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Role of hepatocyte growth factor and its receptorc-met in multiple myeloma

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Abstract

Multiple myeloma is characterised by the clonal expansion of malignant plasma cells. Recently, we reported that a new cytokine, hepatocyte growth factor (HGF), and its receptorc-met are related to this disease. Here we review the observations that associate HGF with myeloma. Malignant plasma cells produce HGF and express the receptorc-met. Many patients have elevated HGF levels, which is unfavourable both in terms of survival and response to treatment. Possible biological roles of HGF in this disease are discussed, with special focus on bone homeostasis and its binding to heparan sulphate proteoglycans.

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Authors and Affiliations

  1. The Institute of Cancer Research and Molecular Biology, Norwegian University of Science and Technology, Medisinsk-Teknisk Senter, N-7005, Trondheim, Norway

    Carina Seidel MD, Magne Børset, Henrik Hjorth-Hansen & Anders Sundan

  2. Section of Hematology, University Hospital, Norwegian University of Science and Technology, Trondheim, Norway

    Anders Waage

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  1. Carina Seidel MD
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  2. Magne Børset
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  3. Henrik Hjorth-Hansen
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  4. Anders Sundan
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  5. Anders Waage
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Seidel, C., Børset, M., Hjorth-Hansen, H. et al. Role of hepatocyte growth factor and its receptorc-met in multiple myeloma. Med Oncol 15, 145–153 (1998). https://doi.org/10.1007/BF02821933

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