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Nodular amyloidosis: Case report and literature review

  • Basic / Clinical Science
  • Published:
Journal of Cutaneous Medicine and Surgery

Abstract

Background

Amyloidosis refers to a group of depositional diseases that are classified into two main types: systemic and localized. Large nodules of localized cutaneous amyloidosis of the nasal ala and surrounding skin are rare and the treatment is often unsatisfactory.

Objective

We report a case of rapidly enlarging, localized, nodular cutaneous amyloidosis of the nose and the surrounding skin with a brief review of the current literature regarding treatment of this rare disease.

Conclusion

Nodular amyloidosis can be treated successfully with cold steel excision in combination with carbon dioxide laser. Close followup of these patients is warranted, as nodular amyloidosis may be the precursor to systemic amyloidosis.

Sommaire

Antécédents

L’amyloïdose se rapporte à un groupe de maladies caractérisées par le dépôt de substance amyloïde et classées en deux grands types, généralisé et localisé. L’amyloïdose cutanée localisée sous forme de gros nodules siégeant sur les ailes du nez et dans les tissus cutanés avoisinants est une affection rare dont le traitement donne souvent des résultats peu satisfaisants.

Objectif

Rapporter un cas d’amyloïdose cutanée localisée sous forme de nodules à évolution rapide au niveau du nez et des tissus cutanés avoisinants en donnant un bref aperçu de la documentation actuelle sur le traitement de cette rare maladie.

Conclusion

L’amyloïdose nodulaire peut être traitée avec succès par exérèse à l’acier à froid combinée à un traitement au laser à gaz carbonique. Comme l’amyloïdose nodulaire peut être un signe avant-coureur d’amyloïdose généralisée, les patients qui en sont atteints doivent faire l’objet d’un suivi étroit.

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Authors and Affiliations

  1. Department of Otolaryngology, Albert Einstein College of Medicine, 10461, Bronx, New York

    Rajesh S. Kakani MD

  2. Department of Dermatology, St. Barnabas Hospital, 10457, Bronx, New York

    Amy E. Goldstein & Cindy Hoffman

  3. Department of Pathology, Coney Island Hospital, 11235, Brooklyn, New York

    Irina Meisher

Authors
  1. Rajesh S. Kakani MD
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  2. Amy E. Goldstein
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  3. Irina Meisher
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  4. Cindy Hoffman
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Corresponding author

Correspondence to Rajesh S. Kakani MD.

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Cite this article

Kakani, R.S., Goldstein, A.E., Meisher, I. et al. Nodular amyloidosis: Case report and literature review. J Cutan Med Surg 5, 101–104 (2001). https://doi.org/10.1007/BF02737862

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  • DOI: https://doi.org/10.1007/BF02737862

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