Abstract
Lincomycin biotransformation was conducted by usingStreptomyces venezuelae andStreptomyces phaeochromogenes cell-free extracts. Reaction products were isolated and identified by MS and NMR spectroscopy as lincomycin sulfoxide and lincomycin sulfone. Both compounds arise also by chemical oxidation with hydrogen peroxide; this reaction represents a new efficient way for the preparation of lincomycin sulfoxide and lincomycin sulfone and simultaneously excludes the biotransformation of lincomycin using haloperoxidases.
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Posíšil, S., Sedmera, P., Halada, P. et al. Oxidation of lincomycin by hydrogen peroxide restricts its potential biotransformation with haloperoxidases. Folia Microbiol 46, 376–378 (2001). https://doi.org/10.1007/BF02814424
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DOI: https://doi.org/10.1007/BF02814424