Abstract
In a supplementation study in which organic selenium asl-selenomethionine was administered in low doses during 1 yr, alterations in the concentrations of metal ions in the erythrocytes and the neutrophil granulocytes were observed. In the erythrocytes, altered concentrations of zinc were parallel with selenium. The concentrations of magnesium, calcium, manganese, copper, and sulfur were not significantly altered. However, altered concentrations of iron and zinc were observed in the neutrophils. The concentrations of magnesium, calcium, manganese, copper, and sulfur were not significantly altered.
The accumulation of selenium in individual blood cells was different from that obtained with supplementation of inorganic selenium. When organic selenium was supplemented, the thrombocytes accumulated more selenium than the erythrocytes and the neutrophil granulocytes.
The observations indicate that selenium interacts with metal ions at the cellular level when supplemented in low doses. The chemical form of selenium might be important in nutrition and therapy in view of the interaction and distribution pattern at the cellular level.
Similar content being viewed by others
References
Keshan Disease Research Group of the Chinese Academy of Medical Science, Beijing,Chinese Med. J. 92, 471 (1979).
Keshan Disease Research Group of the Chinese Academy of Medical Science, Beijing,Chinese Med. J. 92, 477 (1979).
J. Li, D. Chen, and S. Ren,Huangjing Kexue 2, 338 (1981).
E. Johansson and U. Lindh,Proceedings of Trace Elements for Man and Animal (TEMA 5), Aberdeen 1985, p. 598.
U. Lindh and E. Johansson,Neurotoxicology 4, 3, 177, (1983),
E. Johansson, U. Lindh, and E. Landström,Biol. Trace Elem. Res. 5, 433, (1983).
E. Johansson and U. Lindh,Nutr. Res. Suppl. 1, 156 (1985).
U. Lindh, E. Johansson, and L. Gille,Nucl. Instr. Meth. B3, 631 (1984).
U. Lindh,Anal. Chim. Acta. 150, 233, (1983).
U. Lindh and T. Sunde,Nucl. Instr. Meth. B10/11, 703 (1985).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Johansson, E., Lindh, U. Interactions of selenium with metal ions at the cellular level. Biol Trace Elem Res 12, 101–108 (1987). https://doi.org/10.1007/BF02796668
Issue Date:
DOI: https://doi.org/10.1007/BF02796668