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‘Microalbuminuria’ in type I (insulin-dependent) diabetic patients with and without retinopathy

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Summary

We investigated the frequency of microalbuminuria (albumin excretion rate, AER>15 µg/min) (‘overnight’ urine collection and radioimmunological evaluation) and its relation to retinopathy (assessed by fluorangiography) in 113 type I (insulin-dependent) diabetic subjects (aged 31±13 years; diabetes duration 11±7 years), all Albustix-negative. Sixty eight patients (60.2%) were free of retinal lesions, 31 (27.4%) had background retinopathy and 14 (12.4%) had proliferative retinopathy. Microalbuminuria was found in 25 patients (22%). Fifteen patients (13%) showed both retinopathy and microalbuminuria. Fifteen % (10/68) of the patients with no retinopathy and sixteen % (5/31) of those with background retinal lesions had microalbuminuria, while 29% (4/14) of the patients with proliferative retinopathy were normoalbuminuric. Among the 29 patients with diabetes for less than five years, 1 had retinopathy and 4 had microalbuminuria. Out of 15 patients with both retinopathy and microalbuminuria, 13 (87%) had had diabetes for more than 10 years. Diabetic retinopathy is more frequent than microalbuminuria (40vs 22%). Although the linkage between retinopathy and microalbuminuria is weak, after ten years of diabetes the two complications may frequently coincide.

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Authors and Affiliations

  1. Cattedra di Malattie del Ricambio, Istituto di Clinica Medica II, Università di Pisa, Istituto di Fisiologia Clinica del CNR, Pisa

    Roberto Miccoli, Ottavio Giampietro, Giuseppe Penno, Roberto Anichini, Alessandra Bertolotto, Lorella Cruschelli, Stefania Bertoli & Renzo Navalesi

  2. Divisione di Oculistica, Spedali Riuniti di Livorno, Livorno, Italy

    Giorgio Odello

Authors
  1. Roberto Miccoli
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  2. Ottavio Giampietro
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  3. Giuseppe Penno
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  4. Giorgio Odello
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  5. Roberto Anichini
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  6. Alessandra Bertolotto
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  7. Lorella Cruschelli
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  8. Stefania Bertoli
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  9. Renzo Navalesi
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Additional information

This work was performed within the context of theRicerca Finalizzata della Regione Toscana. In addition, it was supported in part by grant no 84.02442.56 from the National Research Council and by a grant from theMinistero della Pubblica Istruzione (Ricerca Scientifica 1986).

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Miccoli, R., Giampietro, O., Penno, G. et al. ‘Microalbuminuria’ in type I (insulin-dependent) diabetic patients with and without retinopathy. Acta diabet. lat 26, 163–170 (1989). https://doi.org/10.1007/BF02581368

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  • DOI: https://doi.org/10.1007/BF02581368

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