Abstract
Hypercholesteremic rats were used to investigate the lipid depressant activities of lyophilized whole fish prepared from menhaden, silver salmon, mullet, and ocean perch. Ingestion of the whole fish supplements promoted a significant reduction in the circulating levels of cholesterol and phospholipids, and in the TC/TP ratios of blood lipids from the rat. The effects of whole fish were duplicated by feeding rats proportionate amounts of the oils found in these fish supplements. These supplements had similar, but less dramatic, effects on the liver lipids of the rats. The nonlipid components, isolated from the fish, had no apparent influence on the distribution of lipids in the blood and liver tissues. The preparations of lipid and nonlipid components of the fish are described, and the GLC analyses of marine oils are discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Peifer, J. J., F. Janssen, P. Ahn, W. Cox, and W. O. Lundberg, Arch. Biochem. Biophys.,86, 302 (1960).
Ahrens, E. H., W. Insull, H. Hirsch, W. Stoffel, M. L. Peterson, J. W. Farquhar, T. Miller, and H. J. Thomasson, Lancet,1, 115 (1959).
Peifer, J. J., and W. O. Lundberg, Federation Proc.,20, 93 (1961).
Peifer, J. J., S. Ishio, F. Janssen, P. Ahn, and W. O. Lundberg, ms. in preparation.
Bronte-Stewart, B., A. Antonis, L. Eales, and J. F. Brock, Lancet1, 521 (1956).
Hauge, J., and R. Nicolaysen, Acta Physiol. Scand.,43, 359 (1958).
De Groot, A. P., and S. A. Reed, Nature,183, 1191 (1959).
Kokatnur, M. G., and F.A. Kummerow, J. Nutrition,75, 319 (1961).
Peifer, J. J., Mikrochimica Acta, 1962, in press.
Peifer, J. J., R. Muesing, F. Janssen, and R. Leif, Abstracts of the 35th Fall Meeting of the A.O.C.S. (see footnote 1).
Metcalfe, L. D., and A. A. Schmitz, Anal. Chem.33, 363 (1961).
Farquhar, J. W., W. Insull, P. Rosen, W. Stoffel, and E. H. Ahrens, Nutritional Reviews,17, No. 8, Part IL 1959, pp. 1–30.
Metcalfe, L. D., Nature,188, 142 (1960).
Tandy, R. K., F. T. Lindgren, W. H. Martin, and R. D. Wills, Anal. Chem.,33, 665 (1961).
Abell, L. L., B. B. Levy, B. B. Brodie, and F. E. Kendall, J. Biol. Chem.195, 357 (1952).
King, E. J., Biochem. J.,26, 292 (1932).
Mead, J. F., and M. L. Gauze, Proc. Soc. Exp. Biol. Med.,106, 4 (1961).
Wood, J. D., and J. Biely, Can. J. Biochem. Physiol.,38, 19 (1960).
Author information
Authors and Affiliations
Additional information
Researches supported by U.S. Department of Interior, Fish & Wildlife Service, American Heart Association, U.S. Public Health service and the Hormel Foundation.
These studies were completed during the tenure of an Established Investigatorship from the American Heart Association.
About this article
Cite this article
Peifer, J.J., Janssen, F., Muesing, R. et al. The lipid depressant activities of whole fish and their component oils. J Am Oil Chem Soc 39, 292–296 (1962). https://doi.org/10.1007/BF02638120
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02638120