Abstract
A pectin present in the juice of the inflorescence stalk of plantain(Musa sapientum) has been isolated. The material contained 32.4% hexoses and 52.5% uronic acid. On administration to rats fed both cholesterol free and cholesterol diet, this material showed significant lowering of cholesterol and triglycerides in the serum, liver and aorta. There was decreased cholesterogenesis in the liver as was evident from decreased activity of hydroxymethylglutaryl coenzyme A reductase and decreased incorporation of labelled acetate into hepatic cholesterol. Hepatic bile acids showed significant increase and there was increased fecal excretion of neutral sterols and bile acids. Release of lipoproteins into the circulation was lower. The material also caused increase in the activity of lipoprotein lipase in the heart and adipose tissue and also of plasma lecithin: cholesterol acyl transferase
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Abbreviations
- CPC:
-
Cety1 pyridinium chloride
- TCA:
-
trichloroacetic acid
- HMG CoA:
-
hydroxymethylglutaryl coenzyme A
- VLDL:
-
very low density lipoprotein
- LDL:
-
low density lipoprotein
- LCAT:
-
lecithin: cholesterol acyl transferase
- HDL:
-
high density lipoprotein
- LPL:
-
lipoprotein lipase
References
Annie Abraham and Kurup, P. A. (1988)J. Biosci.,13, 393.
Bitter, T. and Muir, H. M. (1962)Anal. Biochem.,4, 330.
Bobek, P. and Chrovathova, V.,(1984)Physiol. Bohemoslov.,33, 230.
Burstein, M. and Scholnick, H. R. (1973)Adv. LipidRes.,11, 67.
Cameron, G. R., Milton R. F. and Allen, J. W. (1943)Lancet,1, 179.
Dubois, M., Gilles, K. A., Hamilton, J. K., Rebers, P. A. and Smith, F. A. (1966)Methods Enzymol.,8, 93.
Frank, A., Hans, H., Maria, P. and Christian, A. B. (1986)J. Nutr.,116, 70.
Fry, S. C. (1983)Planta,157, 111.
Grundy, S. M., Ahrens, E. H. and Miettinen, T. A. (1965)J. LipidRes.,6, 397.
Judd, Patricia, S., and Truswell (1985)J. Nutr.,53, 409.
Kelly, James, J. and Alan, C. Tsai (1978)J. Nutr. 108, 630.
Krauss, R. N., Wind Muller, H. G., Levy, R. I. and Frederickson, D. S. (1974)J. Clin. Invest.,54, 1107.
Lakshmi Prabha, A. N., Leelamma, S. and Kurup, P. A. (1988)J. Biosci.,13, 263.
Leelamma, S., Menon, P. V. G. and Kurup, P. A. (1978)Indian J. Exp. Biol.,16, 29.
Lowry, O. H., Rosebrough, N. J., Farr, A. L. and Randall, R. J. (1951)J. Biol. Chem.,193, 265.
Menon, P. V. G. and Kurup, P. A. (1976)Biomedicine,24, 248.
Molly Thomas, Leelamma, S. and Kurup, P. A. (1983)J. Nutr. 113, 1104.
Okishio, T., Nair, P. P. and Cordon, M. (1967)Biochem. J.,102, 652.
Robert, H. Palmer (1969)Methods Enzymol.,15, 280.
Selvendran, R. R., Stevens, B. J. H. and O’Neill, M. A. (1985) inBiochemistry of plant cell walls, SEB Seminar Series (eds C. T. Brett and J. R. Hillman) (Cambridge: Cambridge University Press) vol. 28, p. 39.
Venugopala Rao, A., Ramakrishnan, S. (1975)Clin. Chem.,21, 1523.
Warnick, R. G. and Albers, J. (1978)J. Lipid Res.,19, 65.
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Gomathy, R., Vijayalekshmi, N.R. & Kurup, P.A. Hypolipidemic principle of the inflorescence stalk of plantain (Musa sapientum). J Biosci 14, 301–309 (1989). https://doi.org/10.1007/BF02716691
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DOI: https://doi.org/10.1007/BF02716691