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Neonatal gram negative pyogenic meningitis: therapeutic evaluation

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Abstract

Thirty babies with gram negative neonatal pyogenic meningitis were studied for therapeutic evaluation of various drug combinations. Group I received ampicillin and gentamycin and group II received ampicillin with chloramphenicol all intravenously. These drugs were continued for 2 wk after bacteriological cure. Group III include those from group I and II who did not show bacteriological cure even after 7 days of therapy and were given sulphamethoxazole—trimethoprim preparation intravenously for 3 to 4 days and continued orally for another 2 wk. Mortality was 75 per cent (9 cases) in group I compared to 16·6 percent (9 cases) in group II. Group III children developed more complications like cerebral palsy and hydrocephalus.

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Authors and Affiliations

  1. Department of Neonatology, Institute of Child Health, Niloufer Hospital for Women and Children, Hyderabad, A.P.

    M. D. Rami Reddy M.D. (Assistant Professor of Pediatrics), S. Karan M.D. & S. V. Reddy M.D.

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  1. M. D. Rami Reddy M.D.
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  2. S. Karan M.D.
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  3. S. V. Reddy M.D.
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Rami Reddy, M.D., Karan, S. & Reddy, S.V. Neonatal gram negative pyogenic meningitis: therapeutic evaluation. Indian J Pediatr 52, 53–56 (1985). https://doi.org/10.1007/BF02754719

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  • DOI: https://doi.org/10.1007/BF02754719

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