Summary
Most types of neoplastic lesions seen in human intestinal mucosa were reproduced experimentally in rats and mice after application of 1,2-dimethylhydrazine. Tumor distribution displayed dose-related variations. The relative tumor frequency in the small intestine rose after higher dosage of the carcinogen, with preponderance of the upper segments. Furthermore there were certain species specific differences between rats and mice concerning the tumor distribution within the large intestine.
Primary nonpolypous carcinomas with early infiltration developed as a consequence of rapid epithelial dedifferentiation and malignant transformation, predominantly in the small intestine. Benign and malignant polypous tumors were much more frequent in the large than in the small intestine.
Benign adenomatous and villous polyps of the colon develop after preceding mucosal hyperplasia due to partial loss of epithelial differentiation. As demonstrated by quantitative autoradiographical findings, the proliferation zone in these lesions is extended to the mucosal surface. Additionally, the zone of maximal epithelial proliferation is transposed to a mucosal layer near the surface. This qualitative change in the mode of epithelial proliferation compared with normal and hyperplastic mucosa is the essential factor in the development of benign neoplastic polyps.
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Wiebecke, B., Krey, U., Löhrs, U. et al. Morphological and autoradiographical investigations on experimental carcinogenesis and polyp development in the intestinal tract of rats and mice. Virchows Arch. Abt. A Path. Anat. 360, 179–193 (1973). https://doi.org/10.1007/BF00542979
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DOI: https://doi.org/10.1007/BF00542979