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In vitro assessment of the toxicity of metal compounds

I. Mammalian Cell transformation

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Abstract

A review of the activity of metal compounds in mammalian cell transformation assays has been completed. Results from these assays appear to correlate well with the known carcinogenic activity displayed by specific metal compounds in vivo. Studies of cell transformation in vitro may provide information pertaining to the mechanism of the induction of carcinogenesis by certain metals.

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Authors and Affiliations

  1. Division of Toxicology, Department of Pharmacology, The University of Texas Medical School at Houston, PO Box 20708, 77025, Houston, Texas

    J. Daniel Heck & Max Costa

Authors
  1. J. Daniel Heck
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  2. Max Costa
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Daniel Heck, J., Costa, M. In vitro assessment of the toxicity of metal compounds. Biol Trace Elem Res 4, 71–82 (1982). https://doi.org/10.1007/BF02783248

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