir, Turkey

    Ali Arslantas MD, Ramazan Durmaz, Murat Vural, Erhan Cosan & Metin Ant Atasoy

  2. Department of Medical Genetics, Osmangazi University, Eskisehir, Turkey

    Sevilhan Artan, M. Hamza Müslümanoglu & Muhsin Özdemir

  3. Department of Pathology, Osmangazi University, Eskisehir, Turkey

    Ülkü Öner

  4. Department of Public Health, Medical Faculty, Osmangazi University, Eskisehir, Turkey

    Didem Arslantas

Authors
  1. Ali Arslantas MD
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  2. Sevilhan Artan
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  3. Ülkü Öner
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Correspondence to Ali Arslantas MD.

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Arslantas, A., Artan, S., Öner, Ü. et al. Genomic alterations in low-grade, anaplastic astrocytomas and glioblastomas. Pathol. Oncol. Res. 13, 39–46 (2007). https://doi.org/10.1007/BF02893439

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  • DOI: https://doi.org/10.1007/BF02893439

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