Summary and Conclusions
During alimentary lipemia induced in dogs by the feeding of saturated or unsaturated fats no significant alteration occurred in phagocytic function as indicated by colloidal carbon removal and colloidal gold tissue distribution studies. The cellular distribution of intravenously administered triglyceride indicated that most of the injected triglyceride was found in the isolated hepatic parenchymal cell. The distribution of an intravenously administered free cholesterol emulsion indicated initial localization in the parenchymal cell and a later elevation in the Kupffer cell. These findings suggest that both hepatic parenchymal and Kupffer cells participate in the removal of chylomicra; the parenchymal cell has the greatest role. The late elevation in cholesterol content of the Kupffer cell is indicative of a metabolic or excretory function of these cells in cholesterol metabolism.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Daoust, R., “Liver Function,” p. 3–11, edited byBrauer, R. W., Am. Inst. Biol. Sci., Washington, D. C. (1958).
Jaffe, R. H., and Berman, S. L., Arch. Path.,5, 1020–1027 (1928).
Byers, S. O., St. George, S., and Friedman, M., “Physiopathology of the Reticuloendothelial System,” edited by Halpern, B. N., p. 128–147, Charles C. Thomas, publisher, Springfield, Ill. (1957).
Di Luzio, N. R., Simon, K. A., and Upton, A. C., Arch. Path.,64, 649–656 (1957).
Biozzi, G., Benacerraf, B., and Halpern, B. N., British J. Exp. Path.,34, 441–457 (1953).
Di Luzio, N. R., Am. J. Physiol.,196, 884–886 (1959).
Di Luzio, N. R., and Zilversmit, D. B., Am. J. Physiol.,180, 563–565 (1956).
Zilversmit, D. B., Salky, N. K., Trumbull, M. L., and McCandless, E. L., J. Lab. and Clin. Med.,48, 386–391 (1956).
Folch, J., Ascoli, I., Leos, M., Meath, J. A., and LeBaron, F. N., J. Biol. Chem.,191, 833–841 (1951).
King, E. J., Biochem. J.,26, 292–297 (1932).
Sperry, W. M., and Webb, M., J. Biol. Chem.,187, 97–106 (1950).
Zilversmit, D. B., and Bollman, J. L., Arch. Biochem. and Biophys.,63, 64–72 (1956).
Harbitz, F., Arch. Path.,4, 507–527 (1927).
Woerner, C. A., Anat. Record.,104, 61–77 (1949).
Murray, R. G., and Freeman, S., J. Lab. and Clin. Med.,38, 56–69 (1951).
Waddell, W. R., Geyer, R. P., Clarke, E., and Sture, F.J., Am. J. Physiol.,177, 90–94 (1954).
Morris, B., and French, J. E., Quart. J. Exp. Physiol.,43, 180–188 (1958).
Fawcett, D. W., J. National Cancer Inst.,15, 1475–1503 (1955).
Bailey, J. M., Gey, G. O., and Gey, M. K., Proc. Soc. Exptl. Biol. and Med.,100, 686–692 (1959).
Stambul, J., “The Mech-nisms of Disease,” Sections 3 and 4, Froben Press Inc., New York, N. Y., 1952.
Author information
Authors and Affiliations
Additional information
Supported in part by a grant from the Public Health Service (H-2320) and the Atomic Energy Commission.
Lederle Medical Faculty Awardee.
About this article
Cite this article
Di Luzio, N.R. Hepatic participation in lipid metabolism. J Am Oil Chem Soc 37, 163–165 (1960). https://doi.org/10.1007/BF02631218
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02631218