Abstract
Electrophysiologic findings including multifocal electroretinogram and visual evoked cortical potentials were studied in a patient with multiple evanescent white dot syndrome. A 19-year-old woman was diagnosed as having multiple evanescent white dot syndrome because of decreased visual acuity, white dots on fundus examination and hyperfluorescence of the white dots in the right eye. The amplitude of the flicker electroretinogramwas reduced, but the single-flash electroretinogram was within the normal range. The P100 latency of the pattern visual evoked cortical potentials was slightly prolonged. The amplitudes of multifocal electroretinogram were, markedly reduced in the area corresponding to the scotoma and moderately reduced in other regions of the central field in the affected eye. The results suggest that the retinal dysfunction area is wider than that detected by subjective methods or conventional electrophysiological examinations. The delayed recovery of the visual evoked cortical potential latency suggests the involvement of the optic nerve in multiple evanescent white dot syndrome.
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Abbreviations
- MEWDS:
-
multiple evanescent white dot syndrome
References
Jampol LM, Sieving PA, Pugh D, Fishman GA, Gilbert H. Multifocal evanescent white dot syndrome: clinical finding. Arch Ophthalmol 1984; 102: 671–4.
Sieving PA, Fishman GA, Jampol LM, Pugh D. Multiple evanescent white dot syndrome, II. electrophysiology of the photoreceptors. During retinal pigment epithelial disease. Arch Ophthalmol 1984; 102: 675–9.
Sutter EE, Tran D. The field topography of ERG components in man, I: the photopic luminance response. Vision Res 1992; 32: 433–46.
Kawabata H, Murayama K, Adachi-Usami E. Multifocal electroretinogram in myopia. Invest Ophthalmol Vis Sci. 1996; 37: 8342.
Horiguchi M, Miyake Y, Nalamura M, Fujii Y. Focal electroretinogram and visual field defect in multiple evanescent white dot syndrome. Br J Ophthalmol 1993; 77: 452–5.
Kondo M, Miyake Y, Horiguchi M, Suzuki S, Tanikawa A. Clinical evaluation of multifocal electroretinogram. Invest Ophthalmol Vis Sci 1995; 36: 2146–50.
Fletcher WA, Imes RK, Goodman D, Hoyt WF. Acute idiopathic blind spot enlargement: a big blind spot syndrome without optic disc edema. Arch Ophthalmol 1988; 106: 44–9.
Hamed LM, Glaser JS, Gass DM, Schatz NJ. Protracted enlargement of the blind spot in multiple evanescent white dot syndrome. Arch Ophthamol 1989; 107: 194–8.
Sigh K, de Frank MP, Shults WT, Watzke RC. Acute idiopathic blind spot enlargement: a spectrum of disease. Ophthalmology 1991; 98: 497–502.
Dodwell DG, Jampol LM, Rosenberg M, Berman A, Zaret CR. Optic nerve involvement associated with the multiple evanescent white-dot syndrome. Ophthalmology 1990; 97: 862–8.
Takeda N, Numata K, Yamamoto S, Katayama T, Kubota Y. Electrophysiologic findings in optic nerve dysfunction associated with multiple evanescent white-dot syndrome. Doc Ophthalmol 1992; 79: 295–302.
Murayama K, Adachi-Usami E. Visual dysfunction, in multiple evanescent white dot syndrome. Neuro-ophthalmol Jpn 1995; 12: 170–6 (in Japanese).
Shimada Y, Adachi-Usami E, Murayama K. How are macular changes reflected in pattern visually evoked potentials? Acta Ophthalmol Scand. In press.
Han DP, Thompson HS, Folk JC. Differentiation between recently resolved optic neuritis and central serous retinopathy. Arch Ophthalmol 1985; 103: 394–6.
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Huang, HJ., Yamazaki, H., Kawabata, H. et al. Multifocal electroretinogram in multiple evanescent white dot syndrome. Doc Ophthalmol 92, 301–309 (1996). https://doi.org/10.1007/BF02584084
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DOI: https://doi.org/10.1007/BF02584084