Summary
The safety of Chuangyuling (CYL) dressing—a multifunctional medicine carrying biomaterial was evaluated in order to provide foundation for the application of CYL as material used in the wound healing. The traditional Chinese medicine (TCM) extract solution was compounded with scaffolds (gelatin and Bletilla hyacinthine gum), and then frozen and dried to form spongy and porous material CYL. According to the standard of biological evaluation of medical devices that was instituted by the ministry of health of China[1], the biological evaluation of CYL dressing was conducted. The results showed that all the contents of biological evaluation test consisting of acute toxicity, skin irritation, sensitization and cytotoxicity met the requirement of standards. It was concluded that the biomaterial carrying TCM (CYL dressing) is safe for application of wound healing.
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References
Hao H P. Biological evaluateion of medical devices (Chinese). Beijing: The standard publishing House of China, 2000, 285–295, 334–347
Zheng X P. The latest research of Chinese Herb accelerating the wound healing. J Tradi Chin Med Treatin vitro (Chinese) 2000, 9:800
Chen Q. Methodology of Chinese Herbal Pharmaceutical Research (Chinese). Beijing: People's Health Press, 1993, 744
Mosmann T. Rapid clorimetric assay for cellular growth and survival: application to proliferation and cytotoxic assays. J Immunol Meth, 1983,65:5563
Smith P K, Krohn R L, Hermanson A Ket al. Measurement of protein using bicinchnic acid. Anal Bioch, 1985,150,76
Yannas I V, Burke J F. Design of an artificial skin. I: Basic design principles. J Biomed Mater Res, 1980,14: 65
Oliver R F, Barker H, Cooke A. Dermal collagen implants. Biomaterials, 1982,3:38
Suzuki S, Matsuda K, Isshi Net al. Clinical evaluation of a new bilayer “artificial skin” composed of collagen sponge and silicone layer. British J Plastic Surgery, 1990, 43:47
Kirkpatrick C J, Bittinger F, Wagner Met al. Current trends in biocompatibility testing. Proc Inst Mech English, 1998,212(2):75
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PENG Rui, male, born in 1967, Associate Professor
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Rui, P., Qixin, Z., Jie, H. et al. Biological evaluation of chuangYuLing dressing—A multifunctional medicine carrying biomaterial. Current Medical Science 25, 72–74 (2005). https://doi.org/10.1007/BF02831391
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DOI: https://doi.org/10.1007/BF02831391