Summary
The effect of autonomic denervation on the exocrine pancreatic secretion and blood flow was studied in a group of dogs. Pancreatic secretion was collected and analyzed for volume and bicarbonate by direct cannulation of the main papilla through a duodenotomy prior to and following truncal vagotomy and celiac plexus denervation.
Pancreatic blood flow was determined by the radioisotope distribution method (141Ce). Truncal vagotomy causes a reduction in pancreatic secretion of volume and bicarbonate by 25–30%, while celiac denervation caused a reduction of 70% in the secretion. The mean baseline pancreatic blood flow was 0.5 ml/g pancreas/min. Truncal vagotomy did not cause any significant flow changes, while celiac denervation caused a significant increase in blood flow of 350% (to 1.75 ml/g/min). These results suggest that both the parasympathetic and the sympathetic system affect pancreatic secretion independently of their effect upon pancreatic blood flow.
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References
Singh, M. and Webster, P.D., Neurohormonal control of pancreatic secretion, Gastroenterology, 1978; 74: 294–309.
Magee, D.F., A consideration of the cholinergic nerve supply to the pancreas, Mount Sinai J. Med., 1982; 49: 94–101.
Konturek, S.J., Radecki, T., Biernat, J. and Thor, P., Effect of vagotomy on pancreatic secretion evoked by endogenous and exogenous cholecystokinin and caerulein, Gastroenterology, 1972; 63: 273–278.
Lenninger, S.G., Magee, D.F. and White, T.T., Effect of gastric, extragastric and truncal vagotomy on the external secretion of the pancreas in the dog, Ann. Surg., 1965; 162: 1057–1062.
Demol, P. and Sarles, H., Action of catecholamines on exocrine pancreatic secretion of conscious rats, Arch. Int. Pharmacodyn., 1980; 243: 149–163.
Suda, Y., Robinson, I. and White, T.T., The effects of adrenergic blocking agents on pancreatic secretion in dogs, Ann. Surg., 1969; 169: 625–630.
Vaysse, N., Bastie, M.J., Pascal, J.P., Martinel, C., Fourtanier, G. and Ribet, A., Effect of catecholamines and their inhibitors on the isolated canine pancreas, Part 1 (Noradrenaline and isoprenoline), Gastroenterology, 1977; 72: 711–718.
Kaplan, M.H., Stress, pancreatic perfusion and acute pancreatitis: A unified concept of pathogenesis, Mount Sinai J. Med., 1985; 52: 326–330.
Sapirstcin, L.A., Regional blood flow by fractional distribution of indicators, Am. J. Physiol., 1958; 193; 161.
Delaney, J.P. and Grim, E., Influence of hormones and drugs on canine pancreatic blood flow, Am. J. Physiol. 1966; 211: 1398.
Thambugala, R.L. and Baron, J.H., Pancreatic secretion after selective and truncal vagotomy in the dog, Br. J. Surg., 1971; 58: 839–844.
Dreiling, D.A., Druckerman, L.J. and Hollander, F., The effect of complete vagisection and vagal stimulation on pancreatic secretion in man, Gastroenterology, 1952; 20: 578–586.
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Klein, E., Salinas, A., Shemesh, E. et al. Effects of autonomic denervation on canine exocrine pancreatic secretion and blood flow. Int J Pancreatol 3, 165–170 (1988). https://doi.org/10.1007/BF02798928
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DOI: https://doi.org/10.1007/BF02798928