Abstract
Eleven substituted tricyclic quinazolines and their synthetic precursors were tested for antibacterial effects. 3-Chloromethylcarbonyl-2-methylquinazolin-4-thione and 5-phenyl-2,3-dihydro-1,2,4-triazolo[4,3-c]quinazolin-3-one had the highest antibacterial effect againstBacillus subtilis, the MIC values being 50 mg/L. Two tested derivatives were more active againstPseudomonas aeruginosa than ampicillin, the IC50 values being 80 and 100 mg/L. The most effective derivatives contained in the structure generally pharmacologically active chromophores—methyl group in position 2 and a chloromethyl configuration on the carbonyl group in position 3.
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Jantová, S., Špirková, K., Stankovský, Ŝ. et al. Antibacterial effect of some substituted tricyclic quinazolines and their synthetic precursors. Folia Microbiol 44, 187–190 (1999). https://doi.org/10.1007/BF02816240
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DOI: https://doi.org/10.1007/BF02816240