Abstract
The purpose of this study was to determine if diet or various metabolites alter chromium (Cr) uptake and distribution in rats. Radioactively labeled Cr was detected within 15 min of oral administration to rats, and the total amount retained remained relatively constant from 1 to 24 h. Dietary Cr intake did not alter Cr retention or distribution. The majority of the Cr was retained in the carcass. However, when the amount of labeled Cr was expressed per gram of tissue, the highest amounts of Cr were found in the kidneys, spleen, and pancreas. Pharmacological doses of insulin, epinephrine, glucagon, and dibutyryladenosine-3’ −5’ cyclic monophosphate, prostaglandins A1, A2, B1, B2, E1, E2, F1α, and F2α did not significantly influence Cr retention. Glucose, sucrose, nicotinic acid, glutathione, and other metabolites administered orally in conjunction with labeled Cr also did not significantly alter Cr retention. These data indicate that most nutrients and metabolites do not alter Cr retention and distribution. The regulation of Cr homeostasis appears to be at the level of excretion.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
K. N. Jeejeebhoy, R. C. Chu, E. B. Marliss, G. R. Greenberg, and A. Bruce-Robertson,Am. J. Clin. Nutr. 30, 531 (1977).
H. Freund, S. Atamian, and J. E. Fischer,J. Am. Med. Assoc. 241, 496 (1979).
R. O. Brown, S. Lynn-Forloines, R. E. Cross, and W. D. Heizer,Dig. Dis. Sci. 31, 661 (1986).
R. A. Anderson,Sci. Total Environ. 86, 75 (1989).
R. A. Anderson, inEssential and Toxic Trace Elements in Human Health and Disease, Wiley Liss, New York, pp. 221–234 (1993).
R. A. Anderson and A. S. Kozlovsky,Am. J. Clin. Nutr. 41, 1177 (1985).
R. J. Doisy, D. H. P. Streeten, J. M. Freiberg, and A. J. Schneider, inTrace Elements in Human Health and Disease, Essential and Toxic Elements, Academic, New York, pp. 79–104 (1976).
R. A. Anderson, N. A. Bryden, K. Y. Patterson, C. Veillon, M. B. Andon, and P. B. Moser-Veillon,Am. J. Clin. Nutr. 57, 519 (1993).
N. S. C. Chen, A. Tsai, and I. A. Dyer,J. Nutr. 103, 1182 (1973).
H. J. Dowling, E. G. Offenbacher, and X. Pi-Sunyer,Nutr. Res. 10, 1251 (1990).
S. Wallach and L. Verch,J. Am. Coll. Nutr. 5, 291 (1986).
M. K. Song and N. F. Adhan,Fed. Proc. 36, 1138 (1977).
C. J. Hahn and G. W. Evans,Am. J. Physiol. 228, 1020 (1975).
M. M. Polansky and R. A. Anderson,Lab. Anim. Sci. 29, 357 (1979).
W. W. Campbell, M. M. Polansky, N. A. Bryden, J. H. Soares, Jr., and R. A. Anderson,J. Nutr. 119, 653 (1989).
R. A. Anderson, N. A. Bryden, and M. M. Polansky,Biol. Trace Element Res. 32, 117 (1992).
L. L. Hopkins, Jr.Am. J. Physiol. 209, 731 (1965).
W. Mertz, E. E. Roginski, and R. C. Reba,Am. J. Physiol. 209, 489 (1965).
R. Jain, R. L. Verch, S. Wallach, and R. A. Peabody,Am. J. Clin. Nutr. 34, 2199 (1981).
C. Onkelinz,Am. J. Physiol. Endocrinol. Metab. Gastrointest. Physiol. 1, E478 (1977).
W. J. Visek, I. B. Whitney, U. S. G. Kuhn, III, and C. L. Comar,Proc. Soc. Exp. Biol. Med. 84, 610 (1953).
D. Oberleas, Y.-C. Li, B. J. Stoecker, S. A. Henley, K. S. Keim, and J. C. Smith, Jr.Nutr. Res. 10, 1189 (1990).
J. L. Kraszeski, S. Wallach, and R. L. Verch,Endocrinology 104, 881 (1979).
M. L. Lifschitz, S. Wallach, R. A. Peabody, R. L. Verch, and R. Agrawal,Am. J. Clin. Nutr. 33, 57 (1980).
K. S. Keim, C. L. Holloway, and M. Helsted,Cereal Chem. 64, 352 (1987).
C. D. Seaborn and B. J. Stoecker,Nutr. Res. 10, 1401 (1990).
L. L. Hopkins, Jr. and K. Schwarz,Biochem. Biophys. Acta 90, 484 (1964).
C. H. Hill, inTrace Elements and Human Disease, Academic, New York, pp. 281–300 (1975).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Anderson, R.A., Polansky, M.M. Dietary and metabolite effects on trivalent chromium retention and distribution in rats. Biol Trace Elem Res 50, 97–108 (1995). https://doi.org/10.1007/BF02789412
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02789412