Abstract
GTPase-activating protein is known to regulate the conversion between ras-GTP and ras-GDP. We studied the basal expression of GTPase-activating protein-like immunoreactivity in mouse cerebral regions using a polyclonal anti-GTPase-activating protein antibody. Cells with GTPase-activating protein-like immunoreactivity were distributed in frontal cortical layers IV and V, and in the parietal cortex, piriform cortex, amygdaloid area, septum, lateral thalamus, and hypothalamus. The GTPase-activating protein-like immunoreactivity was also observed in fiber-like structures in the caudate putamen, stria terminalis, internal capsule, and medial forebrain bundle, and around CA2 pyramidal cells in Ammon’s horn. These results imply that GTPase-activating protein is constitutively expressed in mouse brain regions and may have physiological functions in specific neuronal pathways in the brain.
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Namima, M., Takeuchi, K., Watanabe, Y. et al. Localization of GTPase-activating protein-(GAP) like immunoreactivity in mouse cerebral regions. Molecular and Chemical Neuropathology 35, 157–172 (1998). https://doi.org/10.1007/BF02815122
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DOI: https://doi.org/10.1007/BF02815122