Skip to main content

Advertisement

SpringerLink
Log in

Histogenesis of microscopic adenoma and hyperplastic (metaplastic) gland in nonpolyposis coli

  • Published:
Diseases of the Colon & Rectum

Abstract

Histogenesis of microscopic adenoma in nonpolypoid colons (those not included in the special disease group of familial polyposis coli) was investigated using complete serial sections with the following results: Adenoma arises from basal cells in the deep layer of the mucosa; and two types of basal cells found were 1) those which had already undergone changes to adenoma and 2) those which are in their transitional stage to adenomas. Early-phase growth of adenoma is brought about by branching. Individual hyperplastic (metaplastic) glands constituting so-called hyperplastic (metaplastic) polyps are considered to be only an expression of one variant in the growing process of adenomas and the glands showing these changes most characteristically have a serrated pattern. Based on these findings, the histogenesis of adenoma in nonpolypoid colons is shown schematically.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Oohara T, Ogino A, Saji K, Tohma H. Studies on the differences of background mucosa among single advanced carcinoma and benign diseases of the large intestine, and familial polyposis coli. Cancer 1980;45:1637–45

    Article  PubMed  CAS  Google Scholar 

  2. Lane N, Lev R. Observations on the origin of adenomatous epithelium of the colon: serial section studies of minute polyps in familial polyposis. Cancer 1963;16:751–64.

    Article  PubMed  CAS  Google Scholar 

  3. Spjut HJ, Spratt JS, Jr. Endemic and morphologic similarities existing between spontaneous colonic neoplasms in man and 3:2-dimethyl-4-aminobiphenyl induced colonic neoplasms in rats. Ann Surg 1965;161:309–24.

    Article  PubMed  CAS  Google Scholar 

  4. Springer P, Springer J, Oehlert W. Die Vorstufen des 1,2-Dimethylhydrazininduzierten Dick-und Dünndarmcarcinoms der Ratte. Z Krebsforsch 1970;74:236–40.

    Article  PubMed  CAS  Google Scholar 

  5. Wiebecke B, Krey U, Löhrs U, Eder M. Morphological and autoradiographical investigations on experimental carcinogenesis and polyp development in the intestinal tract of rats and mice. Virchow's Arch Abt A Pathol Anat 1973;360:179–93.

    Article  CAS  Google Scholar 

  6. Lipkin M. Phase 1 and phase 2 proliferative lesions of colonic epithelial cells in diseases leading to colonic cancer. Cancer 1974;34:878–88.

    Article  PubMed  CAS  Google Scholar 

  7. Cole JW, McKalen A. Studies on the morphogenesis of adenomatous polyps in the human colon. Cancer 1963;16:998–1002.

    Article  PubMed  CAS  Google Scholar 

  8. Deschner EE, Lipkin M, Solomon C. Study of human rectal epithelial cellsin vitro. II. H3-thymidine incorporation into polyps and adjacent mucosa. J Natl Cancer Inst 1966;36:849–57.

    CAS  Google Scholar 

  9. Morson BC. Some peculiarities in the histology of intestinal polyps. Dis Colon Rectum 1962;5:337–44.

    Google Scholar 

  10. Oohara T, Ogino A, Tohma H. Microscopic adenoma in nonpolyposis coli: incidence and relation to basal cells and lymphoid follicles. Dis Colon Rectum 1981;24:120–6.

    Article  PubMed  CAS  Google Scholar 

  11. Riddell RH. The precarcinomatous phase of ulcerative colitis. Curr Top Pathol 1976;63:179–219.

    PubMed  CAS  Google Scholar 

  12. WHO. Histological typing of intestinal tumors. Geneva: WHO, 1976.

    Google Scholar 

  13. Eide TJ, Stalsberg H. Polyps of the large intestine in Northern Norway. Cancer 1978;42:2839–48.

    Article  PubMed  CAS  Google Scholar 

  14. Kurzon RM, Ortega R, Rywlin AM. The significance of papillary features in polyps of the large intestine. Am J Clin Pathol 1974;62:447–54.

    PubMed  CAS  Google Scholar 

  15. Lane N, Kaplan H, Pascal RR. Minute adenomatous and hyperplastic polyps of the colon: divergent patterns of epithelial growth with specific associated mesenchymal changes; contrasting roles in the pathogenesis of carcinoma. Gastroenterology 1971;60:537–51.

    PubMed  CAS  Google Scholar 

  16. Correa P, Duque E, Cuello C, Haenszel W. Polyps of the colon and rectum in Cali, Colombia. Int J Cancer 1972;9:86–96.

    Article  PubMed  CAS  Google Scholar 

  17. Ekelund G, Lindström C. Histopathological analysis of benign polyps in patients with carcinoma of the colon and rectum. Gut 1974;15:654–63.

