Summary
Sixty-four malignant cell lines were examined for interleukin-1 (IL-1) activities in their conditioned medium using thymocyte and fibroblast proliferation assays. Sixteen cell lines showed high IL-1 activity. Comparison of these activities with human IL-1 showed similarity between some biological properties. However there was no correlation between cell origin and IL-1 activity. These results suggest the possibility that most malignant cells may produce an IL-1-like factor.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Auron, P. E.; Webb, A. C.; Rosenwasser, L. J., et al. Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. Proc. Natl. Acad. Sci. USA 81:7907–7911; 1984.
Birchall, N.; Kupper, T.; McGuire, J. Recombinant human interleukin-1 alpha is mitogenic for human keratinocytes. J. Cell Biol. 105:109a(abstract); 1987.
Chambers, T. J.; McSheehy, P. M. J.; Thomson, B. M., et al. The effect of calcium-regulating hormones and prostaglangins on bone resorption by osteoclasts disaggregated from neonatal rabbit bones. Endocrinology 116:234–239; 1985.
Dinarello, C. A. Interleukin-1. Rev. Infect. Dis. 6:51–95; 1984.
Dower, S. K.; Kronheim, S. R.; March, C. J., et al. Detection and characterization of high affinity plasma membrane receptors for human interleukin 1. J. Exp. Med. 162:501–515; 1985.
Fontana, A.; Hengartner, H.; Tribolet, N., et al. Glioblastoma cells release interleukin 1 and factors inhibiting interleukin 2 mediated effects. Immunology 132:1837–1844; 1984.
Gospodarowicz, D.; Cheng, J.; Lui, G.-M., et al. Isolation of brain fibroblast growth factor by heparin-sepharose affinity chromatography: Identity with pituitary fibroblast growth factor. Proc. Natl. Acad. Sci. USA 81:6963–6967; 1984.
Grabner, G.; Luger, T. A.; Smolin, G., et al. Corneal epithelial cell-derived thymocyte activating factor (CETAF). Invest. Ophthalmol. Vis. Sci. 23:757–763; 1982.
Hauser, C.; Dayer, J.-M.; Jaunin, F., et al. Intracellular epidermal interleukin 1-like factors in the human epidermoid carcinoma cell line A431. cell. Immunol. 100:89–96; 1986.
Hauser, C.; Saurat, J. H.; Schmitt, A., et al. Interleukin 1 is present in normal human epidermis. J. Immunol. 136:3317–3323; 1986.
Kampschmidt, R. F. The numerous postulated biological manifestations of interleukin-1. J. Leukocyte Biol. 36:341–355; 1984.
Kokoschka, E. M.; Luger, T. A.; Koch, A., et al. Melanoma cell production of an interleukin 1-like thymocyte activating factor. Arch. Dermatol. 276:267(abstract); 1984.
Kurokawa, T.; Sasada, R.; Iwane, M., et al. Cloning and expression of cDNA encoding human basic fibroblast growth factor. FEBS Lett. 213:189–194; 1987.
Lobb, R.; Sasse, J.; Sullivan, R., et al. Purification and characterization of heparin-binding endothelial cell growth factors. Biol. Chem. 261:1924–1928; 1986.
Lomedico, P. T.; Bugler, U.; Hellman, C. P., et al. Cloning and expression of murine interleukin-1 cDNA in Escherichia coli. Nature 312:458–462; 1984.
Lovett, D. H.; Ryan, J. L.; Sterzel, R. B. A thymocyte-activating factor derived from glomerular mesangial cells. J. Immunology 130:1796–1801; 1983.
Luger, T. A.; Oppenheim, J. J. Characteristics interleukin 1 and epidermal cell-derived thymocyte activating factor. J. Adv. Inflammation Res. 5:1–25; 1983.
Luger, T. A.; Stadler, B. M.; Katz, S. I., et al. Epidermal cell (keratinocyte) derived thymocyte activating factor. J. Immunology 127:1493–1498; 1981.
Luger, T. A.; Stadler, B. M.; Luger, B. M., et al. Characteristics of an epidermal cell thymocyte activating factor (ETAF) produced by human epidermal cells and a human squamous cell carcinoma cell line. J. Invest. Dermatol. 81:187–193; 1983.
March, C. J.; Mosley, B.; Larsen, A., et al. Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature 315:641–647; 1985.
Okai, Y.; Tashiro, H.; Yamashita, U. 3T3 fibroblasts are stimulated by 12-0-tetradecanoyl-phorbol-13-acetate to produce thymocyte activating factors. FEBS Lett. 142:93–95; 1982.
Okamoto, T.; Wu, D.; Kan, M., et al. Production of a basic FGF-like growth factor by human epidermoid carcinoma. In Vitro 23:41(abstract); 1987.
Onozaki, K.; Matsushima, K.; Aggarwal, B. B., et al. Human interleukin 1 is a cytocidal factor for several tumor cell lines. J. Immunol. 132:1837–1844; 1984.
Oppenheim, J. J.; Kovacs, E. J.; Matsushima, K., et al. There is more than one interleukin 1. Immunol. Today 7:45–56; 1986.
Postlethwaite, A. E.; Lachman, L. B.; Mainardi, C. L., et al. Interleukin 1 stimulation of collagenase production by cultured fibroblasts. J. Exp. Med. 157:801–806; 1983.
Rogeli, S.; Weinberg, R. A.; Fanning, P., et al. Basic fibroblast growth factor fused to a signal peptide transforms cells. Nature 331:173–175; 1988.
Sauder, D. N.; Dinarello, C. A.; Morhenn, V. B. Langerhans cell production of interleukin-1. J. Invest. Dermatol. 82:605–607; 1984.
Schmidt, J. A.; Mizel, S. B.; Cohen, D., et al. Interleukin 1, a potential regulator of fibroblast proliferation. J. Immunol. 128:2177–2182; 1982.
Thomas, K.; Rios-Chandelore, M.; Gimemez-Gallego, G., et al. Pure brain-derived acidic fibroblast growth factor is a potent angiogenic vascular endothelial cell mitogen with sequence homology to interleukin 1. Proc. Natl. Acad. Sci. USA 82:6409–6413; 1985.
Thomson, B. M.; Saklatvata, J.; Chambers, T. J. Osteoblasts mediate interleukin 1 stimulation of bone resorption by rat osteoclasts. J. Exp. Med. 164:104–112; 1986.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Miyauchi, S., Moroyama, T., Kyoizumi, S. et al. Malignant tumor cell lines produce interleukin-1-like factor. In Vitro Cell Dev Biol 24, 753–758 (1988). https://doi.org/10.1007/BF02623644
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02623644