Abstract
The red emission (632 nm) of a low-power (about 10 mW) HeNe laser is used to excite liposome-bound haematoporphyrin dimethylester localized in a solid tumour implanted in the mouse leg (MS-2 sarcoma). Fluorescence from the target area, filtered at >710 nm, is converted into visible green light by means of a near-infrared-visible image converter. The photographically recorded images clearly reveal differences in fluorescence intensity of tumour tissues with respect to normal tissues. Clinical application of the procedure is proposed, and the expected advantage with respect to current fluorescence endoscopy are discussed.
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Zandomeneghi, M., Festa, C., Angelletti, C.A. et al. Detection of near-infrared porphyrin fluorescence excited in experimental animal tumour by the HeNe laser. Laser Med Sci 3, 99–102 (1988). https://doi.org/10.1007/BF02593796
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DOI: https://doi.org/10.1007/BF02593796