Summary
Experimental mice were immunized with cardiac myosin and complete Freund’s adjuvant (CFA) on days 0, 7 and 30 and control mice were immunized with CFA. Sera and myocardium samples were harvested on days 15, 21 and 120 after the first immunization. Pathological findings demonstrated that there were necrosis and inflammatory infiltration in acute stage and fibrosis mainly in chronic stage of experimental group. Anti-myosin antibodies were also found in sera of experimental mice, but not in control group. Our study showed that cardiac myosin served as an autoantigen to provoke autoimmunity and lead to the transformation of VMC into DCM.
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References
1996,12:1
Kodama M, Hanawa H, Saki Met al. Rat dilated cardiomyopathy after autoimmune giant cell myocarditis. Circ Res, 1994, 75(2):278
Neu N, Rose N R, Beisel K Wet al. Cardiac myosin induces myocarditis in genetically predisposed mice. J Immunol, 1987, 139:3630
Izumi T, Hanama H, Saeki Met al. Cardiac contractile proteins and autoimmune myocarditis. Mol Cell Biochem, 1993, 119:67
Gauntt C J, Higdon A L, Arizpe H Met al. Epitopes shared between coxsackievirus B3 and normal heart tissue contribute to CVB3-induced murine myocarditis. Clin Immunol Immunopathol, 1993, 68(2): 129
Cunningham M W, Antone S M, Gulizia J Met al. Cytotoxic and viral neutralizing antibodies crossreact with streptococcal M protein, enteroviruses, and human cardiacmyosin. Proc Natl Acad Sci USA, 1992, 89:1320
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Zhaohui, W., Yuhua, L., Jihua, D. et al. Myosin-induced autoimmune myocarditis in BALB/C mice. Current Medical Science 19, 112–114 (1999). https://doi.org/10.1007/BF02886889
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DOI: https://doi.org/10.1007/BF02886889