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Immunomodulators isolated from microorganisms

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Abstract

Microbial products are surveyed that have an immunoregulatory activity, both from the realm of low-molar-mass compounds and from the group of naturally occurring polymers. The data include in most cases the producer organism or source, a brief chemical characteristic and biological activity. Various groups of substances are compared, the drawbacks attendant on their acquisition and application are pointed out and their advantageous properties are specified.

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Abbreviations

AbFC:

antibody-forming cells

ADCC:

antibody-dependent cell mediated cytotoxicity

BCGF:

B-cell growth factor

DOPA:

3,4-dihydroxyphenylalanine

DTH:

delayed-type hypersensitivity

ELISA:

enzyme-linked immunosorbent assay

GvHR:

graft-vs.-host reaction

HIV:

human immunodeficiency virus

Ig:

immunoglobulin

IFN:

interferon

IL-1, IL-2, IL-3:

interleukins 1, 2 and 3

LPS:

lipopolysaccharide

MDP:

muramyl dipeptide

MΦ:

macrophages

NCWS:

Nocardia-cell wall skeleton

NDCM:

Nocardia-delipidated cell mitogen

NK:

natural killers

NWSM:

Nocardia water-soluble mitogen

NWSMP:

Nocardia water-soluble pellet

PWM:

pokeweed mitogen

SRBC:

sheep red blood cells

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  1. Institute of Microbiology, Czechoslovak Academy of Sciences, 142 20, Prague 4

    Z. Vaněk, J. Matějů & E. Čurdová

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  1. Z. Vaněk
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  2. J. Matějů
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  3. E. Čurdová
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Translated by K. Sigler

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Vaněk, Z., Matějů, J. & Čurdová, E. Immunomodulators isolated from microorganisms. Folia Microbiol 36, 99–111 (1991). https://doi.org/10.1007/BF02814487

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