Abstract
Male weanling rats of the Sprague-Dawley strain were made essential fatty acid (EFA)-deficient by feeding them a fat-free diet for five months. The animals were then fed a supple-ment of methyltrans-9,trans-12-octadecadienoate (methyl linoelaidate), as 5% of the dietary calo-ries (approximately 400 mg/animal/day) for 19 days, and killed by exsanguination. The com-position of the liver, kidney, epididymal and plasma lipids was determined and compared with that obtained from EPA-deficient rats given oral supplements of methylcis-9,cis-12-octadeca-dienoate (linoleate) and methylcis-9,trans-12- octadecadienoate. Linoelaidic acid was depos-ited in the phospholipids, sterol esters and tri-glycerides in all of the tissues examined. Iso-lation analysis of the fatty acids showed no evidence that linoelaidic acid was converted to higher polyunsaturated fatty acids in the EFA-deficient rat.
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Supported in part by U. S. Public Health Service Grant No. AM 04942.
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Privett, O.S., Blank, M.L. Studies on the metabolism of linoelaidic acid in the essential fatty acid-deficient rat. J Am Oil Chem Soc 41, 292–297 (1964). https://doi.org/10.1007/BF02667022
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DOI: https://doi.org/10.1007/BF02667022