    PubMed  CAS  Google Scholar 

  18. Pagtalunan RJ, Dockerty MB, Jackman RJ, Anderson MJ Jr. The histopathology of diminutive polyps of the large intestine. Surg Gynecol Obstet 1965;120:1259–65.

    PubMed  CAS  Google Scholar 

  19. Arthur JF. The significance of small mucosal polyps of the rectum. Proc R Soc Med 1962;55:703–4.

    PubMed  CAS  Google Scholar 

  20. Arthur JF. Structure and significance of metaplastic nodules in the rectal mucosa. J Clin Pathol 1968;21:735–43.

    PubMed  CAS  Google Scholar 

  21. Wiebecke B, Brandts A, Eder M. Epithelial proliferation and morphogenesis of hyperplastic adenomatous and villous polyps of the human colon. Virchow's Arch Abt A Pathol Anat 1974;364:35–49.

    Article  CAS  Google Scholar 

  22. Melnyk CS, Braucher RE, Kirsner JB. Colon mucosa response to injury. I. Morphological study. Gastroenterology 1966;51:43–9.

    PubMed  CAS  Google Scholar 

  23. Heilmann KL. Reversible morphological changes of rectal mucosa in vitamin B12 deficiency. Pathol Res Pract 1978;163:261–6.

    PubMed  CAS  Google Scholar 

  24. Lockhart-Mummery JP, Dukes C. The precancerous changes in the rectum and colon. Surg Gynecol Obstet 1928;46:591–6.

    Google Scholar 

  25. Westhues H. Die pathologisch-anatomischen Grundlagen der Chirurgie des Rektumkarzinoms. Leipzig: Geort Thieme Verlag, 1934.

    Google Scholar 

  26. Hayashi T, Yatani R, Apostol J, Stemmermann GN. Pathogenesis of hyperplastic polyps of the colon: a hypothesis based on ultrastructure and in vitro cell kinetics. Gastroenterology 1974;66:347–56.

    PubMed  CAS  Google Scholar 

  27. Kaye GI, Fenoglio C, Pascal RR, Lane N. Comparative electron microscopic features of normal hyperplastic, and adenomatous human colonic epithelium. Gastroenterology 1973;64:926–45.

    PubMed  CAS  Google Scholar 

  28. Goldman H, Ming S, Hickok DF. Nature and significance of hyperplastic polyps of the human colon. Arch Pathol 1970;89:349–54.

    PubMed  CAS  Google Scholar 

  29. Kozuka S. Premalignancy of the mucosal polyp in the large intestine. I. Histologic gradation of the polyp on the basis of epithelial pseudostratification and glandular branching. Dis Colon Rectum 1975;18:483–93.

    Article  PubMed  CAS  Google Scholar 

  30. Stemmerman GN, Yatani R. Diverticulosis and polyps of the large intestine: a necropsy study of Hawaii Japanese. Cancer 1973;31:1260–70.

    Article  Google Scholar 

  31. Cooper HS, Patchefsky AS, Marks G. Adenomatous and carcinomatous changes within hyperplastic colonic epithelium. Dis Colon Rectum 1979;22:152–6.

    Article  PubMed  CAS  Google Scholar 

  32. Hancke E, Remmele W. Colorectale Polypen: Pathologischanatomische und statistische Untersuchungen an 3037 Polypen. Chirurg 1978;49:757–68.

    PubMed  CAS  Google Scholar 

  33. Czernobilsky B, Tsou KC. Adenocarcinoma, adenomas and polyps of the colon: histochemical study. Cancer 1968;21:165–77.

    Article  PubMed  CAS  Google Scholar 

  34. Wattenberg LW. A histochemical study of five oxidative enzymes in carcinoma of the large intestine in man. Am J Pathol 1959;35:113–37.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Third Department of Surgery, Faculty of Medicine, University of Tokyo, 3-28-6, Mejirodai, Bunkyo-ku, 112, Tokyo, Japan

    Takeshi Oohara M.D., Akihito Ogino & Hiroyuki Tohma M.D.

  2. Tohma Hospital, Kumagay City, Japan

    Takeshi Oohara M.D., Akihito Ogino & Hiroyuki Tohma M.D.

Authors
  1. Takeshi Oohara M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Akihito Ogino
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hiroyuki Tohma M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Oohara, T., Ogino, A. & Tohma, H. Histogenesis of microscopic adenoma and hyperplastic (metaplastic) gland in nonpolyposis coli. Dis Colon Rectum 24, 375–384 (1981). https://doi.org/10.1007/BF02603423

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02603423

Key words

Search

Navigation