Abstract
It is shown that apoC-III, but not other apoC proteins, components of very low density lipoproteins (apoC-I, apoC-II, apoC-III), reduced the rate of mitochondrial respiration in various metabolic states. This effect depended on the dose of apoprotein, type of oxidized substrate, and the presence of Ca ions in the incubation medium. ApoC-III completely blocked oxidative phosphorylation during oxidation of palmitoyl carnitine by mitochondria, while the respiration rate in metabolic state 4 remained unchanged.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
A. N. Klimov and N. G. Nikul'cheva,Lipids, Lipoproteins, and Atherosclerosis [in Russian], St. Petersburg (1995).
N. I. Shalbueva, I. G. Shabalina, and N. G. Kolosova,Byull. Sibirsk. Otdeleniya Rossiisk. Akad. Med. Nauk, Mo. 3, 52–57 (1998).
B. Chance and G. R. Williams,J. Biol. Chem.,217, 409–427 (1955).
O. H. Lowry, N. J. Rosenbrough, A. L. Farr, and R. J. Randall,Ibid. 193, No. 1, 265–275 (1951).
L. E. Panin, A. R. Kolpakov, D. I. Kuzmenko,et al., Phys. Chem. Biol. Med.,2, 27–35 (1995).
E. C. Weinbach,Anal. Biochem.,2, No. 4, 335–343 (1961).
Author information
Authors and Affiliations
Additional information
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 8, pp. 184–186, August, 2000
Rights and permissions
About this article
Cite this article
Panin, L.E., Shalbueva, N.I. & Polyakov, L.M. Effects of apolipoproteins C on oxidative phosphorylation in rat liver mitochondria. Bull Exp Biol Med 130, 769–771 (2000). https://doi.org/10.1007/BF02681941
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02681941