Abstract
Blackfoot disease is a peripheral vascular disease resulting in gangrene of the lower extremities. Though extensive epidemiological study has implicated that high arsenic content in artesian well water of the endemic area, bears some important connection with the disease, the etiology of the disease is still unknown. In this study, attention is paid to multielement determination in order to find out whether the trace elements in hair of Blackfoot disease patients are different from those of the controls.
Experimental results indicate that the concentrations of As and Se in hair of patients are significantly higher than those of the controls, but Ca and Zn are significantly lower than those of the controls. The possible connection of these elements with the etiology of the disease is discussed.
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References
K. M. Chen and H. Y. Wu,J. Formosan Med. Assoc. 61, 611 (1962).
S. Yeh,Human Pathol. 4, 469 (1973).
E. Astolif et al.,Biol. Trace Element Res. 3, 131 (1981).
H. S. Yu, H. M. Sheu, S. S. Ko, L. C. Chiang, C. H. Chien, S. M. Lin, B. R. Tserng, and C. S. Chen,Int. J. Determatol. 23, 258 (1984).
F. H. Lu, C. K. Yang, and K. H. Ling,J. Formosan Med. Assoc. 74, 596 (1975).
C. J. Chen, Y. C. Chuang, T. M. Lin, and H. Y. Wu,Cancer Res. 45, 5895 (1985).
K. P. Chen and H. Y. Wu,J. Formosan Med. Assoc. 68, 291 (1969).
S. M. Lin, C. H. Chiang, and M. H. Yang,Biol. Trace Element Res. 8, 11 (1985).
S. M. Lin and M. H. Yang,Biol. Trace Element Res. 15, 213 (1988).
F. J. Lu, Y. Yamamura, and H. Yamauchi,J. Formosan Med. Assoc. 87, 65 (1985).
S. L. Chen, S. J. Yeh, T. H. Lin., and M. H. Yang,Environ. Res. (in press), 1993.
Y. S. Ryabukhin,Report. IAEA/RL/41H, 1978, P. 8.
H. A. Schraeder and A. P. Nason,J. Invest. Dermatol. 53, 71 (1971).
S. M. Lin, C. H. Chiang, C. L. Tseng, and M. H. Yang,Radiochem. Radioanal. Lett. 56, 2617 (1983).
J. M. Lo, J. C. Wee, M. H. Yang, and S. J. Yeh,J. Radioanal. Chem. 72, 571 (1982).
J. S. Chen, N. S. Wong, J. C. Wei, J. N. Ke, M. H. Huang, and M. H. Yang,Chemistry (The Chinese Chem. Soc., Taiwan, China) 40, 45 (1985).
S. M. Lin, C. H. Chiang, C. L. Tseng, and M. H. Yang,J. Radioanal. Nucl. Chem. Lett. 96, 153 (1985).
S. M. Lin,Radioisotopes 32, 155 (1983).
T. M. Kao and S. R. Kao,J. Formosan Med. Assoc. 53, 272 (1954).
M. Laker,Lancet 2, 260 (1982).
J. T. Hindmarsh, O. R. McLetchie, L. P. M. Hefferman, O. A. Hayne, H. A. Ellenbeger, R. F. McCurdy, and H. J. Thiebaux,J. Anal. Toxicol. 1, 270 (1979).
Government of Canada, Department of National Health and Welfare, Public statement refers to 5 ppm arsenic hair concentration as criterion for assessing marginal increase, 1976.
H. J. Kobberecht and H. A. Deelstra,Clinical. Chimica. Acta 136, 107 (1984).
S. Yeh and S. W. How, Reports, Institute of Pathology, National Taiwan University,14, 25 (1963).
W. P. Tseng,J. Formosan Med. Assoc. 74, 37 (1975).
F. J. Lu,Natl. Sci. Counc. Monthly Taipei, Taiwan, R. O. C. 6, 388 (1978).
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Pan, T.C., Lin, T.H., Tseng, C.L. et al. Trace elements in hair of blackfoot disease. Biol Trace Elem Res 39, 117–128 (1993). https://doi.org/10.1007/BF02783182
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DOI: https://doi.org/10.1007/BF02783182