Abstract
The hypoglycemic effect of the aqueous extract ofAbroma augusta (Family: Steculiceae) was studied in normal as well as alloxan diabetic rats. Treatement of diabetic rats with 4 ml (4gm dry weight) of agueous extract ofA. augusta for 16 weeks resulted in gradual but significant fall in fasting blood glucose and improvement in glucose tolerance. Serum total and LDL cholesterol and triacylglycerol which increased in diabetic rats showed improvement. These results show that the water extract ofA. augusta has both hypoglycemic and hypocholesterolemic effects.
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References
David, M.N. 1996. The pathophysiology of diabetic complications: How much does the glucose hypothesis explain? Ann. Intem. Med. 174(I pt2), 86–89.
American Diabetic Association (1998). Screening for Type II diabetes. Diabetes care. 21(1), S20-S31.
Bajaj, J. S. and Madan, R. (1993). Diabetes in tropics and developing countries. IDF Bull. 38(2), 5–6.
Mayes, W. Jr. (1993) Fighting a global epidemic with simple weapons. IDF Bulletin. 38(2), 4.
World Health Organization. (1994) Prevention of diabetes mellitus. Technical Report Series. No.844, WHO. Geneva.
Shukia, R., Sharma, S.B., Puri, D., Prabhu, K.M. and Murthy, P.S. (2000) Medicinal plants for treatment of diabetes mellitus. Ind. J. Clin. Biochem. 15 (August, Suppl.), 169–177.
Thakur, R.S., Puri, H.S. and Husin, A. (1989) Abroma augusta (L) L.f. In: Major Medicinal Plants of India. Published by Central Institute of Medicinal and Aromatic Plants, Lucknow, India. p. 4–6.
Srivastava, G.P. and Basu, N.K. (1956) Studies onAbroma augusta Linn. PartI. Chemical examination. Ind. J. Pharmacy 18, 472–475.
Adityachaudhury, N. and Gupta, P.K. (1969) Chemical examination ofAbroma augusta. J. Ind. Chem. Soc. 46(9), 849–850.
Pakrashi, A., Basak, B. and Mookerji, N. (1975) Search for antifertility agents from Indigenous medicinal plants. Ind. J. Med. Res. 63(3), 378–381.
Pugazhenthi, S. and Murthy, P.S. (1989) Studies on isolation and effect of three orally active hypoglycemic priciples Kakara Ib, IIIa and IIIb from bitter gourd. Diabetes Bulllletin 9, 73–76.
Puri, D., Prabhu, K.M. and Murthy, P.S. (1994) Hypocholesterolemic effect of the hypoglycemic principle of fenugreek (Trigonella foenum graecum) Ind. J. Clin. Biochem. 9, 13–16.
Shukla, R., Anand, K., Prabhu, K.M. and Murthy, P.S. (1995). Hypocholesterolemic effect of water extract of the bark of banyan tree (Ficus bengalensis) in alloxan recovered, mildly diabetic and severely diabetic rabbits, Int. J. Diab. 14, 78–81.
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Eshrat, H., Hussain, M.A., Jamil, K. et al. Preliminary studies on the hypoglycaemic effect ofAbroma augusta in alloxan diabetic rats. Indian J Clin Biochem 16, 77–80 (2001). https://doi.org/10.1007/BF02867572
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DOI: https://doi.org/10.1007/BF02867572