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Production of cytochalasins C, D & E from dematiaceous hyphomycetes

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Abstract

One hundred isolates of 27 species belonging to 13 genera of dematiaceous hyphomycetes were screened for production of cytochalasins C, D and E. Only two isolates ofBipolaris neergaardii and one isolate ofPhoma herbarum produced cytochalasins C and D. Also, cytochalasin E was produced by two isolates ofAlternaria chlamydospora, and one isolate ofCochliobolus tuberculatus. This is the first report about the production of cytochalasins C, D and E by these species of dematiaceous hyphomycetes.

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References

  • Aldridge D.C., Turner W.B.: The identity of zygosporin A and cytochalasin D.J. Antibiot. 22, 170 (1969).

    PubMed  CAS  Google Scholar 

  • Aldridge D.C., Burrows B.F., Turner W.B.: The structure of the fungal metabolites cytochalasin E and F.J. Chem. Soc. Chem. Commun. 3, 148 (1972).

    Article  Google Scholar 

  • Bottalico A., Capasso R., Evidente A., Randazzo G., Vurro M.: Cytochalasins: Structure-activity relationships.Phytochemistry 29, 93–96 (1990).

    Article  CAS  Google Scholar 

  • Carter S.B.: Effects of cytochalasins on mammalian cells.Nature 213, 261–264 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Di Menna M.E., Mortimer P.H., White E.P.: The genusPhoma, pp. 105–106 inMycotoxic Fungi, Mycotoxins, Mycotoxicoses. An Encyclopedic Handbook, Volume I. Mycotoxic Fungi and Chemistry of Mycotoxins (T.D. Wyllie, L.G. Morehouse, Eds). Marcel Dekker, New York-Basel 1977.

    Google Scholar 

  • Minato H., Matsumoto M.: Studies on the metabolites ofZygosporium masonii. I. Structure of zygosporin A.J. Chem. Soc. C 38–45 (1970).

    Google Scholar 

  • Natori S.: Toxic cytochalasins, pp. 559–581 inMycotoxins in Human and Animal Health (J.V. Rodricks, C.W. Hesseltine, M.A. Mehlman, Eds). Pathotox, Park Forest South (Illinois) 1977.

    Google Scholar 

  • Rothweiler W., Tamm C.H.: Isolation and structure of phomin.Experientia 22, 750–752 (1966).

    Article  CAS  Google Scholar 

  • Sam C.T.: Effect of nutrient variations on growth and brefeldin A formation inCurvularia lunata.Folia Microbiol. 22, 43–46 (1977).

    Article  CAS  Google Scholar 

  • Scott P.M., Harwig J., Chen Y.K., Kennedy B.P.C.: Cytochalasins A and B from strains ofPhoma exigua var.exigua and formation of cytochalasin B in potato gangrene.J. Gen. Microbiol. 87, 177–180 (1975).

    PubMed  CAS  Google Scholar 

  • Thilly W.G., Liber H.L., Wogan G.N., p. 53 inCytochalasins, Biomedical and Cell Biological Aspect (S.W. Tanenbaum, Ed.) Elsevier/North-Holland Biomedical Press, Amsterdam 1978.

    Google Scholar 

  • Turner W.B., Aldridge D.C., p. 459 inFungal Metabolites II. Academic Press, London 1983.

    Google Scholar 

  • Wyss R., Tamm C., Verdas J.C.: Differential hydrogen exchange during biosynthesis of cytochalasin B and cytochalasin D.Helv. Chim. Acta 63, 1538–1541 (1980).

    Article  CAS  Google Scholar 

  • Zohri A.A., Sabah Saber M.: New sources of cytochalasins A and B from dematiaceous hyphomycetes.Lett. Appl. Microbiol. 19, 37–39 (1994).

    PubMed  CAS  Google Scholar 

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El-Kady, I.A., Mostafa, M.E. Production of cytochalasins C, D & E from dematiaceous hyphomycetes. Folia Microbiol 40, 301–303 (1995). https://doi.org/10.1007/BF02814213

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  • DOI: https://doi.org/10.1007/BF02814213

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