Abstract
60-year prion and scrapie research has led to a dilemma in understanding the unknown aetiology of the infectious neurodegenerative disorders with intriguing features. Current progress and dilemma in prion research are briefly but critically reviewed. Instead of providing a comprehensive coverage of the research history, attentions in this view are drawn toward both the major breakthrough in the advancement of protein-only hypothesis, and the puzzle why this hypothesis has not been fully accepted. In order to resolve the prion enigma in neuroscience, it is suggested that both technical and concept barriers remain to be crossed. Since prion research is a multi-interdisciplinary subject, this view is intended to both facilitate a better understanding of prion phenomenon by more scientists in natural science, and invite scientists outside the fields of molecular genetics and protein science for collaboration.
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References
Prusiner, S.B., Prions, Proc. Natl. Acad. Sci. USA, 1998, 95: 13363.
Aguzzi, A., Weissmann, C., Prion research: the next frontiers, Nature, 1997, 389: 795.
Chesebro, B., BSE and prions: uncertainties about the agent, Science, 1998, 279: 42.
Caughey, B., Chesebro, B., Prion protein and TSE, Trends Cell Biol., 1997, 7: 56.
Han, S.C., Tian, P.. Study on prion gene and protein structural biology, Chinese Science Bulletion (in Chinese), 1998, 43: 2017.
Voet, D., Voet, J.G., Biochemistry, 2nd ed., John Wiley & Son, Inc., 1995, 1023.
Yang, C. M., Prion radicals, a marriage between the big and the small, (Chemistry Online), 8. http://www.chemistrymag.org/col/1999/c99086.htm.
Gajdusek, D.C., Unconventional viruses and the origin and disappearance of Kuru, Science, 1977, 197: 943.
Griffith, J.S., Nature of the Scrapie Agent, Nature, 1967, 215: 1043.
Prusiner, S.B., Novel proteinaceous infectious particles cause scrapie, Science, 1982, 216: 136.
Jarrett, J.T., Lansbury, P.T., Jr., Seeding “one-dimensional crystallization” of amyloid: a pathogenic mechanism in Alzheimer’s disease and scrapie? Cell, 1993, 73: 1055.
Farquhar, CF., Somerville, R. A., Bruce, M.E., Straining the prion hypothesis, Nature, 1998, 391: 345.
Brandner, S., Raeber, A.. Sailer, A. et al., Normal host prion protein (PrPC) is required for scrapie spread within the central nervous system, Proc. Natl. Acad. Sci. USA, 1996, 93: 13148.
Manuelidis, L., Fritch, W., Infectivity and host response in Creutzfeldt-Jakob disease, Virology, 1996, 216: 46.
Lasmézas, C.I., Deslys, J.P., Robain, O. et al., Transmission of BSE agent to mice in the absence of detectable abnormal prion protein, Science, 1997, 275: 402.
Chesebro, B., Caughey, B., Scrapie agent replication without the prion protein? Curr. Biol., 1993, 3: 696.
Kimberlin, R.H., Reflections on the nature of scrapie agent, Trends in Biochem. Sci., 1982, 7: 392.
Silar, P., Daboussi, M. J., Non-conventional infectious elements in filamentous fungi, TIBTECH, 1999, 17: 141.
Prusiner, S.B., Scott, M.R., DeArmond, S.J. et al., Prion protein biology, Cell, 1998, 93: 337.
Carrell, R.W., Lomas, D.A., Conformational disease. The Lancet, 1997, 350: 134.
Hill, A.F., Desbruslais, M., Joiner, S. et al., The same strain causes vCJD and BSE, Nature, 1997, 389: 448.
Will, R.G., Cousens, S.N., Farrington, C.P. et al., Death from variant Creutzfeldt-Jakob disease, The Lancet, 1999, 353: 979.
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Yang, C., Chen, Y. “Protein-only” or “virino” in prion diseases?. Chin.Sci.Bull. 45, 285–288 (2000). https://doi.org/10.1007/BF02884692
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DOI: https://doi.org/10.1007/BF02884692